Pharmacokinetics - Part 4

Review!

9-13

Multiple Choice

What does the onset of drug action begin with?

• When drug reaches peak plasma level

• When drug enters plasma and achieves MEC

• When drug is eliminated from plasma

• When drug binds to receptor

Multiple Choice

Which route of administration achieves peak plasma level immediately?

• Oral

• Subcutaneous

• Intravenous

• Intramuscular

Drag and Drop

The time elapsed between drug administration and peak plasma level is called​

Placeholder

to ​

Placeholder

Drag these tiles and drop them in the correct blank above

time

peak

duration

minimum

maximum

Multiple Choice

Which statement about loading dose is TRUE?

• It is given to rapidly achieve therapeutic plasma levels

• It is given to maintain plasma levels over time

• It is always a single dose

• It prevents drug elimination

Review!

1 slide

Multiple Choice

What is the minimum plasma concentration required for a pharmacological response called?

• MTC

• MEC

• Loading dose

• Peak level

Review!

23 - 25

Drag and Drop

The dissociation constant is used to measure a drug’s ​

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for its receptor.

Drag these tiles and drop them in the correct blank above

affinity

potency

efficacy

Multiple Choice

What does affinity measure?

• The speed of drug absorption

• The rate of drug elimination

• The plasma concentration of the drug

• The strength of drug binding to its receptor

Final Review!

Multiple Choice

Which drug action does NOT involve receptor binding?

• Agonist activity

• Osmotic effect of mannitol

• Competitive antagonism

• Partial agonism

Multiple Choice

Which type of antagonist competes for the same receptor site as the agonist?

• Noncompetitive antagonist

• Partial antagonist

• Competitive antagonist

• Weak antagonist

Drag and Drop

A drug that binds to a receptor and produces maximal cellular effect is called a ​

Placeholder

agonist.

Drag these tiles and drop them in the correct blank above

full

partial

antagonist

inverse

Match

Match the term with its definition:

• Drug that binds and stimulates a receptor response

• Plasma level at which toxic effects occur

• Drug that binds and prevents receptor function

• Minimum plasma concentration for therapeutic effect

Agonist

MTC

Antagonist

MEC

• Agonist

• MTC

• Antagonist

• MEC

Categorize

Options (4)

Full agonist

Noncompetitive antagonist

Mannitol

Partial agonist

Categorize the following as Agonist, Antagonist, or Other Mechanism:

Agonist

Antagonist

Other

Multiple Choice

What does agonist mean?

• A drug that activates a receptor.

• A molecule that blocks receptor activity.
• A drug that binds without effect.

• A drug that inhibits a receptor.

Multiple Choice

What does antagonist mean when it comes to drugs?

• A drug that blocks or inhibits the action of a receptor.
• A drug that mimics the action of a receptor.
• A drug that has no effect on receptors.
• A drug that enhances the action of a receptor.