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Clinical Chemistry Quiz (Part 1)

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

Which team member is the coach in a Lean Six Sigma project?

a)

Yellow Belts

b)

Green Belts

c)

Black Belts

d)

Blue Belts

2.

Calculate the Sigma value for sodium given that the total allowable error is 12%, the bias is 0.9%, and the CV is 2%.

a)

2.16%

b)

5.55%

c)

21.6%

d)

6.67%

3.

What kind of quality control is important in maintaining long term accuracy of the analytical methods?

a)

Intralab

b)

Interlab

c)

Sensitivity

d)

Specificity

4.

Used to calibrate pH meter:

a)

Distilled water

b)

Tap water

c)

Buffer

d)

Two of the above

e)

AOTA

5.

Which wavelength would be absorbed strongly by a red-colored solution?

a)

450 nm

b)

585 nm

c)

600 nm

d)

650 nm

e)

NOTA

6.

Used with techniques such as spectrophotometry to zero the instrument before measuring test samples and other blanks.

a)

Reagent Blank

b)

Sample Blank

c)

Standard

d)

Control

e)

Two of the above

7.

This is the most widely used quality control chart in the clinical laboratory.

a)

Gaussian Curve

b)

Cumulative Sum Graph

c)

Youden/Twin Plot

d)

Levey-Jennings Chart

8.

Which of the following would not be a typical methodology for a clinical chemistry test?

a)

Immunoturbidimetry

b)

Microscopy

c)

EMIT

d)

ISE

e)

Two of the above

9.

How should a laboratory verify the reference range it uses for a particular test?

a)

Call and compare with another laboratory

b)

Use the numbers from official books

c)

Test samples from healthy people

d)

Look on a medical internet site

e)

Two of the above

10.

A value of 11.2 μg/dL thyroxine is equivalent to _________ in SI units.

a)

135 nmol/L

b)

135 μmol/L

c)

145 nmol/L

d)

145 μmol/L

11.

The glycated hemoglobin value represents the blood glucose value during the preceding:

a)

One to three weeks

b)

Two to three weeks

c)

Three to six weeks

d)

Eight to twelve weeks

12.

Apolipoprotein B-100 is the primary component of:

a)

VLDL

b)

LDL

c)

IDL

d)

HDL

13.

According to the NCEP Guidelines for Acceptable Measurement Error, the coefficient of variation for HDL cholesterol should be on what range?

a)

≤ 2%

b)

≤ 3%

c)

≤ 4%

d)

≤ 5%

14.

This is considered as a one-step method for cholesterol determination:

a)

Liebermann – Burchardt

b)

Abell – Kendall

c)

Schoenheimer Sperry

d)

Bloors

15.

Cholesterol esterase is used in which method/s for cholesterol determination?

a)

Chemical methods

b)

Enzymatic methods

c)

Both

d)

Neither

16.

LDL can be calculated from measurements of the following except _________ by the Friedewald formula:

a)

Total cholesterol

b)

VLDL

c)

HDL

d)

Triglyceride

17.

Which method for the assay of uric acid is simple and nonspecific?

a)

Colorimetric: kinetic

b)

Colorimetric: end point

c)

Enzymatic: UV

d)

Enzymatic: H2O2

18.

This condition shows a beta-gamma bridging effect as the serum protein electrophoretic pattern.

a)

Multiple myeloma

b)

Nephrotic syndrome

c)

Hepatic cirrhosis

d)

Pulmonary emphysema

19.

In hemolytic disease of the newborn, which form of bilirubin is elevated in plasma?

a)

Conjugated bilirubin

b)

Unconjugated bilirubin

c)

Delta bilirubin

d)

B and C

20.

Creatine kinase is under what enzyme category?

a)

Oxidoreductases

b)

Hydrolases

c)

Lyases

d)

Transferases

21.

For each degree of fever in the patient, pO2 will fall _________& and pCO2 will rise _________%.

a)

7, 3

b)

3, 7

c)

2, 5

d)

5, 2

22.

Confirmatory test for acromegaly:

a)

Physical activity test

b)

Insulin tolerance test

c)

Somatomedin C

d)

Glucose suppression test

23.

In individual with hyperthyroidism will manifest _________ triglyceride levels.

a)

Increased

b)

Decreased

c)

Normal

d)

No effect

24.

Colligative properties include all the following, EXCEPT:

a)

Osmolality

b)

Vapor pressure

c)

Freezing point

d)

Osmotic pressure

25.

Beer’s law states that the concentration of a substance is (1) ____ proportional to the amount of light absorbed or (2) ____ proportional to the logarithm of the transmitted light:

a)

Directly, inversely

b)

Indirectly, direct

c)

Both directly proportional

d)

Both inversely proportional

26.

The more light absorbed, the higher the concentration of analyte in this technique of measuring the amount of light absorbed by a solution:

a)

Atomic absorption

b)

Fluorometry

c)

Nephelometry

d)

Spectrophotometry

27.

Reflectance spectrometry uses which of the following?

a)

Luminometer

b)

Photomultiplier tube

c)

Tungsten-halogen lamp

d)

UV lamp

28.

