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WorksheetsChapter 18 A&P 2
Total questions: 92
Worksheet time: 51mins
Definition of Stress
- secretes product into a duct, duct carries secretion into body cavity or external surface, ex.- sweat glands, oil glands, mucous glands (digestive system)
- “duct less”, secretes product into extracellular space around secretory cell, secretion then passes through membrane of cells and into the blood. ex.- pituitary, thyroid, adrenal gland, testis
- Chemical substances released from one tissue and transported by the blood to reach certain cells (target cells) in other tissues, where they exert regulatory effects on cellular processes.
- any condition that threatens homeostasis. Stressors that may cause stress include: physical, emotional, environmental, and metabolic factors
Definition of Exocrine gland
- secretes product into a duct, duct carries secretion into body cavity or external surface, ex.- sweat glands, oil glands, mucous glands (digestive system)
- “duct less”, secretes product into extracellular space around secretory cell, secretion then passes through membrane of cells and into the blood. ex.- pituitary, thyroid, adrenal gland, testis
- Chemical substances released from one tissue and transported by the blood to reach certain cells (target cells) in other tissues, where they exert regulatory effects on cellular processes.
- any condition that threatens homeostasis. Stressors that may cause stress include: physical, emotional, environmental, and metabolic factors
Definition of Endocrine gland
- secretes product into a duct, duct carries secretion into body cavity or external surface, ex.- sweat glands, oil glands, mucous glands (digestive system)
- “duct less”, secretes product into extracellular space around secretory cell, secretion then passes through membrane of cells and into the blood. ex.- pituitary, thyroid, adrenal gland, testis
- Chemical substances released from one tissue and transported by the blood to reach certain cells (target cells) in other tissues, where they exert regulatory effects on cellular processes.
- any condition that threatens homeostasis. Stressors that may cause stress include: physical, emotional, environmental, and metabolic factors
Definition of Hormone
- secretes product into a duct, duct carries secretion into body cavity or external surface, ex.- sweat glands, oil glands, mucous glands (digestive system)
- “duct less”, secretes product into extracellular space around secretory cell, secretion then passes through membrane of cells and into the blood. ex.- pituitary, thyroid, adrenal gland, testis
- Chemical substances released from one tissue and transported by the blood to reach certain cells (target cells) in other tissues, where they exert regulatory effects on cellular processes.
- any condition that threatens homeostasis. Stressors that may cause stress include: physical, emotional, environmental, and metabolic factors
-Similarities between the nervous and endocrine system
• coordinate activities
• rely on the release of proteins that bind to specific
receptors on their target cells.
• rely on the release of chemicals that bind to specific
receptors on their target cells.
• coordinate muscles
• share many chemical messengers (norepinephrine, epinephrine)
-Similarities between the nervous and endocrine system
• regulated primarily by negative feedback control mechanisms
• interrelated: they can stimulate or exhibit each other
• share a common goal: to preserve homeostasis by coordinating and regulating the activities of other cells, tissues, organs, and systems
• regulated primarily by positive feedback control mechanisms
• interrelated: they can stimulate or inhibit each other
-Differences between the nervous and endocrine system
• messengers: endocrine system’s messengers go between neurons while the nervous system’s messengers use the bloodstream for delivery
• speed: the nervous system is extremely faster than the endocrine system
• speed: the endocrine system is extremely faster than the nervous system
• messengers: nervous system’s messengers go between neurons while the endocrine system’s messengers use the bloodstream for delivery
A hormone may.....
• stimulate the synthesis of an enzyme or a structural protein not already present in the cytoplasm by activating appropriate genes in the nucleus.
• stimulate the synthesis of an enzyme or a structural neuron not already present in the cytoplasm by activating appropriate genes in the soma.
• turn an existing enzyme “on” or “off” by changing its shape or structure
• turn an existing neuron “on” or “off” by changing its shape or structure
A hormone may.....
• increase or decrease the rate of synthesis of a particular enzyme or other protein by changing the rate of transcription or translation
• increase or decrease the rate of synthesis of a particular neuron or other protein by changing the rate of transition or translation
The Endocrine system - function
affect the bodily activities by releasing chemical messengers called hormones into the blood.
affect the bodily activities by releasing enzyme messengers called hormones into the blood.
