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ENDO FINAL EXAM DRUGS AND DETAILS

Total questions: 66

Worksheet time: 40mins

Name
Class
Date
1.

Which of the following drugs is the most used oral progestin and reduces blood loss by at least 80% in treating Menorrhagia?

a)

Flomax

b)

Tamsulosin

c)

Dutasteride

d)

Norethindrone

2.

Which of the following drugs is administered every 12 weeks in the treatment of Menorrhagia?

a)

Depo Provera

b)

Norethindrone

c)

Tamsulosin

d)

Dutasteride

3.

Which of the following is the most effective long-term medical treatment for menorrhagia and it is also and androgenic progestin, slowly released to prevent proliferation in the local endometrial environment ?

a)

NSAIDs

b)

Levonorgestrel-Releasing Intrauterine System

c)

Norethindrone

d)

Depo-Provera

e)

Danazol

4.

During 1st 4 months, pts may experience unscheduled spotting and bleeding, decreases after 4 months when using Levonorgestrel-Releasing Intrauterine System.

a)

True

b)

False

5.

Which of the following cause downregulation of receptors leading to profound suppression of FSH and LH secretion which results in a hypogonadal stage and amenorrhea?

a)

Gonadotropin-Releasing Hormone Agonists

b)

Dopamine Agonists

c)

Norethidrone

d)

Bromocriptine

e)

Danazol

6.

Leuprolide, Nafarelin, Histrelin, Goserelin, Triptorelin are examples of which of the following drug class to treat Menorrhagia?

a)

Alpha Blockers

b)

Dopamine Agonists

c)

Alpha - adrenergic antagonists

d)

Gonadotropin-Releasing Hormone Agonists

7.

Gonadotropin-Releasing Hormone Agonists have many forms of administration like monthly or quarterly injection or implant.

a)

True

b)

False

8.

Which of the following drugs is a synthetic steroid with antiestrogenic that suppresses endometrial estrogen and progesterone receptors, leading to endometrial atrophy?

a)

Cholecalciferol

b)

Danazol

c)

Bromocriptine

d)

Cabergoline

e)

Dutasteride

9.

Danazol has limited clinical evidence, unpleasant side effects, teratogenicity.

a)

True

b)

False

10.

Which of the following drugs are considered Tranexamic acid and reduces menstrual blood loss by up to 50% when treating Menorrhagia?

a)

Danazol

b)

Antifibrinolytics

c)

Bromocriptine

d)

Cabergoline

11.

Hysterectomy is the surgical treatment for menorrhagia in women who have pelvic pathology and in women with dysfunctional uterine bleeding.

a)

True

b)

False

12.

For tx with NSAIDs or oral contraceptives (dysmenorrhea).

a)

True

b)

False

13.

For menorrhagia, goal is to reduce blood loss, reduce anemia risk, improve quality of life

a)

True

b)

False

14.

Patients with amenorrhea or oligomenorrhea should continue to use non-hormonal contraception to prevent unintended pregnancy.

a)

True

b)

False

15.

A patient between the age of 30-50 presenting difficult or painful defecation (dyschezia) and painful intercourse (dyspareunia) is a clinical presentation of?

a)

Dysmenorrhea

b)

Menorrhagia

c)

Endometriosis

d)

Amenorrhea

16.

Patients who present with chronic pelvic pain unresponsive to conventional pain meds or initial hormonal tx should be assessed for endometriosis ASAP.

a)

True

b)

False

17.

Which of the following are TRUE about Danazol? Select all that apply

a)

Works to reduce pain

b)

Derivative of 17-ethinyl testosterone

c)

First approved tx for BPH, BPE and BPO

d)

Common adverse effects seen

e)

First approved tx for endometriosis

18.

Which of the following drugs is a GnRH Antagonist to treat moderate to severe pain from endometriosis?

a)

Danazol

b)

Elagolix

c)

Cabergoline

d)

Bromocriptine

19.

Which of the following are TRUE about GnRH Antagonists? Select all that apply

a)

Decreases bone mineral density, worsens with longer use, may be irreversible

b)

Elagolix

c)

Danazol

d)

Reduces 3 common types of endometriosis pain

20.

Which of the following is the first line therapy and inexpensive to treat Endometriosis?

a)

Medroxyprogesterone acetate

b)

Danazol

c)

Combined Oral Contraceptives

d)

NSAIDs

e)

Levonorgestrel - releasing intrauterine system

21.

Which of the following drugs class to treat Endometriosis have a recommended duration of 6 months and maybe 24 months?

a)

Combined Oral Contraceptives

b)

Danazol

c)

Levonorgestrel - releasing intrauterine system

d)

GnRH agonists and antagonists

22.

Which of the following can be used as a long acting contraception option for women who do not desire conception?

a)

Elagolix

b)

Levonorgestrel - releasing intrauterine system

c)

Norethindrone acetate

d)

Leuprolide acetate

23.

Which of the following are considered Progestins? Select all that apply

a)

Medroxyprogesterone acetate

b)

Levonorgestrel - releasing intrauterine system

c)

Megestrol acetate

d)

Leuprolide acetate

e)

Norethindrone acetate

24.

