WorksheetsEndo Exam 2 - Corso Glycogen Glycolysis
Total questions: 57
Worksheet time: 29mins
Name
Class
Date
1.
How does most glucose enter the liver cell during high blood glucose
a)
Glut 1 transporter
b)
Glut 2 transporter
c)
Glut 3 transporter
d)
Glut 4 transporter
e)
Glut 5 transporter
2.
What happens to most glucose after it enters the liver cell
a)
phosphorylated with ATP by glucokinase to become glucose-6-phosphate and ADP
b)
phosphorylated with ATP by hexokinase to become glucose-6-phosphate and ADP
c)
phosphorylated with ATP by phosphoglucomutase to become glucose-1-phosphate and ADP
3.
What hormone increases the activity of glucokinase
a)
glucagon
b)
insulin
4.
Which glucose transporter is insulin sensitive and found on muscle and adipose cells
a)
Glut4
b)
Glut3
c)
Glut2
d)
Glut1
5.
Which glucose transporter is found on neurons
a)
Glut4
b)
Glut3
c)
Glut2
d)
Glut1
6.
Which glucose transporter is found in liver, pancreas, and intestinal cells
a)
Glut4
b)
Glut3
c)
Glut2
d)
Glut1
7.
Which glucose transporter is found on most tissues
a)
Glut4
b)
Glut3
c)
Glut2
d)
Glut1
8.
Glucokinase is found
a)
in liver cells
b)
in pancreas cells
c)
in most other cells
9.
Hexokinase is found
a)
in liver cells
b)
in pancreas cells
c)
in most other cells
10.
The reaction of glucose + ATP in the presence of glucokinase would create which product<br />
a)
fuctose
b)
fructose-1-phosphate
c)
fructose-6-phosphate
d)
glucose-1-phosphate
e)
glucose-6-phosphate
11.
Glucose-6-phosphate in the presence of the enzyme phosphoglucomutase will reversably convert some of the molecules to which other molecule
a)
glycogen
b)
UDP-glucose
c)
fructose-6-phosphate
d)
glucose-1-phosphate
e)
glucose-6-phosphate
12.
The reaction of glucose-1-phosphate with UTP in the presence of UDP-glycosepyrophosphorylase would create which other molecules (this reaction is reversable)<br />
a)
fructose-1,6-bisphosphate and UDP
b)
fructose-2,6-bisphosphate and UDP
c)
glucose-1,6-bisphosphate and UDP
d)
UDP-glucose and pyrophosphate
13.
The reaction of UDP-glucose + glycogen in the presence of active glycogen synthase produces
a)
glycogen that is one glycose larger + UDP
b)
galactose
c)
mannose
d)
sucrose
14.
Which of the following are usual features of Anderson's disease
a)
fasting hypoglycemia
b)
enlarged liver
c)
enlarged spleen
d)
can also affect muscle, heart and brain in some cases
15.
For the synthesis of glycogen, what is the correct order of chemical structures: 1. glucose-6-phosphate 2. glucose-1-phosphate 3. branched glycogen 4. glucose 5. glycogen (n+1) 6. UDP-glucose
a)
4, 1, 2, 6, 5, 3
b)
4, 2, 1, 6, 5, 3
c)
4, 5, 2, 1, 6, 3
d)
4, 6, 2, 1, 5, 3
16.
For the synthesis of glycogen, what is the correct order of enzymes used: 1. glucokinase (liver), hexokinase (muscle and other tissues) 2. UDP-glucose pyrophosphorylase 3. branching enzyme 4. glycogen synthase 5. phosphoglucomutase
a)
1, 5, 2, 4, 3
b)
1, 2, 5, 4, 3
c)
1, 4, 5, 2, 3
17.
For the liver, which of these enzymes is not reversable and is also promoted by insulin signaling
a)
glucokinase
b)
phosphoglucomutase
c)
UDP-glucose pyrophosphorylase
d)
glycogen synthase
18.
