
Pharmacotherapy Hypertension
Presentation
•
Science, Education, Specialty
•
University
•
Medium
Faith Anne
Used 9+ times
FREE Resource
31 Slides • 94 Questions
1
Pharmacotherapy Hypertension
2
Multiple Choice
Cardiac Output is
Stroke Volume x Blood Pressure
Stroke Volume x Heart Rate
Heart Rate x Blood Pressure
Heart Rate x Afterload
3
Multiple Choice
Blood Pressure is
Cardiac Output x Peripheral Resistance
Heart Rate x Peripheral Resisitance
Cardiac Output x Heart Rate
Stroke Volume x Cardiac Output
4
Multiple Choice
what percent of patients have their Blood Pressure under control?
50%
57%
47%
52%
5
Multiple Choice
What percentage of Americans have Hypertention?
57%
47%
50%
40%
6
Fill in the Blank
What is the most common condition in primary care?
7
•HTN is the most common condition in primary care
–1 in 3 American adults have prehypertension
–46% of American adults have HTN
•Prevalence in patients 20 – 44 years old: 30% men and 19% women
•Prevalence in patients 65 – 74 years old: 77% men and 75% women
•Only about half (52%) of patients with HTN have it under control
•69% of people who have a first MI, 77% of people with a first CVA, and 74% of people with HF have HTN
Major risk factor for MI, CVA, ARF, and death
8
Multiple Choice
Hypertension is a major risk factor for
Diabetes
Cardiovascular Disease
Obesity
Depression
9
Multiple Choice
The risk of CVD begins at
120/80
130/80
115/75
140/90
10
Fill in the Blank
With each increment increase of 20 mmHg SBP or 10 mmHg DBP was associated with a _______ in the risk of death from stroke, heart disease or other vascular disease
11
Multiple Choice
In persons > 50 years, ____ is a much more important CVD risk factor than ____
SBP, DBP
DBP, SBP
12
Multiple Choice
What ethnicity develops HTN more often, and at an earlier age than other ethnicities
Hispanics
Asians
Blacks
Native Americans
13
Multiple Select
CVD major risk factors include
Obesity
Tobacco Use
Dyslipiemia
DM
microalbuminuria or eGFR < 60 mL/min
14
Multiple Choice
What ages for women and men become a major risk factor for CVD?
55;65
50;60
65;55
60;50
15
Multiple Select
What are modifiable risk factors for CVD?
Diabetes mellitus
Overweight/Obesity
Socioeconomic status
Diet
Obstructive sleep apnea
16
Multiple Select
What are non-modifiable risk factors for CVD?
Age
Overweight/Obesity
Socioeconomic status
Diet
Obstructive sleep apnea
17
Multiple Choice
T/F: With increased patient age vasculature hardening is more common
True
False
18
CVD major risk factors
HTN, cigarette smoking, obesity (BMI ≥ 30 kg/m2), physical inactivity, dyslipidemia, DM, microalbuminuria or eGFR < 60 mL/min, age (> 55 men, > 65 women), family history of premature CVD (men < 55, women < 65)
19
CVD major risk factors
HTN, cigarette smoking, obesity (BMI ≥ 30 kg/m2), physical inactivity, dyslipidemia, DM, microalbuminuria or eGFR < 60 mL/min, age (> 55 men, > 65 women), family history of premature CVD (men < 55, women < 65)
20
Multiple Select
What complications can be associated with HTN?
Heart
Brain
PAD
CKD
Retinopathy
21
Multiple Select
When counseling a patient on HTN it can be good to mention that reducing blood pressure can also reduce which of the following
Stroke incidence by 35-40%
Myocardial Infarction (heart attack) by 45-50%
Heat failure by 50%
Obesity
22
Complications of HTN
Heart
–Left ventricular hypertrophy
–Heart failure
–Angina or myocardial infarction (MI)
–Prior coronary revascularization
Brain
–CVA or TIA
Chronic Kidney Disease (CKD)
Peripheral Arterial Disease (PAD)
Retinopathy
23
24
Multiple Choice
A patient with a blood pressure reading of 118/85 is classified as
Normal
Elevated BP
Stage 1 HTN
Stage 2 HTN
25
Multiple Choice
When evalauating BP which number dictates the BP category?
Systolic
Diastolic
Lower
Higher
26
Multiple Choice
A patients BP is 139/86 what is their BP classification?