Which of the following are considered GnRH agonists? Select all that apply

a)

Leuprolide acetate

b)

Norethindrone acetate

c)

Nafarelin acetate

d)

Goserelin acetate implant

e)

Elagolix

25.

Which of the following are considered an Androgen?

a)

Leuprolide acetate

b)

Danazol

c)

Norethindrone acetate

d)

Elagolix

26.

Which of the following are true about the Causes of Infertility – Ovulation Disorders (GROUP 1)? Select all that apply

a)

Hypothalamic pituitary failure

b)

Amenorrhea, low gonadotropins, estrogen deficiency

c)

Hypogonadotropic hypogonadism

d)

Dysfunction of the hypothalamic-pituitary-ovarian axis

e)

PCOS and hyperprolactinemic amenorrhea

27.

Which of the following are true about the Causes of Infertility – Ovulation Disorders (GROUP 2)? Select all that apply

a)

Dysfunction of the hypothalamic-pituitary-ovarian axis

b)

Oligo-ovulation or anovulation; hyperandrogenism; polycystic ovaries on ultrasound scan. Hyperprolactinemia amenorrhea

c)

Amenorrhea and low estradiol

d)

PCOS and hyperprolactinemic amenorrhea

28.

Which of the following are true about the Causes of Infertility – Ovulation Disorders (GROUP 3)? Select all that apply

a)

Hypothalamic pituitary failure

b)

Ovarian failure due to premature ovarian failure, radiation, chemotherapy, or pelvic surgery

c)

Amenorrhea and low estradiol

d)

Hypogonadotropic hypogonadism

29.

Which of the following drugs stimulates ovulation causing pituitary gland to release more FSH and LH. Also, it is an Oral, nonsteroidal estrogen receptor modulator?

a)

Cabergoline

b)

Danazol

c)

Clomiphene

d)

Bromocriptine

30.

Which of the following is an appropriate dosing for Clomiphene?

a)

If ovulation does not occur on 1st round of treatment, 2nd dose can be increased to 200mg

b)

50mg given daily for 5 days during cycle days 5 through 9 after spontaneous or progestin induced menses (Can also start on day 3)

31.

Which of the following are TRUE about Clomiphene? Select all that apply

a)

Up to 80% of pregnancies with clomiphene occur within the first 3 ovulatory cycles

b)

If ovulation does not occur on 1st round of treatment, 3rd dose can be increased to 100mg

c)

Should limit duration of treatment to 6 ovulatory cycles

d)

50mg given daily for 5 days during cycle days 5 through 9 after spontaneous or progestin induced menses

e)

Ovulation Induction

32.

Which of the following drugs can be added if there is resistance to Clomiphene? Select all that apply

a)

Danazol

b)

Dexamethasone

c)

Exogenous human chorionic gonadotropin (hCG)

d)

Bromocriptine

e)

DPE Inhibitors

33.

Which of the following drugs are used for Induction of Ovulation? Select all that apply

a)

Anastrazole

b)

Gonadotropin-Releasing Hormones Agonist

c)

Clomiphene

d)

Letrozole

e)

Gonadotropins

34.

Which of the following drugs are considered Non-Steroidal Aromatase Inhibitors? Select all that apply

a)

Anastrazole

b)

Itraconazole

c)

Letrozole

d)

Spectazole

e)

Ketoconazole

35.

Which of the following has been comparable to clomiphene with respect to pregnancies, pregnancy loss, and multiple births?

a)

Letrozole

b)

Ketoconazole

c)

Anastrazole

d)

Itraconazole

36.

Which of the following is the correct dosing for Letrozole and Anastrazole (Non-Steroidal Aromatase Inhibitors)

a)

Taken once daily for 28 days from cycle day 3 to 7 OR cycle day 5 to 9

b)

Taken once daily for 5 days from cycle day 3 to 7 OR cycle day 5 to 9

37.

Which of the following is the correct dosing for Gonadotropins in a Low-dose step-up protocol?

a)

Initial dose of 50-75 IU of FSH IM or subcutaneously. After 7-14 days, dose is increased in increments of 37.5 IU at weekly intervals

b)

Begins with a dose of 150 IU/day of FSH until one follicle

38.

Which of the following is the mechanism of action for Gonadotropin-Releasing Hormones Agonist?

a)

Used to suppress spontaneous LH surge in ovulation induction procedures. Injected daily.

b)

Used to stimulate spontaneous LH surge in ovulation induction procedures. Injected weekly.

39.

In which of the following GnRH Antagonists there is an ALLERGY ALERT because contains dry rubber latex ? Select all that apply

a)

Ganirelix

b)

Cetrorelix

c)

Trintellix

d)

Starlix

40.

Which of the following statements is TRUE about The Human Chorionic Gonadotropin (hCG)?

a)

Injection usually takes place at end of ovulation induction to simulate a natural LH surge - completes final stages of follicular development and triggers ovulation.

b)

Injection usually takes place at beginning of ovulation induction to simulate a natural LH surge - completes final stages of follicular development and triggers ovulation.

41.

