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WorksheetsHEMA311 WEEK 3
Total questions: 70
Worksheet time: 25mins
Hematopoiesis is a continuous, regulated process of blood cell production. It includes replenishment, multiplication of cells, and differentiation from immature to mature cells.
1st statement is correct, 2nd statement is wrong
1st statement is wrong, 2nd statement is correct
Both statements are correct
Both statements are wrong
These stem cells are present several days after fertilization.
Totipotential stem cells
Pluripotential stem cells
Multipotential stem cells
Hematopoietic stem cells
(a) involves the formation, development, and specialization of blood cells in the bone marrow, releasing them in the circulation after maturation.
This type of stem cell has the capacity to self-renew.
(a)
These cells are present in the first few hours after an ovum is fertilized.
Totipotential stem cells
Pluripotential stem cells
Multipotential stem cells
Hematopoietic stem cells
They are the most versatile type of stem cell; can develop into any human.
(a)
Pluripotential stem cells can develop into a fetus.
True
False
These cells are derived from pluripotential stem cells.
Totipotential stem cells
Pluripotential stem cells
Multipotential stem cells
Hematopoietic stem cells
This hematopoietic developmental stage occurs during pregnancy
(a)
Mesoblastic phase begins around the (a) of embryonic development.
Mesoblastic phase is also known as (a) or primitive hematopoiesis.
Chief site of mesoblastic phase
(a)
Alpha globin chain production begins at what phase?
(a)
2 zeta 2 epsilon
Gower I
Gower II
Portland
2 epsilon 2 alpha
Gower I
Gower II
Portland
2 zeta 2 gamma
Gower I
Gower II
Portland
Hepatic phase begins at ___ to ____ gestational weeks
4;5
5;6
4;7
5;7
Hepatic phase is also known as (a)
Chief site of hepatic phase
(a)
Characterized by recognizable clusters of developing
erythroblasts, granulocytes, and monocytes colonizing the fetal liver, thymus, spleen, placenta
Mesoblastic phase
Hepatic phase
Medullary phase
Hemoglobin F
Mesoblastic phase
Hepatic phase
Medullary phase
Major site of T-cell production
(a)
Kidney and spleen produce what type of cells?
(a)
Hemoglobin F consists of 2 alpha and 2 beta globin chains
True
False
Hemoglobin A consists of 2 alpha and 2 gamma globin chains
True
False
Medullary phase occurs at the 5th week of fetal development. Hematopoiesis begins in the bone marrow cavity.
1st statement is correct, 2nd is wrong
1st statement is wrong, 2nd is correct
Both are correct
Both are wrong
Erythroid to myeloid ratio in myeloid phase
(a)
Hemoglobin A2 consists of 2 alpha and 2 delta globin chains
True
False
EPO is produced in the (a)
Hemoglobin F is still present in the medullary phase
True
False
Yellow marrow cannot develop into red marrow
True
False
Yellow marrow develops into red marrow by a process called (a)
VWF is produced by / by the ____________
liver
spleen
endothelial cells
kidney
The red bone marrows function is to produce blood cells. It is also responsible for the destruction of erythrocytes.
1st statement is correct; 2nd is wrong
1st statement is wrong; 2nd is correct
Both are correct
Both are wrong
Red bone marrow is the central organ for B lymphocyte development
True
False
Composition of stroma
endothelial cells
osteoblasts
fibroblasts
plasma cells
secrete various steroids that influence erythropoiesis and maintain bone integrity and regulates the volume of marrow
endothelial cells
adipocytes
macrophage
fibroblast
function in phagocytosis and secretion of various cytokines that regulate hematopoiesis
endothelial cells
adipocytes
macrophages
fibroblasts
regulate the flow of particles entering and leaving
hematopoietic spaces
endothelial cells
adipocytes
macrophages
fibroblasts
supports the vascular sinuses and hematopoietic cells
(a)
organ capable of extra medullary hematopoiesis
(a)
largest lymphoid organ
(a)
composed primarily of vascular sinusoids and sinuses
separated
white pulp
red pulp
marginal zone
consists of scattered follicles with germinal centers containing lymphocytes, macrophages, and dendritic cells
white pulp
red pulp
marginal zone
cells are phagocytized with subsequent degradation of cell organelles
(a)
splenic macrophages remove inclusions or damaged surface membrane from the
circulating RBCs
(a)
Lymph nodes have detoxification abilties
True
False
Regions of lymph nodes include the white pulp, red pulp, and marginal zone.
True
False
This region of lymph nodes contains follicles of B cells
(a)
This region of lymph nodes contains predominantly T cells and numerous macrophage
(a)
This region of lymph nodes consists primarily of T lymphocytes and plasma cells.
(a)
stimulates monocytes and macrophages production activity
sources are monocytes, fibroblast, Endothelial cells
(a)
a pan myeloid growth factor that stimulates Granu, - mono, megakaryocyte and eosinophil progenitors
Source is fibroblast, T cells and endothelial cells
(a)
stimulates granulocytes production and functional activation
Source : monocytes and fibroblast
(a)
(a) is a multipotential CSF that has activity same to the GM-CSF.
chromosomes 5
produced by T cells and mast cells helps EPO during erythropoiesis (example answer format: IL1)
(a) also known as eosinophil differentiation factor (EDF). It is a lineage-specific cytokine for eosinophilpoiesis. (example answer format: IL1)
(a) : mono,fibroblast, EC; Encoded by the diff. genes on chromosomes 2. It is a modulator of inflammation
(a) stimulates growth and activation of T lymphocytes, B lympho, NK; encoded on chromosome # 4 produced by activated T cells
(a) : produced by activated T cell and has a multiple activities including stimulation of B cells
(a) : T cell growth factor produced by a variety of tissue
(a) : chemotactic factor for neutrophils and T cells . It is activated by T cells
(a) : produced by activated T cells and shows activity similar to IL4
(a) : also called as high molecular weight B cells, has effect on B cell maturation.
(a) : also referred to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, is a cytokine
involved in a wide variety of biological functions. It plays an essential role in the final differentiation of B-cells into IG-secreting cells
(a) : less describe growth factor that stimulates production of immature lymphoid ( pre B and pre T) cells
stimulates thymocytes and mast cells
(a)
a T cell growth factor and mast cell activating factor that also has effect in stimulating erythroid and myeloid proliferation
(a)
stimulates NK cells , T4 and T8 cells
(a)
IL6 is encoded on chromosome # (a)
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