Normal
Elevated
Stage 1 HTN
Stage 2 HTN
27
28
Multiple Choice
What is the Mean Arterial Pressure (MAP) of a patient with a BP measuring 118/78?
61 mmHg
93 mmHg
91 mmHg
65 mmHg
29
Multiple Choice
What is Mean Arterial Pressure an indicator of?
Stroke Volume
Renal Flow
Vital Organ Perfusion
Heart Attack
30
MAP is an indicator of organ perfusion and will be important when monitoring critical care patients
31
Multiple Choice
T/F: Should a patient be told their blood pressure after the reading is taken?
True
False
32
Multiple Choice
When taking a BP reading what rate should the cuff be deflated when finding the DBP?
1 mmHg/sec
2 mmHg/sec
3 mmHg/sec
4 mmHg/sec
33
Multiple Choice
If a patient with previosly normal BP presents to the clinic and 2 BP readings are taken both are high. Is it appropriate for them to be diagnosed with HTN at this visit?
Yes
No
34
Home and Ambulatory BP Monitoring
Out-of-office BP measurements are recommended to confirm HTN dx and titration of BP-lowering medication
–Should be used with telehealth counseling or clinical interventions
35
Fill in the Blank
____ HTN is higher office BPs than out-of-office BPs
36
Fill in the Blank
____ HTN is controlled office BPs but uncontrolled out-of-office settings
37
Multiple Choice
When is White Coat HTN clinically significant?
SBP/DBPs are > 10/10 mmHg higher than HBPM or ABPM
SBP/DBPs are > 20/20 mmHg higher than HBPM or ABPM
SBP/DBPs are > 20/10 mmHg higher than HBPM or ABPM
SBP/DBPs are > 15/10 mmHg higher than HBPM or ABPM
38
Multiple Choice
A patient recieving HTN treatment presents with unrecognized White Coat HTN could be misdiagnosed with
Controlled HTN
Stage 2 HTN
Masked HTN
Resistant HTN
39
Fill in the Blank
Masked HTN is associated with ____ prevalence of target organ damage and risk of CVD, stroke, and mortality compared with normotensive individuals and those with white coat hypertension
40
White Coat, Masked, & Sustained HTN
White Coat HTN: higher office BPs than out-of-office BPs
-Clinically significant when office SBP/DBPs are > 20/10 mmHg higher than HBPM or ABPM
-Implicated in “pseudo-resistant HTN”
-Results in underestimation of office BP control rates
-Prevalence: higher in w/increasing age, females, nonsmokers and routine office BP measurement by clinician observers vs unattended BP measurements
Masked HTN: controlled office BPs but uncontrolled out-of-office settings
-Associated with increased prevalence of target organ damage and risk of CVD, stroke, and mortality compared with normotensive individuals and those with white coat hypertension
41
Multiple Choice
A patient presents with an office BP of 145/82, they say they have been following the DASH diet and getting ~90 min exercise every week. The HBP log they brought in shows and average BP of 122/80. What type of BP does this patient have and when should they be followed up with?
Masked HTN; 12 months
White Coat HTN; 12 months
Elevated BP; 1 month
Stage 1 HTN; 1 month
42
Multiple Choice
A patient presents with an office BP of 118/79, they say they have been following the DASH diet and getting ~90 min exercise every week. The HBP log they brought in shows and average BP of 133/80. What type of BP does this patient have and when should they be followed up with?
Masked HTN; 1 months
White Coat HTN; 12 months
Elevated BP; 1 month
Stage 1 HTN; 1 month
43
44
Multiple Select
What factors would require an intisification of HTN therapy in a patient with detected masked HTN and currently on HTN therapy?
Office BP is at goal
HBPM and ABPM are above goal
Patient shows no increased CVD risk or target organ damage
Office BP is > 5-10 mmHg while on HTN therapy
45
46
Multiple Select
95% of patients have primary HTN, what are identified casues of primary HTN?
Genetic
Environmental
Unknown
Drugs
47
Multiple Select
Examples of environmentalcauses of primary HTN are
Sodium intake
Obesity
Alcohol abuse
Sedentary lifestyle
48
Primary or “Essential” HTN
–95% of patients have primary HTN
Cause unknown in most cases
- Genetic
High RAAS activity, SNS activity
- Environmental
Excess sodium intake, obesity sedentary lifestyle
49
Multiple Select
When screening for secondary HTN what would need to be or not be seen to refer a pateint to a clinician with expertise in this specialty?