Which of the following drugs should a patient avoid if she is allergic to Peanuts?

a)

Estrogen

b)

Aromatase Inhibitors

c)

Progesterone

d)

Clomiphene

e)

Bromocriptine

42.

Which of the following is used in women undergoing IVF cycles to supplement endogenous progesterone?

a)

Progesterone

b)

Estradiol

c)

Estrogen

d)

Menopur

43.

Which of the following drugs is needed for patients with PCOS to help with insulin resistance?

a)

Glimepiride

b)

Insulin

c)

Glyburide

d)

Metformin

44.

Which of the following drugs is used when ovulation problems are caused by excess production of Prolactin (Hyperprolactinemia)?

a)

Clomiphene Citrate

b)

Biguanide (Metformin)

c)

Aromatase Inhibitor (Letrozole)

d)

Dopamine Agonist (Bromocriptine)

45.

Cabergoline is more effective than bromocriptine, but cost is prohibitive,

a)

True

b)

False

46.

Which of the following drugs is the dosing is twice weekly or weekly due to long half life?

a)

Cabergoline

b)

Bromocriptine

47.

Which of the following are the different types of protocols that combine ovulation induction and ART (Assisted Reproductive Technology )? Select all that apply

a)

Intracytoplasmic Sperm Injection (ICSI)

b)

Prostatetocmy

c)

In Vitro Fertilization

d)

Intrauterine Insemination

48.

Ovarian stimulation with fertility drugs DOES NOT increase Cancer risk.

a)

True

b)

False

49.

Which of the following are NON-PHARMACOLOGIC treatments for ED (Erectile Dysfunction)? Select all that apply

a)

Penile prostheses

b)

Vacuum erection devices (VEDs) (Penis constriction rings)

c)

Surgery

d)

Proctectomy

50.

Which of the following are considered Pharmacologic Therapies for ED? Select all that apply

a)

Phosphodiesterase-5 (PDE-5) Inhibitors

b)

Testosterone replacement

c)

Alprostadil

d)

Selected unapproved agents

51.

Which of the following drugs are considered PDE-5 Inhibitors? Select all that apply

a)

Sildenafil (Viagra)

b)

Vardenafil (Levitra, Staxyn)

c)

Tadalafil (Cialis)

d)

Avanafil (Stendra)

52.

Which of the following PDE-5 Inhibitors must be given 1 hr before intercourse?

a)

Sildenafil (Viagra)

b)

Tadalafil (Cialis)

53.

Which of the following PDE-5 Inhibitors has little to no visual side effects like blurred vision, sensitivity to light or blue green color vision problems?

a)

Vardenafil

b)

Tadalafil

c)

Avanafil

d)

Sildenafil

54.

Which of the following PDE-5 Inhibitors has visual effects like sensitivity to light, blurred vision, blue-green color (PDE-6 in rods and cones)? Select all that apply

a)

Vardenafil (Levitra/Staxyn)

b)

Sildenafil (Viagra)

c)

Avanafil (Stendra)

d)

Tadalafil (Cialis)

55.

Which of the following PDE-5 Inhibitors must be given (once daily) and (30 mins before intercourse)?

a)

Tadalafil (Cialis)

b)

Avanafil (Stendra)

c)

Vardenafil (Levitra/Staxyn)

d)

Sildenafil (Viagra)

56.

For Severe hepatic impairment avoid Tadalafil (Cialis) use.

a)

True

b)

False

57.

Which of the following PDE-5 Inhibitors must be given 15-30min prior to intercourse?

a)

Vardenafil (Levitra/Staxyn)

b)

Tadalafil (Cialis)

c)

Avanafil (Stendra)

d)

Sildenafil (Viagra)

58.

Which of the following PDE-5 Inhibitors DOES NOT have visual effects and DOES NOT decrease BP (Blood Pressure)?

a)

Vardenafil (Levitra/Staxyn)

b)

Avanafil (Stendra)

c)

Sildenafil (Viagra)

d)

Tadalafil (Cialis)

59.

PRIAPISM is a rare adverse affects of the PDE-5 Inhibitors.

a)

True

b)

False

60.

PDE-5 Inhibitors will have a drug Interaction with which of the following? Select all that apply

a)

a-blockers

b)

Aromatase Inhibitors

c)

Nitrates

d)

CYP3A4 inhibitors

61.

If I am taking Nitrates derivates how many hours should I Hold after tadalafil?

a)

48 hours

b)

24 hours

62.

If I am taking Nitrates derivates how many hours should I Hold after sildenafil & vardenafil?

a)

24 hours

b)

48 hours

63.

If I am taking Nitrates derivates how many hours should I Hold after avanafil?

a)

24 hours

b)

12 hours

64.

Tadalafil and avanafil – without regard to meals.

a)

True

b)

False

65.

Alprostadil is the 2nd Line to PDE-5 inhibitors and VEDs.

a)

True

b)

False

66.

Prostaglandin E1 stimulates adenyl cyclase - increased cAMP production - smooth muscle relaxation - enhanced blood flow and filling of corpora - erection.

a)

Alprodastil

b)

Danazol