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Worksheets

The Quizziz That I'm not Familiar With

Total questions: 75

Worksheet time: 38mins

Name
Class
Date
1.

If the chromogen used for ALP assay is PNPP, the yellow product is due to:

a)

p-nitropyruvate

b)

p-nitrophthalate

c)

p-nitrophenol

d)

p-nitrophosphate

e)

p-nitrophrenolate

2.

Elevated blood levels of ammonia occur in all of the following disorders

EXCEPT:

a)

hepatic cirrhosis

b)

diabetes mellitus

c)

Reye’s syndrome

d)

renal failure

3.

Which reagent would not dissolve indirect bilirubin?

a)

caffeine-benzoate

b)

cetrimide

c)

methanoic acid

d)

dimethylsulfoxide (DMSO)

4.

A breakdown product of hemoglobin is:

a)

Bilirubin

b)

Bence Jones protein

c)

Hematoxylin

d)

Lipoprotein

5.

The old name for ALT is:

a)

sGPT

b)

sGOT

c)

sGNT

d)

sGTT

6.

Mesobilirubinogen, urobilinogen and stercobilinogen are collectively known

as:

a)

mesobilirubins

b)

urobilins

c)

bilirubin products

d)

urobilinogen

7.

Which of the following organs/tissues produce AST?

a)

heart

b)

RBCs

c)

kidneys

d)

liver

e)

skeletal muscles

8.

Which hepatic enzymes are generally HIGHER among obese people?

a)

ALP

b)

GGT

c)

ALT

d)

AST

e)

All of these

9.

Post-hepatic jaundice may be due to:

a)

Viral hepatitis

b)

Crigler-Najjar syndrome

c)

Rotor syndrome

d)

Gilbert syndrome

10.

Which reagent would not dissolve indirect bilirubin?

a)

dimethylsulfoxide (DMSO)

b)

methanoic acid

c)

cetrimide

d)

caffeine-benzoate

11.

It is one of the best tests for bilirubin:

a)

Jendrassik – Grof

b)

Isaacson – Jensey

c)

Reitman and Frankel

d)

Biuret

12.

The specific protein for the transport of copper present in plasma is:

a)

Ceruloplasmin

b)

Transferrin

c)

Immunoglobulin

d)

Albumin

13.

Increased levels of indirect bilirubin only is seen in:

a)

Acute quartan malaria

b)

Pancreatic tumor

c)

Bile duct obstruction

d)

Gallstones

14.

The indicator enzyme in sGOT assay be found in the _____________ cycle.

a)

tricarbonylate cycle

b)

tricarbonate cycle

c)

tricarotinic cycle

d)

tricarboxylate cycle

15.

If the total bilibirubin is 3.1 mg/dL and the conjugated bilirubin is 2.0 mg/dL.,

unconjugated bilirubin is

a)

2.2 mg/dL

b)

1.1 mg/dL

c)

0.5 mg/dL

d)

5.1 mg/dL

16.

Type I glycogen storage disease is due to a deficiency in glucose-6-

phoshatase in the liver. This condition is called:

a)

Pompe’s disease

b)

Hers disease

c)

Gaucher’s disease

d)

von Gierke’s disease

17.

If the chromogen used for ALP assay is PNPP, what wavelength is used in the

absorbance measurement?

a)

410 nm

b)

630 nm

c)

380 nm

d)

555 nm

e)

455 nm

18.

The coenzyme required in reactions involving transaminases is derived from:

a)

pyridoxine

b)

riboflavin

c)

thiamine

d)

biotin

e)

niacin

19.

Which of the following is not a function of the liver?

a)

production of hippurate and bile

b)

production of bile acids

c)

25-hydroxylation of vitamin D

d)

storage of iron

20.

Choose among these hepatic enzymes that belong to Class 1 enzymes.

a)

ALP only

b)

5'-NT

c)

OCT

d)

LDH

21.

Which hepatic enzymes are generally HIGHER in men than women?

a)

ALT

b)

GGT

c)

ALP

d)

AST

e)

All of these

22.

Which of the following serum constituents is greatly decreased if a blood

specimen is left standing at room temperature for 8 hours before processing?

a)

Glucose

b)

Carbon dioxide

c)

TAG

d)

Bilirubin

23.

Oxidation of urobilinogen by microorganisms will produce:

a)

porphobilinogen

b)

urobilin

c)

stercobilinogen

d)

protoporphyrin

24.

Which of the following enzyme pairs cannot be used in the diagnosis of liver 1/1

disorders?

a)

ACP & ALS

b)

LDH & AST

c)

GGT & 5’-NT

d)

ALP & LAP

25.

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are

both elevated in which of the following disease?

a)

urobilinogen

b)

diazobilirubin

c)

viral hepatitis

d)

muscular dystrophy

26.

A critically ill patient becomes comatose. The physician believes the coma is 1/1

due to hepatic failure. The assay most helpful in this diagnosis is:

a)

AST

b)

GCT

c)

Ammonia

d)

ALT

27.

