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WorksheetsClinical Chemistry Quiz (Part 1)
Total questions: 50
Worksheet time: 25mins
Which team member is the coach in a Lean Six Sigma project?
Yellow Belts
Green Belts
Black Belts
Blue Belts
Calculate the Sigma value for sodium given that the total allowable error is 12%, the bias is 0.9%, and the CV is 2%.
2.16%
5.55%
21.6%
6.67%
What kind of quality control is important in maintaining long term accuracy of the analytical methods?
Intralab
Interlab
Sensitivity
Specificity
Used to calibrate pH meter:
Distilled water
Tap water
Buffer
Two of the above
AOTA
Which wavelength would be absorbed strongly by a red-colored solution?
450 nm
585 nm
600 nm
650 nm
NOTA
Used with techniques such as spectrophotometry to zero the instrument before measuring test samples and other blanks.
Reagent Blank
Sample Blank
Standard
Control
Two of the above
This is the most widely used quality control chart in the clinical laboratory.
Gaussian Curve
Cumulative Sum Graph
Youden/Twin Plot
Levey-Jennings Chart
Which of the following would not be a typical methodology for a clinical chemistry test?
Immunoturbidimetry
Microscopy
EMIT
ISE
Two of the above
How should a laboratory verify the reference range it uses for a particular test?
Call and compare with another laboratory
Use the numbers from official books
Test samples from healthy people
Look on a medical internet site
Two of the above
A value of 11.2 μg/dL thyroxine is equivalent to _________ in SI units.
135 nmol/L
135 μmol/L
145 nmol/L
145 μmol/L
The glycated hemoglobin value represents the blood glucose value during the preceding:
One to three weeks
Two to three weeks
Three to six weeks
Eight to twelve weeks
Apolipoprotein B-100 is the primary component of:
VLDL
LDL
IDL
HDL
According to the NCEP Guidelines for Acceptable Measurement Error, the coefficient of variation for HDL cholesterol should be on what range?
≤ 2%
≤ 3%
≤ 4%
≤ 5%
This is considered as a one-step method for cholesterol determination:
Liebermann – Burchardt
Abell – Kendall
Schoenheimer Sperry
Bloors
Cholesterol esterase is used in which method/s for cholesterol determination?
Chemical methods
Enzymatic methods
Both
Neither
LDL can be calculated from measurements of the following except _________ by the Friedewald formula:
Total cholesterol
VLDL
HDL
Triglyceride
Which method for the assay of uric acid is simple and nonspecific?
Colorimetric: kinetic
Colorimetric: end point
Enzymatic: UV
Enzymatic: H2O2
This condition shows a beta-gamma bridging effect as the serum protein electrophoretic pattern.
Multiple myeloma
Nephrotic syndrome
Hepatic cirrhosis
Pulmonary emphysema
In hemolytic disease of the newborn, which form of bilirubin is elevated in plasma?
Conjugated bilirubin
Unconjugated bilirubin
Delta bilirubin
B and C
Creatine kinase is under what enzyme category?
Oxidoreductases
Hydrolases
Lyases
Transferases
For each degree of fever in the patient, pO2 will fall _________& and pCO2 will rise _________%.
7, 3
3, 7
2, 5
5, 2
Confirmatory test for acromegaly:
Physical activity test
Insulin tolerance test
Somatomedin C
Glucose suppression test
In individual with hyperthyroidism will manifest _________ triglyceride levels.
Increased
Decreased
Normal
No effect
Colligative properties include all the following, EXCEPT:
Osmolality
Vapor pressure
Freezing point
Osmotic pressure
Beer’s law states that the concentration of a substance is (1) ____ proportional to the amount of light absorbed or (2) ____ proportional to the logarithm of the transmitted light:
Directly, inversely
Indirectly, direct
Both directly proportional
Both inversely proportional
The more light absorbed, the higher the concentration of analyte in this technique of measuring the amount of light absorbed by a solution:
Atomic absorption
Fluorometry
Nephelometry
Spectrophotometry
Reflectance spectrometry uses which of the following?