The process by which fluorescence of an analyte is reduced due to the excited molecule losing some of its energy by interacting with other substances in solution is known as:

a)

Ionization

b)

Quenching

c)

Phosphorescence

d)

Self-absorption

29.

In chemical reaction, the amount of product formed is measured at specific intervals during a specific period and then related to the concentration of analyte in the unknown. This type of measurement is known as:

a)

Colometric

b)

End-point

c)

Rate

d)

Ultraviolet

30.

Indicator of nutrition, binds thyroid hormones and retinol (vitamin A) binding protein:

a)

Orosomucoid

b)

Cerulopasmin

c)

Prealbumin

d)

Hemopexin

31.

Variants demonstrate a wide variety of cellular interactions, including roles in cell adhesion, tissue differentiation, growth, and wound healing:

a)

Troponin

b)

Adiponectin

c)

Fibronectin

d)

Cross-linked C telopeptides (CTXs)

32.

Biochemical marker of bone resorption that can be detected in serum and urine:

a)

Troponin

b)

Adiponectin

c)

Fibronectin

d)

Cross-linked C telopeptides (CTXs)

33.

The term describing patients who are chronically calorie malnourished and lose both adipose and muscle tissue, but who do not demonstrate a protein deficiency, is:

a)

Marasmus

b)

Kwashiorkor

c)

Debilitated

d)

None of these

34.

Prerenal azotemia is caused by:

a)

Acute renal failure

b)

Chronic renal failure

c)

Congestive heart failure

d)

Urinary tract absorption

35.

Azotomia due to obstruction of urine flow anywhere in the urinary tract by renal calculi, tumors of the bladder or prostate, or severe infection:

a)

Pre-renal azotomia

b)

Renal azotemia

c)

Post-renal azotemia

d)

None of these

36.

When plasma creatinine concentration is elevated, GFR is ____, indicating renal damage:

a)

Increased

b)

Decreased

c)

Normal

d)

Variable

37.

A complete deficiency of hypoxanthine guanine phosphoribosyltransferase results in which disease?

a)

Lesch-Nyhan syndrome

b)

Maple syrup urine disease

c)

Megaloblastic anemia

d)

Reye’s syndrome

38.

When measuring ammonia blood levels, which of the following might cause a false increase in this analyte?

a)

The patient had two cigarettes 15 minutes prior to blood draw

b)

The patient was fasting for hours prior to blood collection

c)

Immediately after phlebotomy, the blood sample was maintained on ice

d)

The patient has steak dinner the night before the blood draw

39.

One international unit (IU) of enzyme activity is the amount of enzyme that under specified reaction conditions of substrate concentration, pH and temperature, cause usage of substrate at the rate of:

a)

1 millimole/min

b)

1 nanomole/min

c)

1 micromole/min

d)

1 picomole/min

40.

Catalyzes the joining of two substrate molecules, coupled with breaking of the pyrophosphate bond in adenosine triphosphate (ATP) or a similar compound:

a)

Transferase

b)

Hydrolase

c)

Ligase

d)

Lyase

41.

In the Bowers and McComb method for determining alkaline phosphatase activity, the substrate used is:

a)

Monophosphate

b)

Phenylphosphate

c)

Disodium phenylphosphate

d)

Para-nitrophenylphosphate

42.

It is a sensitive test for cholestasis caused by chronic alcohol or drug ingestion:

a)

AST

b)

ALP

c)

ALP

d)

GGT

43.

A specimen is appropriate for glucose analysis if serum or plasma is separated from the cells within ____ minutes.

a)

15 minutes

b)

30 minutes

c)

45 minutes

d)

60 minutes

44.

Dubowski method for glucose utilizes:

a)

Phosphomolybdic acid

b)

Arsenomolybdic acid

c)

Ortho-toluidine

d)

Potassium ferricyanide

45.

C-peptide is formed during the conversion of pro-insulin to insulin. The amount of circulating C-peptide provides reliable indicators for pancreatic and insulin secretions (beta cell function). It is increased in:

a)

Insulinoma

b)

Ingestion of hypoglycemic drugs

c)

Type 1 DM

d)

Type 2 DM

46.

Abnormal lipoprotein present in patients with biliary cirrhosis or cholestasis and in patients with mutation in lecithin: cholesterol acyltransferase (LCAT):

a)

LDL

b)

IDL

c)

Lp(a)

d)

LpX

47.

Triglyceride levels, as chylomicrons, peak in the blood ____ hours after ingestion of a meal.

a)

2 to 6 hours

b)

6 to 8 hours

c)

8 to 12 hours

d)

12 to 14 hours

48.

When TAG and LDL-c are being measured, fasting becomes a requirement. Require fasting of patients:

a)

2 to 4 hours

b)

4 to 6 hours

c)

6 to 8 hours

d)

12 to 14 hours

49.

Friedewald Formula (FF) is not valid for triglycerides over ____ mg/dL

a)

Over 100 mg/dL

b)

Over 200 mg/dL

c)

Over 300 mg/dL

d)

Over 400 mg/dL

50.

Electrolytes essential for myocardial rhythm and contractility:

a)

Sodium, chloride, potassium

b)

Bicarbonate, potassium, chloride

c)

Potassium, magnesium, calcium

d)

Calcium, magnesium