The hypothalamus regulates the activities of the nervous and endocrine system by 3 mechanisms.
it secretes regulatory hormones, which control the activities of endocrine cells in the pituitary gland
it acts as an endocrine organ by releasing hormones into the circulation at the anterior pituitary
its autonomic centers exert direct neural control over the endocrine cells of the adrenal medullae
it secretes regulatory enzymes, which control the activities of endocrine cells in the pituitary gland
it acts as an endocrine organ by releasing hormones into the circulation at the posterior pituitary
PATTERNS OF HORMONAL INTERACTION (4)
antagonistic (opposing) effects - the effects will be smaller than those produced by either hormone acting alone
antagonistic (opposing) effects - the effects will be larger than those produced by either hormone acting alone
synergistic (additive) effects - net effects are greater than either hormone acting alone
synergistic (additive) effects - net effects are greater than either hormone acting together
PATTERNS OF HORMONAL INTERACTION (4)
permissive effect - one hormone is necessary for another to produce its effect
permeable effect - one hormone is necessary for another to produce its effect
integrative effect - hormones produce different but complementary results
integrative effect - proteins produce different but complementary results
Alarm phase definition
- an immediate response, “fight or flight”, directed by the sympathetic division of the autonomic nervous system.
- eventual breakdown of homeostatic regulation and failure of one or more organ systems
Exhaustion phase definition
- an immediate response, “fight or flight”, directed by the sympathetic division of the autonomic nervous system.
- eventual breakdown of homeostatic regulation and failure of one or more organ systems
-Cause pituitary to release Thyroid-
stimulating hormone (TSH) or thyrotropin
Thyrotropin-releasing hormone TRH
Corticotropin-releasing hormone CRH
Gonadotropin-releasing hormone GnRH
Prolactin-releasing hormone PRF
Prolactin-inhibiting hormone PIH
-Causes pituitary to release Adrenocorticotropic hormone (ACTH) or coticotropin
Thyrotropin-releasing hormone TRH
Corticotropin-releasing hormone CRH
Gonadotropin-releasing hormone GnRH
Prolactin-releasing hormone PRF
Prolactin-inhibiting hormone PIH
-Causes pituitary to release Gonodotropic hormones (Follicle stimulating hormone (FSH) or follitropin, Luteinizing hormone (LH) or lutropin)
Thyrotropin-releasing hormone TRH
Corticotropin-releasing hormone CRH
Gonadotropin-releasing hormone GnRH
Prolactin-releasing hormone PRF
Prolactin-inhibiting hormone PIH
-Causes pituitary to release Prolactin (PRL) or mammotropin
-Prolactin-releasing hormone (PRF)
TRH
CRH
GnRH
PRF
PIH
-Inhibits (stops) the pituitary from releasing Prolactin (PRL) or mammotropin
-Prolactin-inhibiting hormone
TRH
CRH
GnRH
PRF
PIH
-Causes pituitary to release Growth hormone (GH) or somatotropin
-Growth hormone-releasing hormone
GH-RH
GH-IH
MSH-IH
TSH
ACTH
-Inhibits (stops) the pituitary from releasing Growth hormone (GH) or somatotropin
-Growth hormone-inhibiting hormone
GH-RH
GH-IH
MSH-IH
TSH
ACTH
-Inhibits (stops) the pituitary from releasing Melanocyte-stimulating hormone (MSH) or melanotropin
-Melanocyte-stimulating hormone-inhibiting hormone (MSH-IH)
GH-RH
GH-IH
MSH-IH
TSH
ACTH
-Causes thyroid to release thyroid hormones
-Thyroid-stimulating hormone or thyrotropin
GH-RH
GH-IH
MSH-IH
TSH
ACTH
-Causes adrenal gland to secrete glucocorticoids
-Adrenocorticotropic hormone or coticotropin
GH-RH
GH-IH
MSH-IH
TSH
ACTH
Regulate the activities of male and female gonads
Gonadotropic hormones
FSH
LH
PRL
GH
-In females: stimulate follicle development and estrogen secretion; In males: stimulates sperm production
-Follicle stimulating hormone or follitropin
Gonadotropic hormones
FSH
LH
PRL
GH
-In females: stimulates ovulation, formation of corpus luteum, and progestin production – prepare the body for possible pregnancy; In males: stimulates production of androgens (testosterone)
-Luteinizing hormone or lutropin
Gonadotropic hormones
FSH
LH
PRL
GH
-Stimulates the development of the mammary glands, and milk production
-Prolactin or mammotropin
Gonadotropic hormones
FSH
LH
PRL
GH
-Stimulates cell growth, replication and protein synthesis. Stimulates lipid mobilization and catabolism.