Luminometer
Photomultiplier tube
Tungsten-halogen lamp
UV lamp
The process by which fluorescence of an analyte is reduced due to the excited molecule losing some of its energy by interacting with other substances in solution is known as:
Ionization
Quenching
Phosphorescence
Self-absorption
In chemical reaction, the amount of product formed is measured at specific intervals during a specific period and then related to the concentration of analyte in the unknown. This type of measurement is known as:
Colometric
End-point
Rate
Ultraviolet
Indicator of nutrition, binds thyroid hormones and retinol (vitamin A) binding protein:
Orosomucoid
Cerulopasmin
Prealbumin
Hemopexin
Variants demonstrate a wide variety of cellular interactions, including roles in cell adhesion, tissue differentiation, growth, and wound healing:
Troponin
Adiponectin
Fibronectin
Cross-linked C telopeptides (CTXs)
Biochemical marker of bone resorption that can be detected in serum and urine:
Troponin
Adiponectin
Fibronectin
Cross-linked C telopeptides (CTXs)
The term describing patients who are chronically calorie malnourished and lose both adipose and muscle tissue, but who do not demonstrate a protein deficiency, is:
Marasmus
Kwashiorkor
Debilitated
None of these
Prerenal azotemia is caused by:
Acute renal failure
Chronic renal failure
Congestive heart failure
Urinary tract absorption
Azotomia due to obstruction of urine flow anywhere in the urinary tract by renal calculi, tumors of the bladder or prostate, or severe infection:
Pre-renal azotomia
Renal azotemia
Post-renal azotemia
None of these
When plasma creatinine concentration is elevated, GFR is ____, indicating renal damage:
Increased
Decreased
Normal
Variable
A complete deficiency of hypoxanthine guanine phosphoribosyltransferase results in which disease?
Lesch-Nyhan syndrome
Maple syrup urine disease
Megaloblastic anemia
Reye’s syndrome
When measuring ammonia blood levels, which of the following might cause a false increase in this analyte?
The patient had two cigarettes 15 minutes prior to blood draw
The patient was fasting for hours prior to blood collection
Immediately after phlebotomy, the blood sample was maintained on ice
The patient has steak dinner the night before the blood draw
One international unit (IU) of enzyme activity is the amount of enzyme that under specified reaction conditions of substrate concentration, pH and temperature, cause usage of substrate at the rate of:
1 millimole/min
1 nanomole/min
1 micromole/min
1 picomole/min
Catalyzes the joining of two substrate molecules, coupled with breaking of the pyrophosphate bond in adenosine triphosphate (ATP) or a similar compound:
Transferase
Hydrolase
Ligase
Lyase
In the Bowers and McComb method for determining alkaline phosphatase activity, the substrate used is:
Monophosphate
Phenylphosphate
Disodium phenylphosphate
Para-nitrophenylphosphate
It is a sensitive test for cholestasis caused by chronic alcohol or drug ingestion:
AST
ALP
ALP
GGT
A specimen is appropriate for glucose analysis if serum or plasma is separated from the cells within ____ minutes.
15 minutes
30 minutes
45 minutes
60 minutes
Dubowski method for glucose utilizes:
Phosphomolybdic acid
Arsenomolybdic acid
Ortho-toluidine
Potassium ferricyanide
C-peptide is formed during the conversion of pro-insulin to insulin. The amount of circulating C-peptide provides reliable indicators for pancreatic and insulin secretions (beta cell function). It is increased in:
Insulinoma
Ingestion of hypoglycemic drugs
Type 1 DM
Type 2 DM
Abnormal lipoprotein present in patients with biliary cirrhosis or cholestasis and in patients with mutation in lecithin: cholesterol acyltransferase (LCAT):
LDL
IDL
Lp(a)
LpX
Triglyceride levels, as chylomicrons, peak in the blood ____ hours after ingestion of a meal.
2 to 6 hours
6 to 8 hours
8 to 12 hours
12 to 14 hours
When TAG and LDL-c are being measured, fasting becomes a requirement. Require fasting of patients:
2 to 4 hours
4 to 6 hours
6 to 8 hours
12 to 14 hours
Friedewald Formula (FF) is not valid for triglycerides over ____ mg/dL
Over 100 mg/dL
Over 200 mg/dL
Over 300 mg/dL
Over 400 mg/dL
Electrolytes essential for myocardial rhythm and contractility:
Sodium, chloride, potassium
Bicarbonate, potassium, chloride
Potassium, magnesium, calcium
Calcium, magnesium