Disproportioante TOD for degree of HTN
Positive screen for secondary HTN
Unprovoked or excessive hyperkalemia
Onset of HTN in pts < 30 y
Drug resistant/induced HTN
50
Multiple Select
TOD indicates target organ damage. What are examples of damage?
Cerebrovascular disease
Left ventricular hypertrophy
Rightventricular dysfunction
Heart failure
Albuminuria
51
TOD indicates target organ damage
cerebrovascular disease, hypertensive retinopathy, left ventricular hypertrophy, left ventricular dysfunction, heart failure, coronary artery disease, chronic kidney disease, albuminuria, peripheral artery disease
52
Multiple Select
Examples of medications & other substances that may cause elevated BP
Alcohol
Antidepressants
Decongestants
Immunosuppresants
•Systemic corticosteroids
53
Medications & Other Substances that May Cause Elevated BP
•Alcohol
•Amphetamines
•Antidepressants
•Atypical antipsychotics
•Caffeine
•Decongestants
•Herbal supplements
•Immunosuppresants
•Oral contraceptives
•NSAIDs
•Recreational drug use
•Systemic corticosteroids
•Angiogenesis inhibitors
54
Multiple Select
Three objectives in the evaluation of patients with documented HTN include
To assess lifestyle and identify other CV risk factors
To titrate HTN medications according to current lab values
To reveal identifiable causes of high BP
To assess the presence or absence of target organ damage and CVD
55
•Evaluation of patients with documented HTN has 3 objectives
To assess lifestyle and identify other CV risk factors or concomitant disorders that may affect prognosis and guide treatment
To reveal identifiable causes of high BP
To assess the presence or absence of target organ damage and CVD
•Target organ damage: microvascular and macrovascular injuries
56
Multiple Select
A thorough medical evaluation includes
Medical history
Physical examination
Routine laboratory tests
Optional diagnostic procedures
57
Multiple Select
Routine laboratory tests in the medical evaluation for a patient with documented HTN include
BMP
FBG
CBC w/differentials
Urinalysis
eGFR
58
Patient Evaluation
A thorough medical evaluation includes
–Medical history
–Physical examination
–Routine laboratory tests
•BMP, FBG, CBC w/differentials, FLP, eGFR, TSH, Urinalysis, Serum Na, K, Ca2+
Optional diagnostic procedures
•Echocardiogram, Uric acid, UA:creatinine ratio
59
Multiple Select
BP lowering medications should be used in the primary prevention of CVD in adults with ____ history of CVD with an estimated 10-year ASCVD risk ____ 10% and an SBP ≥140 mmHg or DBP ≥90 mmHg
no
recurrent
<
>
60
Multiple Select
Secondary Prevention of ____ CVD events in patients with clinical CVD and an average SBP ≥___ mmHg or an average DBP ≥ 80 mmHg
no
recurrent
130
140
61
BP Treatment Threshold & the Use of CVD Risk Estimation to Guide Treatment of HTN
BP-lowering medications should be used in:
–Primary Prevention of CVD in adults with no history of CVD with an estimated 10-year ASCVD risk <10% and an SBP ≥140 mmHg or DBP ≥90 mmHg
Secondary Prevention of recurrent CVD events in patients with clinical CVD and an average SBP ≥130 mmHg or an average DBP ≥ 80 mmHg
62
Multiple Select
What patient information is needed to fill in the ASCVD Risk calulator?
Age
Sex (at birth)
Race
BP
On HTN treatment
63
64
Multiple Select
Under what conditions should a patient have their BP checked yearly?
Normal BP
Healthy life style promoted
Elevated BP
Stage 1 HTN
Stage 2 HTN
65
Multiple Select
When should a patient with elevated BP and is practicing nonpharmacologocal therapies be re-evaluated?
1-2 months
3-6 months
8-9 months
12 months
66
Multiple Choice
When should a patient with Stage 1 HTN and an ASCVD risk greater than 10% and begins recieving pharmacological and nonpharmacological treatment have their BP re-evaluated?
1 month
3 months
6 months
12 months
67
Multiple Choice
A patient with Stage 2 HTN who is on nonpharmacological and 2 pharmacological treatments for HTN and is meeting their BP goal should be reassed in how many months?