-Growth hormone or somatotropin
Gonadotropic hormones
FSH
LH
PRL
GH
-Increase the rate of uptake of amino acids and incorporation into new proteins, stimulates protein synthesis and cell growth
-Somatomedins or Insulin-like growth factors
IGFs
MSH
ADH
OT
T4
-Stimulates the melanocytes to produce melanin
-Melanocyte-stimulating hormone or melanotropin
IGFs
MSH
ADH
OT
T4
-Reduce water excretion, vasoconstricter (constrict peripheral blood vessels); elevate blood volume and pressure
-Antidiuretic hormone or vasopressin or arginine
IGFs
MSH
ADH
OT
T4
-In women: promotes the ejection of milk, labor contractions and delivery. In males: contractions of ductus deferens and prostate
- Oxyotocin
IGFs
MSH
ADH
OT
T4
-Speed up the Kreb’s cycle; increase: protein synthesis, oxygen consumption, growth; stimulates development of the nervous system.
-Thyroxine and Triiodothyronine
IGFs
MSH
ADH
OT
T4 and T3
-Decrease Ca2+ concentrations in the body
-Calcitonin
CT
PTH
thymosin
MC (aldosterone)
GC (cortisol)
-Increases the Ca2+ concentrations in the body
-Parathyroid hormone or parathormone
CT
PTH
thymosin
MC (aldosterone)
GC (cortisol)
Stimulate development and maturation of immune response.
CT
PTH
thymosin
MC (aldosterone)
GC (cortisol)
-Regulates electrolyte composition of bodily fluids
•Stimulates conservation of sodium ions and elimination of potassium ions
- Mineralcorticoids
CT
PTH
thymosin
MC (aldosterone)
GC (cortisol)
-Accelerate glucose synthesis and
glycogen formation; glucose-sparing effect; anti-inflammatory effect; release amino acids from skeletal muscles
CT
PTH
thymosin
MC (aldosterone)
GC (cortisol, hydrocortisone, corticosterone, cortisone)
-Increase: blood glucose, blood glycerol, fatty acids, heart rate, blood pressure, and breathing rate
-Epinephrine
E
NE
Calcitriol
EPO
Renin
-Increase: blood glucose, blood glycerol, fatty acids, heart rate, blood pressure, and breathing rate
-Norepinephrine
E
NE
Calcitriol
EPO
Renin
Stimulate calcium (Ca2+) and phosphate (PO43-) ion absorption in digestive tract
E
NE
Calcitriol
EPO
Renin
-Stimulate the production of red blood cells
-Erythropoietin
E
NE
Calcitriol
EPO
Renin
Converts
angiotensinogen --> angiotensin I
E
NE
Calcitriol
EPO
Renin
Involved in renin-angiotensin
angiotensinogen
Angiotensin I
ACE
Angiotensin II
ANP
Involved in renin-angiotensin system
angiotensinogen
Angiotensin I
ACE
Angiotensin II
ANP
-Converts angiotensin 1 to angiotensin 2
-Angtiotensin-converting enzyme
angiotensinogen
Angiotensin I
ACE
Angiotensin II
ANP
Stimulates: adrenal production of aldosterone, pituitary to secrete antidiuretic hormone (ADH)
angiotensinogen
Angiotensin I
ACE
Angiotensin II
ANP
-Promotes the loss of Na+ and water; inhibits the secretion of renin, antidiuretic hormone (ADH) and Aldosterone; suppresses thirst; blocks actions of angiotensin II or norepinephrine on arterioles
-Atrial natriuretic peptide
angiotensinogen
Angiotensin I
ACE
Angiotensin II
ANP
Increases blood glucose by—stimulating: glycogen breakdown, triglyceride breakdown, glucose production
Glucagon
Insulin
Somatosin
PP
Androgen
Lowers blood glucose by—accelerating: glucose uptake, glucose utilization and enhanced ATP production; stimulating: glycogen formation, amino acid absorption and protein synthesis, triglyceride formation
Glucagon
Insulin
Somatosin
PP
Androgen
Suppresses glucagon and insulin release; slows food absorption rates and enzyme production
Glucagon
Insulin
Somatosin
PP
Androgen
-Inhibits gallbladder contractions, regulate some pancreatic enzyme production
-Pancreatic polypeptide
Glucagon
Insulin
Somatosin
PP
Androgen
-Production of functional sperm; maintain secretory glands of male reproductive tract; stimulates: growth, protein synthesis and muscle growth; determine male secondary sexual characteristics; produce aggressive behavioral responses
