WorksheetsPhysio Block 5 - Hema Pt. 3
Total questions: 100
Worksheet time: 50mins
Clonal selection occurs when a B lymphocyte encounters:
Chemotactic factors
Cytokines
T lymphocytes
Antigen
The titers of agglutinins in human blood usually reach their highest level at:
Immediately at birth
Infancy
Late childhood to adolescence
Middle age
Which immunoglobulin crosses the placenta to provide passive immunity to the fetus?
IgA
IgM
IgE
IgG
The basic immunoglobulin unit is composed of:
Two different heavy and two different light chains
Two identical heavy and two identical light chains
Two identical heavy and two different light chains
Two different heavy and two identical light chains
Immunologic unresponsiveness to self-antigens is known as:
Diversity
Memory
Clonal expansion
Tolerance
Presentation of antigen via MHC class I molecules results in activation of:
Helper T cells
B lymphocytes
Macrophages
Cytotoxic T cells
Cell-mediated adaptive immunity is primarily carried out by:
Neutrophils
B cells
Macrophages
T cells
Acute inflammation is characterized mainly by the influx of:
Lymphocytes
Macrophages
Plasma cells
Neutrophils
Which hypersensitivity reaction is NOT transferable by serum?
Type I
Type II
Type III
Type IV
Which immunoglobulin is most involved in anaphylaxis?
IgA
IgE
IgG
IgM
The most lethal complication of an acute transfusion reaction is:
Agglutination
Hemolysis
Sepsis
Renal failure
The coagulation pathway initiated by tissue thromboplastin is the:
Intrinsic pathway
Extrinsic pathway
Common pathway
Fibrinolytic pathway
Which test evaluates the extrinsic coagulation pathway?
Bleeding time
Clotting time
PTT
PT (INR)
Hemophilia A is caused by deficiency of:
Factor IX
Factor VII
Factor VIII
Factor XIII
Which factor stabilizes the fibrin clot?
Factor X
Thrombin
Factor XIII
Calcium
The most essential regulator of red blood cell production is:
Anemia
Vitamin B12
Erythropoietin
Tissue oxygenation
The major source of erythropoietin in adults is the:
Liver
Spleen
Bone marrow
Kidney
The most common cause of iron deficiency anemia worldwide is:
Malabsorption
Poor dietary intake
Increased hemolysis
Chronic blood loss
Which vitamin deficiency leads to megaloblastic anemia?
Vitamin K
Vitamin A
Vitamin B12
Vitamin C
Removal of the ileum most likely causes anemia due to deficiency of:
Iron
Folate
Vitamin B12
Vitamin K
Reticulocytes normally comprise what percentage of circulating RBCs?
0–0.1%
0.5–2%
5–10%
10–15%
The first identifiable cell in erythropoiesis is the:
Reticulocyte
Erythrocyte
Erythroblast
Proerythroblast
A rise in hematocrit without an increase in RBC mass is termed:
Absolute polycythemia
Secondary polycythemia
Relative polycythemia
Physiologic polycythemia
Physiologic polycythemia is most commonly seen in:
Chronic smokers
Heart failure patients
Deep sea divers
People living at high altitude
Which leukocyte is most involved in parasitic infections?
Neutrophil
Basophil
Eosinophil
Monocyte
The most abundant leukocyte in peripheral blood is the:
Lymphocyte
Monocyte
Eosinophil
Neutrophil
Which cytokine primarily activates macrophages?
IL-4
IL-5
IFN-γ
TNF-β
Delayed-type hypersensitivity reactions peak at:
1–2 hours
6–8 hours
12–18 hours
24–48 hours
The immune mechanism responsible for graft rejection is mainly:
Humoral immunity
Complement activation
Cell-mediated immunity
Innate immunity
Cyclosporine prevents graft rejection by:
Destroying lymphoid tissue
Blocking complement
Acting as IL-2 receptor antibody
Inhibiting T-helper cell activation
Which cell presents antigen to both CD4 and CD8 T cells?