1-2 months
3-6 months
7-8 months
12 months
68
69
Multiple Select
Most clinical conditions have a BP threshold of 130(SBP) or 130/80 and a goal of 130/80. What conditions is threshold 140/90?
Older persons
No clinical CVD or ASCVD risk <10%
Clinical CVD or >10% ASCVD risk
Stable Ischemic heart disease
Stroke
70
BP Thresholds & Goals of Pharmacological Therapy
71
Multiple Select
What are the primary oral antihypertensive medication classes
Thiazides
ACEIs
ARBs
CCBs
Beta Blockers
72
Multiple Select
Secondary agents used in the oral treatment of HTN include
Loop and K+ sparing diuretics
Aldosterone antagonists
Beta blockers
Alpha-1 blockers
Direct vasodialators
73
Oral Antihypertensive Drugs
Primary Agents
•Thiazide/thiazide-like diuretics
•ACEIs
•ARBs
•CCBs
Secondary Agents
•Loop diuretics
•K+ sparing diuretics
•Aldosterone antagonists
•Beta-blockers
•Direct-Renin Inhibitors
•Alpha-1 blockers
•Central alpha-2 agonists
•Direct vasodilators
74
Multiple Select
Which of the below medications are available in liquid form?
Amlodipine
Hydrochlorothizide
Enalapril
Valsartan
Lisinoprl
75
Multiple Choice
Which α2-adrenergic agonist is avaialbel as a patch?
Guanfacine
Tizanidine
Clonidine
Dexmedetomidine
76
Multiple Choice
Stage 1 HTN patients with a BP goal of 130/80 mmHg should initially recieve what type of therapy in addition to nonpharmacological therapy
Monotherapy
Combination therapy
No therapy
77
Multiple Choice
What Stage of Hypertension will a patient initially recieve combination therapy along with nonpharmacological therapy?
Normal
Elevated
Stage 1
Stage 2
78
Choice of Medication
First-line Agents
–Thiazide-diuretics, ACEIs, ARBs, CCBs
Initial Monotherapy
–Stage I HTN: start with a single antihypertensive drug is reasonable
–Dosage titration and sequential addition of other agents to achieve the BP target
–BP goal <130/80 mm Hg
Initial Combination Therapy
–Stage 2 HTN (w/avg BP > 20/10 mmHg above BP target): start with 2 first-line agents of different classes, either as separate agents or in a fixed-dose combination
79
Follow-Up & Monitoring
Adults initiating a new or adjusted drug regimen for hypertension should have a follow-up evaluation of adherence and response to treatment every month until control is achieved
Follow-up and monitoring after initiation of drug therapy for hypertension control should include systematic strategies to help improve BP, including use of HBPM, team-based care, and telehealth strategies.
80
Multiple Select
The preferred antihypertensive agents in patients with systolic heart failure include
ACEIs
ARBs
Aldosterone antagonist
Diuretics
Beta blockers
81
Multiple Select
The preferred antihypertensive agents in patients post MI include
ACEIs
ARBs
Aldosterone antagonist
Diuretics
Beta blockers
82
Multiple Select
The preferred antihypertensive agents in patients with CKD nclude
ACEIs
ARBs
CCBs
Diuretics
Beta blockers
83
Multiple Select
The preferred antihypertensive agents in patients with Diabetes include
ACEIs
ARBs
CCBs
Thiazides
Beta blockers
84
Multiple Select
The preferred antihypertensive agents in patients with angina pectoris include
ACEIs
ARBs
CCBs
Thiazides
Beta blockers
85
Multiple Select
The preferred antihypertensive agents in patients that are pregnant include
Lisinopril
Losartan
Nifedipine CC
Methyldopa
Labetalol
86
•Preferred Medication for Certain Populations
87
Multiple Select
Beta blockers have a favorable effect on what conditions other than HTN?
Hyperthyroidism
Migraine
Osteoporosis
Perioperative HTN
BPH
88
Multiple Choice
Alpha blockers have a favorable effect on what conditions other than HTN?
Hyperthyroidism
Migraine
Osteoporosis
Perioperative HTN
BPH
89
Multiple Choice
Thiazide diuretics have a favorable effect on what conditions other than HTN?