Insulin
a)
promotes glycogen synthesis
b)
promotes glycogen breakdown
19.
Glucagon
a)
promotes glycogen synthesis
b)
promotes glycogen breakdown
20.
Which disease causes muscle fatigue and has excessive normal glycogen stored in muscle
a)
McArdle's disease
b)
type zero glycogen storage disorder
c)
Glut4 transporter deficiency
d)
Her's disease
e)
Anderson's disease
21.
Which disease has decreased glycogen synthesis and fasting hypoglycemia
a)
McArdle's disease
b)
type zero glycogen storage disorder
c)
Glut4 transporter deficiency
d)
Her's disease
e)
Anderson's disease
22.
Which disease is classified by the decreased movement of glucose into muscle and fat cells
a)
McArdle's disease
b)
type zero glycogen storage disorder
c)
Glut4 transporter deficiency
d)
Her's disease
e)
Anderson's disease
23.
Which disease is indicated by an enlarged liver, fasting hypoglycemia, and excessive normal glycogen stored in the liver
a)
Pompe's disease
b)
Glut1 transporter deficiency
c)
Glut2 transporter deficiency
d)
Her's disease
e)
Anderson's disease
24.
Which disease has an enlarged liver due to reduced glycogen branching
a)
Pompe's disease
b)
Glut1 transporter deficiency
c)
Glut2 transporter deficiency
d)
Her's disease
e)
Anderson's disease
25.
Which disease is a lysosomal storage disorder where glycogen accumulates in the lysosomes
a)
Pompe's disease
b)
Glut1 transporter deficiency
c)
Glut2 transporter deficiency
d)
Her's disease
e)
Anderson's disease
26.
Which disease is indicated by a decrease of glucose entry into cells where the brain is most affected
a)
Pompe's disease
b)
Glut1 transporter deficiency
c)
Glut2 transporter deficiency
d)
Her's disease
e)
Anderson's disease
27.
Which disease is indicated by the decreased movement of glucose into and out of the liver
a)
Pompe's disease
b)
Glut1 transporter deficiency
c)
Glut2 transporter deficiency
d)
Her's disease
e)
Anderson's disease
28.
Which disease is indicated by an enlarged liver, fasting hypoglycemia, and excessive normal glycogen stored in the liver along with high glucose-6-phosphate levels
a)
Von Gierkes disease
b)
Cori's disease
c)
McArdle's disease
d)
Her's disease
e)
Anderson's disease
29.
Which disease is classified due to an enlarged liver, fasting hypoglycemia, muscle fatigue, and excessive short branched glycogen in the liver and muscle
a)
Von Gierkes disease
b)
Cori's disease
c)
McArdle's disease
d)
Her's disease
e)
Anderson's disease
30.
Alpha-1 adrenergic receptors activate
a)
PKC, promoting glycogen breakdown mostly in the liver
b)
PKA, promoting glycogen break down almost exclusively in the liver
c)
PKB, promoting glycogen synthesis mostly in liver and muscle
d)
PKA, promoting glycogen break down mostly in the muscle and liver
31.
Glucagon receptor activation activates
a)
PKC, promoting glycogen breakdown mostly in the liver
b)
PKA, promoting glycogen break down almost exclusively in the liver
c)
PKB, promoting glycogen synthesis mostly in liver and muscle
d)
PKA, promoting glycogen break down mostly in the muscle and liver
32.
Insulin receptor activation activates
a)
PKC, promoting glycogen breakdown mostly in the liver
b)
PKA, promoting glycogen break down almost exclusively in the liver
c)
PKB, promoting glycogen synthesis mostly in liver and muscle
d)
PKA, promoting glycogen break down mostly in the muscle and liver
33.
Beta-1 adrenergic receptors activate
a)
PKC, promoting glycogen breakdown mostly in the liver
b)
PKA, promoting glycogen break down almost exclusively in the liver
c)
PKB, promoting glycogen synthesis mostly in liver and muscle
d)
PKA, promoting glycogen break down mostly in the muscle and liver
34.
