WorksheetsENDO FINAL EXAM DRUGS AND DETAILS
Total questions: 66
Worksheet time: 40mins
Which of the following drugs is the most used oral progestin and reduces blood loss by at least 80% in treating Menorrhagia?
Flomax
Tamsulosin
Dutasteride
Norethindrone
Which of the following drugs is administered every 12 weeks in the treatment of Menorrhagia?
Depo Provera
Norethindrone
Tamsulosin
Dutasteride
Which of the following is the most effective long-term medical treatment for menorrhagia and it is also and androgenic progestin, slowly released to prevent proliferation in the local endometrial environment ?
NSAIDs
Levonorgestrel-Releasing Intrauterine System
Norethindrone
Depo-Provera
Danazol
During 1st 4 months, pts may experience unscheduled spotting and bleeding, decreases after 4 months when using Levonorgestrel-Releasing Intrauterine System.
True
False
Which of the following cause downregulation of receptors leading to profound suppression of FSH and LH secretion which results in a hypogonadal stage and amenorrhea?
Gonadotropin-Releasing Hormone Agonists
Dopamine Agonists
Norethidrone
Bromocriptine
Danazol
Leuprolide, Nafarelin, Histrelin, Goserelin, Triptorelin are examples of which of the following drug class to treat Menorrhagia?
Alpha Blockers
Dopamine Agonists
Alpha - adrenergic antagonists
Gonadotropin-Releasing Hormone Agonists
Gonadotropin-Releasing Hormone Agonists have many forms of administration like monthly or quarterly injection or implant.
True
False
Which of the following drugs is a synthetic steroid with antiestrogenic that suppresses endometrial estrogen and progesterone receptors, leading to endometrial atrophy?
Cholecalciferol
Danazol
Bromocriptine
Cabergoline
Dutasteride
Danazol has limited clinical evidence, unpleasant side effects, teratogenicity.
True
False
Which of the following drugs are considered Tranexamic acid and reduces menstrual blood loss by up to 50% when treating Menorrhagia?
Danazol
Antifibrinolytics
Bromocriptine
Cabergoline
Hysterectomy is the surgical treatment for menorrhagia in women who have pelvic pathology and in women with dysfunctional uterine bleeding.
True
False
For tx with NSAIDs or oral contraceptives (dysmenorrhea).
True
False
For menorrhagia, goal is to reduce blood loss, reduce anemia risk, improve quality of life
True
False
Patients with amenorrhea or oligomenorrhea should continue to use non-hormonal contraception to prevent unintended pregnancy.
True
False
A patient between the age of 30-50 presenting difficult or painful defecation (dyschezia) and painful intercourse (dyspareunia) is a clinical presentation of?
Dysmenorrhea
Menorrhagia
Endometriosis
Amenorrhea
Patients who present with chronic pelvic pain unresponsive to conventional pain meds or initial hormonal tx should be assessed for endometriosis ASAP.
True
False
Which of the following are TRUE about Danazol? Select all that apply
Works to reduce pain
Derivative of 17-ethinyl testosterone
First approved tx for BPH, BPE and BPO
Common adverse effects seen
First approved tx for endometriosis
Which of the following drugs is a GnRH Antagonist to treat moderate to severe pain from endometriosis?
Danazol
Elagolix
Cabergoline
Bromocriptine
Which of the following are TRUE about GnRH Antagonists? Select all that apply
Decreases bone mineral density, worsens with longer use, may be irreversible
Elagolix
Danazol
Reduces 3 common types of endometriosis pain
Which of the following is the first line therapy and inexpensive to treat Endometriosis?
Medroxyprogesterone acetate
Danazol
Combined Oral Contraceptives
NSAIDs
Levonorgestrel - releasing intrauterine system
Which of the following drugs class to treat Endometriosis have a recommended duration of 6 months and maybe 24 months?
Combined Oral Contraceptives
Danazol
Levonorgestrel - releasing intrauterine system
GnRH agonists and antagonists
Which of the following can be used as a long acting contraception option for women who do not desire conception?
Elagolix
Levonorgestrel - releasing intrauterine system
Norethindrone acetate
Leuprolide acetate
Which of the following are considered Progestins? Select all that apply
Medroxyprogesterone acetate
Levonorgestrel - releasing intrauterine system
Megestrol acetate
Leuprolide acetate
Norethindrone acetate
Which of the following are considered GnRH agonists? Select all that apply
Leuprolide acetate
Norethindrone acetate
Nafarelin acetate
Goserelin acetate implant
Elagolix
Which of the following are considered an Androgen?