Hyperthyroidism
Migraine
Osteoporosis
Perioperative HTN
BPH
90
Multiple Choice
Noncardioselective beta blockers have a favorable effect on what conditions other than HTN?
Hyperthyroidism
Migraine
Osteoporosis
Perioperative HTN
Essential tremor
91
Multiple Select
What HTN meidcations are contraindicated in Angioedema
ACEIs
ARBs
CCBs
Aliskerin
Beta blockers
92
Multiple Select
What HTN meidcations are contraindicated in Preganacy
ACEIs
ARBs
CCBs
Aliskerin
Beta blockers
93
Multiple Select
What HTN meidcations are contraindicated in Hyperkalemia
ACEIs
ARBs
CCBs
Aliskerin
Aldosterone antagonists
94
Multiple Select
What HTN meidcations are contraindicated in Bilateral renal stenosis
ACEIs
ARBs
CCBs
Aliskerin
Aldosterone antagonists
95
Multiple Select
What HTN meidcations are contraindicated in Acute renal failure
ACEIs
ARBs
Thiazide diuretics
Aliskerin
Aldosterone antagonists
96
97
Open Ended
Your preceptor asks you to speak with a patient about suppliments for HTN. What advice do you have for the patient about the use of suppliments?
98
Multiple Choice
When treating patients with stable ischemic heart disease whose BP goal of <130/80 is not met with GDMT and is experiencing angina pectoris should also recieve what type of medications?
nonDHPCCB
DHPCCB
ARB
Thiazide
99
100
Multiple Choice
Patients with HTN and CKD that cannot tolerate ACEIs should recieve an ARB. However, pateints post renal transplantation should recieve what type of medications?
Beta blockers
Alpha blocker
CCB
Thiazide
101
Multiple Select
Drugs of choice for adult patients with previously treated HTN + stroke/transient ischemic attack (TIA) are
ACEIs
ARBs
CCBs
Thiazides
Combination
102
Multiple Select
Adults NOT previously treated for HTN + stroke/TIA and have an established BP ≥140/90 mm Hg should have thier medication administration selection based on what?
HTN meds should be initiated immediatly
HTN meds should be started a few days after the event
Should be based on the treatments used for patients who have previously recieved HTN treatment
Should be based on the patients comorbidities
103
Multiple Choice
Hypertension management in patients with PAD should be treated
with Beta blockers
with CCBs
similarly to patients without PAD
with aldosterone antagonists
104
Multiple Select
Hypertension management in patients with DM can be treated with
ACEIs
ARBs
Thiazides
CCBs
105
Multiple Choice
Hypertension management in patients with AFIB can be treated with
ACEIs
ARBs
Thiazides
CCBs
106
Multiple Choice
Which beta blocker should not be used in the treatment of HTN in patients with stable ischemic heart disease?
Metoprolol
Timolol
Atenolol
Carvedilol
Propranolol
107
Multiple Choice
Older Persons ≥ 65 years of age SBP treatment goal <___ recommended for noninstitutionalized ambulatory community-dwelling adults
120
130
140
108
Special Patient Groups
Race & Ethnicity
–Black adults without HF or CKD: initial treatment should include thiazide diuretic or CCB
–2 or more medications are recommended to achieve goal BP in most adults and especially black adults w/HTN
Older Persons (≥ 65 years of age)
–SBP treatment goal <130 recommended for noninstitutionalized ambulatory community-dwelling adults
–Patients with high-burden of comorbidity & limited life expectancy, clinical judgement, patient preference, & a team-based approach assess risk/benefit regarding intensity of BP lowering & choice of drugs
109
Multiple Select
Women who are planning or become pregnant should be transitioned to what medications for HTN management
Lisinopril
Valsartan
Nifedipine CC
Labetalol
Methyldopa
110
Treatment during pregnancy
–Women who are planning or become pregnant should be transitioned to methyldopa, nifedipine, and/or labetalol during pregnancy; use the lowest effective dose possible
–Do not treat with ACEIs, ARBs, or direct renin inhibitors
–Use drugs that have been used the longest periods of time with safety
•Gestational Hypertension (chronic): > 140/90 prior to pregnancy or before 20 weeks gestation. Persists > 12 weeks postpartum
–Treat if SBP > 160 or DBP >105
•BP target 120 – 160 SBP and 80 – 105 DBP
–Drugs of choice: methyldopa, labetalol, nifedipine ER
•Preeclampsia: > 140/90 with proteinuria
–Must be treated and monitored for progression carefully
111
Multiple Select
How is a patient evaluated for resistant HTN ?