Which hepatic enzymes is UNAFFECTED by race?

a)

ALT

b)

GGT

c)

AST

d)

ALP

28.

The sensitive enzymatic indicator for intravascular hemolysis and acute

myocardial infarction is:

a)

alanine aminotransferase (ALT)

b)

Gamma-glutamyl transferase (GGT)

c)

alkaline phosphatase (ALP)

d)

aspartate aminotransferase (AST)

29.

Which of the following enzymes are used in the diagnosis of pancreatic

cancer?

a)

Aspartate aminotransferase (AST) and leucine aminopeptidase (LAP)

b)

5’-nucleotidase (5’-NT) and gamma-glutamyl transferase (GGT)

c)

Amylase (AMS) and lipase (LPS)

d)

alanine aminotransferase (ALT) and lactate dehydrogenase (LD)

30.

Which enzyme ratio is the best indicator of acute or chronic hepatitis:

a)

LD1 /LD5 ratio

b)

AST/ALT

c)

CK-MB/total CK ratio

d)

Amylase/lipase ratio

31.

The most widely used methods for bilirubin measurement are those based on 1/1

the :

a)

Jaffe reaction

b)

8-hydroxyquinoline reation

c)

Jendrassik Grof method

d)

Schales and Schales method

32.

Type I glycogen storage disease is due to a deficiency in glucose-6-

phoshatase in the liver. This condition is called:

a)

Pompe’s disease

b)

Gaucher’s diseaseGaucher’s disease

c)

von Gierke’s disease

d)

Hers disease

33.

One of the following is used to assess liver function. Which one is it?

a)

Hippuric Acid Test

b)

Para-aminohippurate test

c)

Inulin Clearance test

d)

Creatinine Clearance Tes

34.

Which of the following tests has NO clinical application in assessing liver

function?

a)

Gamma-glutamyl transferase

b)

Triglyceride

c)

Amylase

d)

Lactate dehydrogenase isoenzymes

35.

Which hepatic enzymes are AFFECTED by dietary intake?

a)

AST

b)

ALT

c)

GGT

d)

ALP

36.

Choose the enzymes used to diagnose hepatobiliary diseases.

a)

AST only

b)

ALT only

c)

AST & ALT

d)

ALP & ACP

e)

5'-NT

37.

A serum sample was assayed for bilirubin at 10AM and the result was 12

mg/dL. The same sample was retested at 3PM. The result now is 8 mg/dL/. The

most likely explanation for this discrepancy is:

a)

The reagent has deteriorated

b)

A calculation error in the first assay

c)

The sample was exposed to light

d)

The sample was not refrigerated

38.

Which hepatic enzyme has DIURNAL VARIATION?

a)

AST

b)

ALT

c)

GGT

d)

ALP

39.

The transport material associated with bilirubin in the liver is?

a)

ligandin

b)

alpha 1 -globulin

c)

albumin

d)

beta-globulin

40.

All of the following methods have been used for the measurement of of

serum bilirubin EXCEPT:

a)

Bilirubin oxidase

b)

excretion

c)

Bilirubinometer BSP

d)

Jendrassik-Grof

41.

The polarity and water solubility of bile acids are increased upon conjugated

with:

a)

Either glycine or taurine

b)

Neither glycine not taurine

c)

Taurine

d)

Glycine

42.

Acetaminophen is particularly toxic to the:

a)

Heart

b)

Kidney

c)

Liver

d)

Spleen

43.

The indicator enzyme in sGPT assay be found in the _____________ pathway.

a)

glyoxylic

b)

glycolytic

c)

glycoxylic

d)

glycogenolytic

44.

Which of the following enzymes are used in the diagnosis of acute hepatitis?

a)

5’-nucleotidase (5’N) and gamma-glutamyl transferase (GGT)

b)

Aspartate aminotransferase (AST) and creatine kinase (CK)

c)

Amylase (AMS) and lipase (LPS)

d)

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT)

45.

Reduction of bilirubin occurs in the:

a)

Small intestine

b)

Spleen

c)

Liver

d)

Colon

46.

In the Jendrassik – Grof method for the determination of serum bilirubin

concentration, quantitation is obtained by measuring the green color of:

a)

urobilinogen

b)

bilirubin glucuronide

c)

diazobilirubin

d)

azobilirubin

47.

What enzyme system is responsible in the oxidation of bilirubin?

a)

leucine aminopeptidase

b)

glucose-6-phosphate dehydrogenase

c)

carbamoyl phosphate synthetase

d)

bacterial oxidases

48.

What substance gives feces its normal color:

a)

Stercobilin

b)

Urobilin

c)

Uroerythrin

d)

Urochrome

49.

The most heat labile fraction of alkaline phosphatase is obtained from:

a)

Bone

b)

Placenta

c)

Intestine

d)

Liver

50.

In which of the following disease states is unconjugated bilirubin NOT a majo

serum component?

a)

Neonatal jaundice

b)

Erythroblastosis fetalis

c)

Gallstones

d)

HDN

51.