The reaction of glucose with ATP and hexokinase produces which two products<br />
a)
ADP
b)
AMP
c)
fructose-6-phosphate
d)
glucose-1-phosphate
e)
glucose-6-phosphate
35.
Starting with 1 molecule of glucose, how many ATP have been used after step 3
a)
1
b)
2
c)
3
d)
4
e)
5
36.
After the first 5 steps of glycolysis, glucose has ___ carbons and is phosphorylated with ___ ATPs
a)
6, 2
b)
2, 6
c)
6, 3
d)
3, 6
37.
What are the products of pyruvate, NADH and lactate dehydrogenase
a)
lactate
b)
NAD+
c)
ADP
d)
phosphoenolpyruvate
e)
ATP
38.
What are the products of ethanol, NAD+ and alcohol dehydrogenase
a)
acetaldehyde
b)
NADH
c)
acetate
d)
pyruvate
e)
lactate
39.
In the liver, during the fed state, insulin
a)
activates glycolysis
b)
activates gluconeogenesis
40.
In the liver, during the fasting state, glucagon
a)
activates glycolysis
b)
activates gluconeogenesis
41.
Glucose-6-phosphatase is activated by
a)
glycagon
b)
insulin
42.
Glucokinase is activated by
a)
glycagon
b)
insulin
43.
Pyruvate is converted to which product by the enzyme pyruvate carboxylase
a)
phosphoenol pyruvate
b)
oxaloacetate
c)
lactate
d)
glycerol
e)
glyceraldehyde-3-phosphate
44.
How many ATP's are used in the first half of glycolysis starting with 1 molecule of glucose and ending with 2 molecules of glyceraldehyde-3-phosphate
a)
1
b)
2
c)
3
d)
4
e)
5
45.
The conversion of lactate to pyruvate in the liver requires which co-substrate
a)
FAD
b)
FADH2
c)
NAD+
d)
NADH
e)
ADP
46.
The conversion of 1 molecule of glucose to 2 molecules of lactate produces which products
a)
1 ATP
b)
2 ATP
c)
2 ATP and 2 NADH
d)
4 ATP
47.
Arsenate will prevent ATP production by interfering ith which step of glycolysis? Name the enzyme for this step
a)
hexokinase
b)
glyceraldehyde-3-phosphate dehydrogenase
c)
3-phosphoglycerate kinase
d)
pyruvate kinase
e)
PFK-2
48.
How many ATP are needed to go from lactate to glucose in a liver cell
a)
2
b)
3
c)
4
d)
5
e)
6
49.
Atkins diet promotes a very low carbohydrate intake. Since the RBCs depend entirely on glucose and the brain heavily depends on glucose, what is the largest source of carbons for gluconeogenesis
a)
amino acids
b)
fatty acids
c)
glycerol
d)
lactate
e)
nucleic acids
50.
What molecule is this
a)
fructose
b)
galactose
c)
glucose
d)
mannose
51.
What is the product of this reaction
a)
b)
c)
d)
e)
52.
What is the product of this reaction with the addition of ATP
a)
fructose-1-phosphate
b)
fructose-1,6-bisphosphate
c)
glucose-1-phosphate
d)
glucose-6-phosphate
53.
What is the product of this reaction
a)
b)
c)
d)
e)
54.
What are the products of this reaction
a)
dihydroxyacetone phosphate
b)
glyceraldehyde-3-phosphate
c)
glucose-1,6-bisphosphate
d)
glucose-1-phosphate
55.
What is the product of this reaction
a)
2-phosphoglycerate
b)
3-phosphoglycerate
c)
glyceraldehyde dehydrogenase
d)
phosphoenol pyruvate
56.
What are the 2 products of this reaction
a)
2-phosphoglycerate
b)
phosphoenolpyruvate
c)
water
d)
pyruvate
57.
What is the product of this reaction
a)
b)
c)
d)
e)
100 %