Leuprolide acetate
Danazol
Norethindrone acetate
Elagolix
Which of the following are true about the Causes of Infertility – Ovulation Disorders (GROUP 1)? Select all that apply
Hypothalamic pituitary failure
Amenorrhea, low gonadotropins, estrogen deficiency
Hypogonadotropic hypogonadism
Dysfunction of the hypothalamic-pituitary-ovarian axis
PCOS and hyperprolactinemic amenorrhea
Which of the following are true about the Causes of Infertility – Ovulation Disorders (GROUP 2)? Select all that apply
Dysfunction of the hypothalamic-pituitary-ovarian axis
Oligo-ovulation or anovulation; hyperandrogenism; polycystic ovaries on ultrasound scan. Hyperprolactinemia amenorrhea
Amenorrhea and low estradiol
PCOS and hyperprolactinemic amenorrhea
Which of the following are true about the Causes of Infertility – Ovulation Disorders (GROUP 3)? Select all that apply
Hypothalamic pituitary failure
Ovarian failure due to premature ovarian failure, radiation, chemotherapy, or pelvic surgery
Amenorrhea and low estradiol
Hypogonadotropic hypogonadism
Which of the following drugs stimulates ovulation causing pituitary gland to release more FSH and LH. Also, it is an Oral, nonsteroidal estrogen receptor modulator?
Cabergoline
Danazol
Clomiphene
Bromocriptine
Which of the following is an appropriate dosing for Clomiphene?
If ovulation does not occur on 1st round of treatment, 2nd dose can be increased to 200mg
50mg given daily for 5 days during cycle days 5 through 9 after spontaneous or progestin induced menses (Can also start on day 3)
Which of the following are TRUE about Clomiphene? Select all that apply
Up to 80% of pregnancies with clomiphene occur within the first 3 ovulatory cycles
If ovulation does not occur on 1st round of treatment, 3rd dose can be increased to 100mg
Should limit duration of treatment to 6 ovulatory cycles
50mg given daily for 5 days during cycle days 5 through 9 after spontaneous or progestin induced menses
Ovulation Induction
Which of the following drugs can be added if there is resistance to Clomiphene? Select all that apply
Danazol
Dexamethasone
Exogenous human chorionic gonadotropin (hCG)
Bromocriptine
DPE Inhibitors
Which of the following drugs are used for Induction of Ovulation? Select all that apply
Anastrazole
Gonadotropin-Releasing Hormones Agonist
Clomiphene
Letrozole
Gonadotropins
Which of the following drugs are considered Non-Steroidal Aromatase Inhibitors? Select all that apply
Anastrazole
Itraconazole
Letrozole
Spectazole
Ketoconazole
Which of the following has been comparable to clomiphene with respect to pregnancies, pregnancy loss, and multiple births?
Letrozole
Ketoconazole
Anastrazole
Itraconazole
Which of the following is the correct dosing for Letrozole and Anastrazole (Non-Steroidal Aromatase Inhibitors)
Taken once daily for 28 days from cycle day 3 to 7 OR cycle day 5 to 9
Taken once daily for 5 days from cycle day 3 to 7 OR cycle day 5 to 9
Which of the following is the correct dosing for Gonadotropins in a Low-dose step-up protocol?
Initial dose of 50-75 IU of FSH IM or subcutaneously. After 7-14 days, dose is increased in increments of 37.5 IU at weekly intervals
Begins with a dose of 150 IU/day of FSH until one follicle
Which of the following is the mechanism of action for Gonadotropin-Releasing Hormones Agonist?
Used to suppress spontaneous LH surge in ovulation induction procedures. Injected daily.
Used to stimulate spontaneous LH surge in ovulation induction procedures. Injected weekly.
In which of the following GnRH Antagonists there is an ALLERGY ALERT because contains dry rubber latex ? Select all that apply
Ganirelix
Cetrorelix
Trintellix
Starlix
Which of the following statements is TRUE about The Human Chorionic Gonadotropin (hCG)?
Injection usually takes place at end of ovulation induction to simulate a natural LH surge - completes final stages of follicular development and triggers ovulation.
Injection usually takes place at beginning of ovulation induction to simulate a natural LH surge - completes final stages of follicular development and triggers ovulation.