-steroid sex hormones
Glucagon
Insulin
Somatosin
PP
Androgen (Testosterone)
Inhibits the secretion of follicle stimulating hormone (FSH) or follitropin
inhibin
estrogen(estradiol)
progestin (progesterone)
relaxin
melatonin
-Steroid hormone that support the maturation of oocytes, female secondary sexual characteristics, associated behaviors; and stimulate the growth of uterine lining
inhibin
estrogen(estradiol)
progestin (progesterone)
relaxin
melatonin
Prepare the uterus for the embryo, accelerate the movement of the oocyte or embryo, enlargement of the mammary glands
inhibin
estrogen(estradiol)
progestin (progesterone)
relaxin
melatonin
Loosen the pubic symphysis, permit expansion of the cervix and vagina during delivery, stimulates development of the mammary glands
inhibin
estrogen(estradiol)
progestin (progesterone)
relaxin
melatonin
Slows the maturation of sperm, oocytes, and reproductive organs by reducing the GnRH secretion rate; very effective antioxidant – protect the body from free radicals; establish daily circadian rhythms
inhibin
estrogen(estradiol)
progestin (progesterone)
relaxin
melatonin
Within the ________ hormones may circulate ______ or they may be bound to _______ carrier proteins. ____ hormones are rapidly _________ from circulation
(a)
Endocrine reflexes
are the functional counterparts of neural reflexes.
are the functional counterparts of physical reflexes.
are the action counterparts of neural reflexes.
are the action counterparts of physical reflexes.
Resistance phase definition
- an immediate response, “fight or flight”, directed by the sympathetic division of the autonomic nervous system.
- eventual breakdown of homeostatic regulation and failure of one or more organ systems
-when a stress lasts longer than a few hours, glucocorticoids are the dominant hormones
Characteristics of alarm phase
increased mental alertness
increased energy consumption
mobilization of energy reserves
decreased energy consumption
mobilization of protein reserves
Characteristics of alarm phase
increased blood flow to skeletal muscles
decreased blood flow to skin, kidneys, and digestive organs
drastic reduction in digestive and urine production
increased blood flow to skin, kidneys, and digestive organs
drastic reduction in digestive and skeletal production
Characteristics of alarm phase
increased sweat gland secretion
increased blood pressure, heart rate, and respiratory rate
decreased sweat gland secretion
decreased blood pressure, heart rate, and respiratory rate
Three groups (based on chemical structure)
Amino acid derivatives
Steroid hormones
Peptide hormones,
Cortisol derivatives
Lipid derivatives
-two groups, ex.- steroid hormones, eicosanoids
Amino acid derivatives
Peptide hormones
Lipid derivatives
- structurally similar to amino acids
ex.- epinephrine (E), norepinephrine (NE), dopamine, thyroid hormones, melatonin
Amino acid derivatives
Peptide hormones
Lipid derivatives
-chains of amino acids, two groups
ex.- shorter chain polypeptides and small proteins: antidiuretic hormone (ADH), oxytocin, growth hormone, prolactin; large glycoproteins: thyroid-stimulating hormone (TSH), luteininzing hormone, follicle-stimulating hormone (FSH)
Amino acid derivatives
Peptide hormones
Lipid derivatives
Based on the location of the receptor proteins, hormones can be grouped in three categories
The receptor proteins are located within the nucleus of the target cells
The receptor proteins are located within the cytoplasm of the target cell
The receptor proteins are located on the outer surface of the target cell membrane
The receptor proteins are located within the neuron of the target cells
The receptor proteins are located on the inner surface of the target cell membrane
Parathyroid gland
There are two cell types:
Chief cells
Oxyphils
C cells