In bilirubin determinations, the purpose of adding a concentrated caffeine

solution or methyl alcohol is to:

a)

Allow mixing of B1 and B2

b)

Measure total bilirubin

c)

Precipitate protein

d)

Dissolve conjugated bilirubin

52.

Indirect-reacting bilirubin may be quantified by reacting it initially in which

reagent?

a)

dilute HCl

b)

dilute sulfuric acid

c)

caffeine-benzoate

d)

sodium hydroxide

53.

In the bilirubin oxidase method, bilirubin is oxidized to a colorless compound 1/1

which is:

a)

diazotized

b)

bilierythrin

c)

sulfanilic acid

urobilinogen

d)

biliverdin

54.

Which hepatic enzymes are AFFECTED by physical exertion?

a)

AST

b)

ALT

c)

ALP

d)

GGT

55.

Which of the following functions as a transport protein for bilirubin in the

blood?

a)

alpha1 -globulin

b)

albumin

c)

beta-globulin

d)

gamma-globulin

56.

The greatest activities of serum AST and ALT are seen in:

a)

Acute viral hepatitis

b)

Alcoholic cirrhosis

c)

Metastatic pancreatic carcinoma

d)

Primary biliary cirrhosis

57.

What coenzyme is required in reactions involving transaminases?

a)

PTP

b)

PPP

c)

PLP

d)

PSP

58.

Which method uses sulfanilic acid, HCl and sodium nitrite?

a)

Zimmerman

b)

Diazo

c)

Jaffe

d)

Lowry

59.

Which of these is NOT a liver function test:

a)

Lipid profile

b)

Thymol turbidity test

c)

TP A/G ratio & BCG test

d)

hemoglobin electrophoresis

60.

Which fraction is expected to be elevated in alcoholic cirrhosis of the liver?

a)

ALP

b)

GGT

c)

ACP

d)

LDH

61.

Choose the enzymes used to diagnose parenchymal liver disorders.

a)

ALP & ACP

b)

AST but not ALT

c)

AST & ALT

d)

ALT but not AST

62.

Formation of bile acids is the major mechanism for eliminating:

a)

Triglycerides

b)

Cholesterol

c)

Bilirubin

d)

Phospholipids

63.

Which two physiological conditions are characterized by elevated serum

alkaline phosphatase?

a)

rickets, hyperthyroidism

b)

viral hepatitis, myocardial infarction

c)

growth, third trimester of pregnancy

d)

obstructive jaundice, biliary cirrhosis

64.

What class of compounds are used as substrate for ALP assays?

a)

monophosphatase

b)

paraphosphates

c)

polyphosphates

d)

pyrophosphates

e)

orthophosphates

65.

ALP & LAP concentrations are useful to assess:

a)

Intestinal malabsorption

b)

Kidney function

c)

Diabetes mellitus

d)

Hepatobiliary disease

66.

What is the immediate precursor of biliverdin?

a)

urobilinogen

b)

bilirubin

c)

heme

d)

senescent erythrocytes

67.

Total lactic dehydrogenase (LD) activity, confirmed to fraction 4 and 5 , is

most likely to be associated with:

a)

Hemolytic anemia

b)

Myocardial infarction

c)

Acute viral hepatitis

d)

Pulmonary infarction

68.

All of the following describe the direct bilirubin EXCEPT:

a)

excreted in jaundiced patients’ urine

b)

conjugated in the liver

c)

conjugated with glucuronic acid

d)

insoluble in water

69.

Which hepatic enzymes are usually HIGHER in children than ADULTS?

a)

ALP

b)

GGT

c)

ALT

d)

AST

70.

If the total bilirubin is 4.3 mg/dL and the conjugated bilirubin is 3.1 mg/dL, the

unconjugated bilirubin is:

a)

34.20 umol/L

b)

58.1 4 umol/L

c)

37.62 umol/L

d)

20.52 umol/L

71.

The principle of the tablet test for bilirubin in urine or feces is:

a)

chemical coupling of bile with a diazonium salt to form a brown color

b)

the liberation of oxygen by bile to oxidize orthotolidine to a blue-purple color

c)

chemical coupling of bilirubin with a diazonium salt to form a purple color

d)

the reaction between bile and 2,4- dichloronitrobenzene to a yellow color

72.

Kernicterus is an abnormal accumulation of bilirubin in:

a)

Brain tissue

b)

Liver tissue

c)

Kidney tissue

d)

Heart tissue

73.

What organ produce the enzyme ALT ?

a)

brain

b)

lungs

c)

liver

d)

heart

e)

muscles

74.

The term delta bilirubin refers to:

a)

Water-soluble bilirubin

b)

Direct-reacting bilirubin

c)

Free unconjugated bilirubin

d)

Bilirubin tightly bound to albumin

75.

Increased total bilirubin due to increased direct bilirubin suggests:

a)

obstructive jaundice

b)

hemolytic jaundice

c)

neonatal jaundice

d)

Crigler-Najjar syndrome