Which of the following drugs should a patient avoid if she is allergic to Peanuts?
Estrogen
Aromatase Inhibitors
Progesterone
Clomiphene
Bromocriptine
Which of the following is used in women undergoing IVF cycles to supplement endogenous progesterone?
Progesterone
Estradiol
Estrogen
Menopur
Which of the following drugs is needed for patients with PCOS to help with insulin resistance?
Glimepiride
Insulin
Glyburide
Metformin
Which of the following drugs is used when ovulation problems are caused by excess production of Prolactin (Hyperprolactinemia)?
Clomiphene Citrate
Biguanide (Metformin)
Aromatase Inhibitor (Letrozole)
Dopamine Agonist (Bromocriptine)
Cabergoline is more effective than bromocriptine, but cost is prohibitive,
True
False
Which of the following drugs is the dosing is twice weekly or weekly due to long half life?
Cabergoline
Bromocriptine
Which of the following are the different types of protocols that combine ovulation induction and ART (Assisted Reproductive Technology )? Select all that apply
Intracytoplasmic Sperm Injection (ICSI)
Prostatetocmy
In Vitro Fertilization
Intrauterine Insemination
Ovarian stimulation with fertility drugs DOES NOT increase Cancer risk.
True
False
Which of the following are NON-PHARMACOLOGIC treatments for ED (Erectile Dysfunction)? Select all that apply
Penile prostheses
Vacuum erection devices (VEDs) (Penis constriction rings)
Surgery
Proctectomy
Which of the following are considered Pharmacologic Therapies for ED? Select all that apply
Phosphodiesterase-5 (PDE-5) Inhibitors
Testosterone replacement
Alprostadil
Selected unapproved agents
Which of the following drugs are considered PDE-5 Inhibitors? Select all that apply
Sildenafil (Viagra)
Vardenafil (Levitra, Staxyn)
Tadalafil (Cialis)
Avanafil (Stendra)
Which of the following PDE-5 Inhibitors must be given 1 hr before intercourse?
Sildenafil (Viagra)
Tadalafil (Cialis)
Which of the following PDE-5 Inhibitors has little to no visual side effects like blurred vision, sensitivity to light or blue green color vision problems?
Vardenafil
Tadalafil
Avanafil
Sildenafil
Which of the following PDE-5 Inhibitors has visual effects like sensitivity to light, blurred vision, blue-green color (PDE-6 in rods and cones)? Select all that apply
Vardenafil (Levitra/Staxyn)
Sildenafil (Viagra)
Avanafil (Stendra)
Tadalafil (Cialis)
Which of the following PDE-5 Inhibitors must be given (once daily) and (30 mins before intercourse)?
Tadalafil (Cialis)
Avanafil (Stendra)
Vardenafil (Levitra/Staxyn)
Sildenafil (Viagra)
For Severe hepatic impairment avoid Tadalafil (Cialis) use.
True
False
Which of the following PDE-5 Inhibitors must be given 15-30min prior to intercourse?
Vardenafil (Levitra/Staxyn)
Tadalafil (Cialis)
Avanafil (Stendra)
Sildenafil (Viagra)
Which of the following PDE-5 Inhibitors DOES NOT have visual effects and DOES NOT decrease BP (Blood Pressure)?
Vardenafil (Levitra/Staxyn)
Avanafil (Stendra)
Sildenafil (Viagra)
Tadalafil (Cialis)
PRIAPISM is a rare adverse affects of the PDE-5 Inhibitors.
True
False
PDE-5 Inhibitors will have a drug Interaction with which of the following? Select all that apply
a-blockers
Aromatase Inhibitors
Nitrates
CYP3A4 inhibitors
If I am taking Nitrates derivates how many hours should I Hold after tadalafil?
48 hours
24 hours
If I am taking Nitrates derivates how many hours should I Hold after sildenafil & vardenafil?
24 hours
48 hours
If I am taking Nitrates derivates how many hours should I Hold after avanafil?
24 hours
12 hours
Tadalafil and avanafil – without regard to meals.
True
False
Alprostadil is the 2nd Line to PDE-5 inhibitors and VEDs.
True
False
Prostaglandin E1 stimulates adenyl cyclase - increased cAMP production - smooth muscle relaxation - enhanced blood flow and filling of corpora - erection.
Alprodastil
Danazol
