Antigen on the surface of pathogens found in the extracellular space

Antigen generated inside the cell as result of the cell metabolism

Endogenous antigens mistakenly recognize as non self antigens by the immune system

Antigens expressed on the surface of the infected cells by oncogenic viruses

It refers to a molecule that is capable of eliciting an immune response by an organism's immune system

It refers to a molecule that is capable of binding to the product of that immune response

It is any structure that binds to the components of the immune system including antibodies, B cells and T cells

It is a type of antigen capable of inducing an immune response

It is a molecule that reacts with specific antibody but is not immunogenic by itself

They are mainly conformational

It is where amino acid follows one another on a single chain

It results from

the folding of one chain or multiple chains,

bringing certain amino acids from different

segments of a linear sequence or sequences

into close proximity with each other so they

can be recognized together

surface antibody on B cells may

react with both linear and conformational

epitopes present on the surface of an

immunogen

It recognize an epitope only as a part

of a complex formed with MHC proteins on

the surface of an antigen presenting cell

presented on the

surface of an antigen presenting cell, where

they are bound to major histocompatibility

complex (MHC) molecules.

Epitopes that are masked when protein subunits aggregate are called?

epitopes that are only

recognized while in a specific quaternary

structure and the residues of the epitope can

span multiple protein subunits.

Epitopes are sometimes cross

reactive. This property is exploited by

the immune system in regulation by

anti-idiotypic antibodies

These are those antigens that

belong to the host

These are from other members of

the host’s species, and these are capable of

eliciting an immune response

These are from other species, such as other animals, plants or microorganisms

These are those that exist in unrelate plants or animals but which are either identical or closely related in structure so that antibody to one will cross react with antigen of the other

It is a pharmacological or immunological agent that modifies the effect of other antigens

They are only the ones approved for clinical use in the united states, and these are used to complex with the immunogen to increase its size and to prevent a rapid escape from the tissues

A gene complex encoding the major histocompatibility complex proteins in humans

Form of MHC complex that occurs in humans

The following are under what class?

HLA-1

HLA-B

HLA-C

HLA-D is under what class?

A set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility

Occurs in all vertebrates

molecule are coded for at three

different locations or loci

genes are situated in the D region,

and there are several different loci

genes are located in between class I

and class II regions

It has atleast 580 different alleles

It has at least 921 different

alleles

It has at least 312 different

alleles

It usually presents endogenous antigens to CD8+ killer T cells

It usually presents

endocytosed antigens to CD4+ helper T cells

antigen may be “cross presented” by the

other MHC class in some cases

Nucleated cell normally present peptides,

mostly self peptides derived from protein

turnover and defective ribosomal products.

These are dimers consisting of a 133 KDa alpha chain and 28Da beta chain whcih are associated by non covalent interactions

Mainly present peptides that have been synthesized within the cellt to CD8+ T cytotoxic cell

Mainly bind exogenous proteins and present it to CD4+ / T helper cell

It keeps the alpha chain in a partially folded state while it waits binding to beta 2 microglobulin

Effective for enogenous antigens

- Tumors

- Viruses

- Parasites

Effective for exogeous antigens

- Bacteria

CLASS I HLA

CLASS II HLA

Digestion of these defective or ealy proteinsis carried out by proteases that reside in large cylindrical cytoplasmic complexes called proteosomes

These are a packet of enymes that play a major role in antigen presentation

It helps TAP transported to gave close proximity to the nely formed MHC class I molecule and mediats interaction with them so that peptdes can be loaded onto the class I molecule

These are the most potent activators of T cells, and they are excellnt at capturing and digesting exogenous antigens such as bacteria

It prevent the interaction of the binding site with any endogenous peptides in the endoplasmic reticulum

It serves to protect the binding site