Neutrophil
Eosinophil
Basophil
Dendritic cell
MHC class II molecules are expressed on:
All nucleated cells
Virally infected cells
Professional antigen-presenting cells
Platelets
Antigen processing of intravesicular antigens utilizes:
CD8 T cells
CD4 T cells
MHC class I
MHC class II
Which antibody activates complement most efficiently?
IgA
IgM
IgE
IgD
The membrane attack complex consists of:
C3b
C1q
C5a
C5b–C9
Binding of antibody and complement to microbes to enhance phagocytosis is called:
Chemotaxis
Opsonization
Diapedesis
Signal transduction
Which WBC survives for months after phagocytosis?
Neutrophil
Eosinophil
Basophil
Macrophage
The primary site of platelet destruction is the:
Liver
Bone marrow
Spleen
Kidney
Which condition prolongs bleeding time but has normal clotting time?
Hemophilia A
Vitamin K deficiency
Thrombocytopenia
DIC
The intrinsic coagulation pathway is initiated by exposure to:
Tissue factor
Collagen
Fibrin
Prothrombin
Vitamin K is required for hepatic synthesis of:
Fibrin
Fibrinogen
Globulin
Prothrombin
Body iron is stored primarily in the form of:
Hemoglobin
Cytochrome
Hemosiderin
Ferritin
Plasminogen deficiency predisposes to:
Increased bleeding
Hypocoagulation
Increased fibrinolysis
Thrombosis
The major function of red blood cells is:
Acid-base buffering
Immune defense
CO2 hydration reaction
Transport of hemoglobin
Which platelet factor causes vasoconstriction?
ADP
Thromboxane A₂
Serotonin
Fibrinogen
What prevents clotting of blood within intact vessels?
Fibrin
Serotonin
Fibrinogen
Heparin
Which antibody is most abundant in secretions such as saliva and breast milk?
IgG
IgM
IgA
IgE
Protection against intracellular microorganisms is provided by:
Antibodies
Complement
Cell-mediated immunity
Innate immunity alone
The T-helper subset responsible for eosinophil-mediated immunity is:
TH1
TH2
TH17
TH4
Which graft is almost always associated with immune rejection?
Autograft
Isograft
Allograft
Xenograft
Which immunologic mechanism is responsible for erythroblastosis fetalis?
Cytokine release from T cells
Antibody to cell surface antigens
Soluble immune complexes
IgE-mediated reaction
An Rh-negative mother is most likely to develop antibodies against Rh antigen during:
The first pregnancy with an Rh-positive fetus
The second pregnancy with an Rh-positive fetus
Any pregnancy regardless of Rh status
Only during delivery
Which Rh genotype combination can produce an Rh-negative offspring?
DD × DD
DD × Dd
Dd × Dd
DD × dd
Which immunoglobulin is primarily produced during the primary immune response?
IgG
IgA
IgE
IgM
Secondary immune responses are more effective primarily because of:
Complement activation
Mast cell degranulation
Clonal selection
Immunologic memory
Which cell type is the effector cell of humoral immunity?
Helper T cell
Cytotoxic T cell
Plasma cell
Macrophage
Which immune cell releases histamine during allergic reactions?
Eosinophil
Neutrophil
Mast cell
Macrophage
Which complement fragment is a potent chemotactic factor?
C3b
C1q
C5a
C9
Which WBC count is expected to increase most during bacterial infection?
Lymphocytes
Neutrophils
Eosinophils
Basophils
Which leukocyte count is most elevated in viral infections?
Neutrophils
Eosinophils
Lymphocytes
Basophils
The main reservoir of monocytes is the:
Blood
Bone marrow
Spleen
Lymph nodes
Diapedesis refers to the process of:
Phagocytosis
Chemotaxis
Opsonization
WBC passage through vessel walls
Which factor initiates the intrinsic coagulation pathway?
Tissue factor
Collagen exposure
Thrombin
Prothrombin
Which laboratory test primarily evaluates platelet function?
PT
PTT
Bleeding time
INR
Which coagulation factor is deficient in Hemophilia B?