Confirm treatment resistance
Exclude pseudoresistance
Assess for secondary HTN
Assess for target organ damage
112
Multiple Choice
The management of resistant HTN entails how many steps?
4
5
6
7
113
Multiple Select
Step one in the management of resistant HTN includes
Excluding other causes of HTN
Ensure low sodium diet and appropriate lifestyle modifications
Substitute optimally dosed thiazide-like diuretics
Add MRA
Optimize a three drug regimine
114
Multiple Choice
Step two in the management of resistant HTN includes
Excluding other causes of HTN
Ensure low sodium diet and appropriate lifestyle modifications
Substitute optimally dosed thiazide-like diuretics
Add MRA
Optimize a three drug regimine
115
Multiple Choice
Step three in the management of resistant HTN includes
Excluding other causes of HTN
Ensure low sodium diet and appropriate lifestyle modifications
Substitute optimally dosed thiazide-like diuretics
Add MRA
Optimize a three drug regimine
116
Multiple Choice
Step four in the management of resistant HTN includes
Check heart rate and add a beta blocker
Ensure low sodium diet and appropriate lifestyle modifications
Substitute optimally dosed thiazide-like diuretics
Add MRA
Optimize a three drug regimine
117
Multiple Choice
Step five in the management of resistant HTN includes
Check heart rate and add a beta blocker
Ensure low sodium diet and appropriate lifestyle modifications
Substitute optimally dosed thiazide-like diuretics
Add hydralazine
Optimize a three drug regimine
118
Multiple Choice
Step six in the management of resistant HTN includes
Check heart rate and add a beta blocker
Ensure low sodium diet and appropriate lifestyle modifications
Substitute optimally dosed thiazide-like diuretics
Add hydralazine
Substiture minoxidil for hydralazine
119
Multiple Choice
T/F: A hypertensive crisis requires admission to the ICU
True
False
120
Multiple Select
In the management of a hypertensive crisis how much should BP be lowered in the 1st hour?
Reduce SBP to <140 mmHg in pre-eclampsia and pheochromocytoma
Reduce to <120 mmHg in aortic disection
Reduce to <120 mmHg if pateint has not experienced aortic dissection, pre-eclampsia or pheochromocytoma
Reduce by 25% mmHg if pateint has not experienced aortic dissection, pre-eclampsia or pheochromocytoma
121
Hypertensive Crises:
Emergencies & Urgencies
Hypertensive emergency
–Admission to an ICU is recommended for continuous monitoring of BP and target organ damage and for parenteral administration of an appropriate agent
–
–Compelling condition (i.e., aortic dissection, severe preeclampsia or eclampsia, or pheochromocytoma crisis), SBP should be reduced to < 140 mm Hg during the first hour and to < 120 mm Hg in aortic dissection
–
–Without a compelling condition, SBP should be reduced by no more than 25% within the first hour; then, if stable, to 160/100 mm Hg within the next 2 to 6 hours; and then cautiously to normal during the following 24 to 48 hours
122
Multiple Select
What are the strategies used to improve HTN treatment and control
Medication Adherence
Lifestyle Modification
Provider Silo based care
EHR & Patient Registries
Telehealth strategies
123
Strategies to Improve HTN Treatment and Control
•Medication Adherence
–Dose antihypertensive meds once vs multiple times daily
–Use combination pills rather than free individual components
•Lifestyle Modification
–Effective behavioral and motivational strategies to achieve a healthy lifestyle
•Team-based Care
–Recommended approach for treatment
•EHR & Patient Registries
–Useful to identify patients with undiagnosed/undertreated HTN
•Telehealth strategies
124
Multiple Select
A plan of care for HTN should include a clear, detailed, and current evidence-based plan of care that ensures
The achievement of treatment & self-management goals
Encourages effective management of comorbid conditions
Prompts timely follow-up with the healthcare team
Adheres to CVD GDMT
125
Open Ended
A patient was notified that the Valsartan they have been taking was recalled for causing cancer. They are now calling and asking what they should do. Your preceptor wants you to speak with the patient. What do you tell the pateint?
Pharmacotherapy Hypertension
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