Target cells
produce parathyroid hormone (PTH), the chief cells monitor the concentration of calcium ions. When the Ca2+ concentration is below normal, the chief cells will secrete (PTH)
Chief cells
Oxyphils
functions is unknown
Chief cells
Oxyphils
Simple endocrine reflex
- involve only one hormone
involve one or more intermediary steps and two or more hormones. ex.- hypothalamus
More-complex endocrine reflexes
- involve only one hormone
involve one or more intermediary steps and two or more hormones. ex.- hypothalamus
Anterior pituitary or adenohypophysis
derived form the endoderm
derived from the ectoderm
Posterior pituitary or Neurohypophysis
derived form the endoderm
derived from the ectoderm
Hypophyseal Portal System
the hypophyseal portal system is unusual because the capillary network carries blood to another capillary network.
arteries > capillary network > vein.
The hypophyseal portal system ensures that all the blood entering the portal vessels will reach the intended target cells before it returns to the general circulation
capillary network arteries > arteries > vein.
the hypophyseal portal system is unusual because the capillary network carries blood to another artery network.
T3 and T4 function(s):
increases the rate of energy release from carbohydrates, i.e. it speeds up the Kreb’s cycle. called a calorigenic effect - enables us to adapt to cold temperatures
increases the rate of protein synthesis
stimulates the development of the nervous system
stimulates the development of the endocrine system
decreases the rate of protein synthesis
Zona reticularis
- the endocrine cells in this zone form a folded, branching network , blood vessels wind between the cells.
-the endocrine cells in this zone form individual cords composed of stacked cells. Adjacent cords are separated by flattened blood vessels.
the endocrine cells in this zone form small, dense knots or clusters.
Zona fasciculata
- the endocrine cells in this zone form a folded, branching network , blood vessels wind between the cells.
-the endocrine cells in this zone form individual cords composed of stacked cells. Adjacent cords are separated by flattened blood vessels.
the endocrine cells in this zone form small, dense knots or clusters.
Zona glomerulosa
- the endocrine cells in this zone form a folded, branching network , blood vessels wind between the cells.
-the endocrine cells in this zone form individual cords composed of stacked cells. Adjacent cords are separated by flattened blood vessels.
the endocrine cells in this zone form small, dense knots or clusters.
Pancreatic islets has four cell types
Alpha Cells
Beta Cells
Delta Cells
F Cells
C Cells
secrete glucagon
Alpha Cells
Beta Cells
Delta Cells
F Cells
secrete insulin
Alpha Cells
Beta Cells
Delta Cells
F Cells
- secrete somatosin - a hypothalamic regulatory hormone. Somatosin suppressed glucagon and insulin release, and it also slows food absorption rates and enzyme secretion
Alpha Cells
Beta Cells
Delta Cells
F Cells
secrete pancreatic polypeptide (PP) - it inhibits gallbladder contractions, and it regulates some pancreatic enzyme production
Alpha Cells
Beta Cells
Delta Cells
F Cells
- the effects will be smaller than those produced by either hormone acting alone
antagonistic (opposing) effects
synergistic (additive) effects
permissive effect
integrative effect
net effects are greater than either hormone acting alone
antagonistic (opposing) effects
synergistic (additive) effects
permissive effect
integrative effect
one hormone is necessary for another to produce its effect
antagonistic (opposing) effects
synergistic (additive) effects
permissive effect
integrative effect
- hormones produce different but complementary results
antagonistic (opposing) effects
synergistic (additive) effects
permissive effect
integrative effect