Factor VIII
Factor IX
Factor XI
Factor XIII
The prothrombinase complex consists of factor Xa, calcium, and:
Factor IXa
Factor IIa
Factor Va
Factor XIIIa
Which condition results in decreased erythropoietin production?
Chronic hypoxia
High altitude
Chronic kidney disease
Polycythemia vera
Polycythemia vera is characterized by:
Increased erythropoietin levels
Secondary hypoxia
Bone marrow hyperplasia
Reduced RBC mass
Which RBC morphology is expected in iron deficiency anemia?
Macrocytic normochromic
Microcytic hypochromic
Normocytic normochromic
Macrocytic hyperchromic
Which anemia is caused by antigen–antibody reaction?
Aplastic anemia
Sickle cell anemia
Hereditary spherocytosis
Erythroblastosis fetalis
Which antibody class does not activate complement?
IgG
IgM
IgA
None of the above
Which immune response provides defense against extracellular bacteria?
Cell-mediated immunity
Humoral immunity
Innate immunity only
NK cell activity
Which cell is responsible for antibody production?
B lymphocyte
Plasma cell
Helper T cell
Macrophage
Which graft involves transplantation between genetically identical individuals?
Allograft
Xenograft
Isograft
Autograft
Which graft has the least risk of immune rejection?
Xenograft
Allograft
Isograft
Autograft
Which cytokine is most important in fever production?
IL-2
IL-4
IL-1
IFN-γ
Which immune cell is most effective at antigen presentation?
B cell
Macrophage
Dendritic cell
Neutrophil
Which immunoglobulin is predominant in colostrum?
IgG
IgM
IgA
IgE
Which antibody is produced in allergic sensitization?
IgG
IgM
IgE
IgA
Which factor converts fibrinogen to fibrin?
Factor X
Thrombin
Factor XIII
Plasmin
Which enzyme dissolves fibrin clots?
Thrombin
Plasmin
Prothrombin
Factor XIII
Tissue plasminogen activator (tPA) is selective for:
Free plasminogen
Platelet-bound plasminogen
Fibrin-bound plasminogen
Circulating thrombin
Which condition causes prolonged PTT with normal PT?
Vitamin K deficiency
Hemophilia A
Liver disease
DIC
Which factor deficiency leads to unstable clots?
Factor VIII
Factor X
Factor XIII
Factor VII
Which RBC index reflects hemoglobin concentration per cell?
MCV
MCHC
RDW
Hematocrit
Which blood group has both anti-A and anti-B antibodies?
Type A
Type B
Type AB
Type O
Which blood type is considered the universal donor for RBCs?
AB positive
O positive
O negative
AB negative
Which blood type is the universal recipient?
O negative
O positive
A positive
AB positive
Which WBC releases major basic protein?
Neutrophil
Eosinophil
Basophil
Monocyte
Which immune mechanism explains delayed hypersensitivity?
Antibody-mediated immunity
Immune complexes
T-cell mediated immunity
Complement activation
Which complement component opsonizes bacteria?
C1q
C3b
C5a
C9
Which immune cell mediates antibody-dependent cell-mediated cytotoxicity (ADCC)?
Helper T cell
Cytotoxic T cell
Natural killer cell
B lymphocyte
Which anemia is characterized by pancytopenia?
Iron deficiency anemia
Hemolytic anemia
Aplastic anemia
Megaloblastic anemia
Which RBC abnormality is seen in vitamin B12 deficiency?
Microcytosis
Hypochromia
Macrocytosis
Spherocytosis
Which hormone stimulates neutrophil production?
Erythropoietin
G-CSF
Thrombopoietin
IL-4
Which platelet-derived substance promotes aggregation?
Serotonin
ADP
Heparin
Plasmin
Which immune cell predominates in chronic inflammation?
Neutrophils
Macrophages
Basophils
Eosinophils
Which condition causes decreased plasma volume leading to relative polycythemia?
Chronic hypoxia
Bone marrow tumor
Dehydration
Erythropoietin excess
Which antibody is pentameric in structure?
IgG
IgA
IgM
IgE
Which immune process ensures survival of only useful lymphocyte clones?
Tolerance
Memory
Clonal selection
Opsonization
