WorksheetsCardio Rem - Exam 2 - Gupta
Total questions: 55
Worksheet time: 28mins
Name
Class
Date
1.
Which lipoprotein has the highest protein composition
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
2.
Which lipoprotein has the highest cholesterol composition
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
3.
Which lipoprotein has the highest triglyceride compsosition
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
4.
Which lipoprotein carries TG from the intestine to the liver, skeletal muscle, and adipose tissue
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
5.
Which lipoprotein carries newly synthesized TG from liver to adipose tissue
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
6.
Which lipoprotein is not usually detected in the blood
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
7.
Which lipoprotein carries cholesterol from the liver cells of the body
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
8.
Which lipoprotein collects cholesterol from the body's tissues and brings it back to the liver for degradation
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
9.
What happens in the degenerative disease, atherosclerosis
a)
artery wall thickens due to the build up of lipids
b)
vein wall thickens due to the build up of lipids
c)
capillary wall thickens due to the build up of lipids
d)
artery wall thins due to lipids
e)
vein wall thins due to lipids
10.
Hyperlipidemia results in an increase concentration of lipoproteins to transport lipids in the blood causing a condition known as hyperlipoproteinemia
a)
true
b)
false (decrease in lipoprotein concentration)
11.
Which drug works as a NPC1L1 receptor blocker so that intestinal epithelial cells will decrease their absorption of cholesterol
a)
Ezetimibe
b)
Mipomersen
c)
Lomitapide
d)
Alirocumab
e)
Evolocumab
12.
Which drug inhibits mRNA responsible for the production of ApoB100 which will lead to decreased LDL and VLDL
a)
Ezetimibe
b)
Mipomersen
c)
Lomitapide
d)
Alirocumab
e)
Evolocumab
13.
Which drug inhibits MTTP to stop the creation of VLDL
a)
Ezetimibe
b)
Mipomersen
c)
Lomitapide
d)
Alirocumab
e)
Evolocumab
14.
Which drugs are used to increase the recycling of LDL-R and helping in the removal of LDL from circulation
a)
Ezetimibe
b)
Mipomersen
c)
Lomitapide
d)
Alirocumab
e)
Evolocumab
15.
Which one of the lipoproteins has three molecules of fatty acids useful for energy production when needed
a)
triglycerides
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
16.
Cholesterol esters are more lipophilic than cholesterol and are present at the outer surface of lipoproteins
a)
true
b)
false (central core is more lipophilic)
17.
Which molecule is the least lipophilic (hint: amphipathic)
a)
cholesterol
b)
colesterol fatty acid ester
c)
triglyceride<br />
d)
fatty acid
e)
phospholipid
18.
Which molecule is directly useful to the synthesis of bile acids
a)
cholesterol
b)
colesterol fatty acid ester
c)
triglyceride<br />
d)
fatty acid
e)
phospholipid
19.
What type of lipids do we eat and store
a)
triglycerides
b)
LDL
c)
HDL
d)
glucose
e)
phospholipid
20.
What is the use of apoproteins
a)
transport of lipoproteins
b)
activation of enzymes
c)
receptor binding
d)
breaking down lipoproteins
21.
Why are some cholesterol medications given at night
a)
majority of cholesterol in the liver is synthesized at night
b)
majority of cholesterol is synthesized right after waking up
c)
majority of cholesterol is synthesized during the day
22.
Why do some cholesterol lowering medications cause myopathy
a)
the more lipophilic drugs will penetrate more into the muscle
b)
the more lipophilic drugs may form a shell around muscles
c)
the more hydrophilic drugs cause spasms
23.
Why drugs can be taken at lower doses and still see improvement due to their long half-lives
a)
lipitor
b)
crestor
c)
zocor
d)
altoprev
24.
How does fish oil help lower cholesterol
a)
it decreases the biosynthesis of TG by inhibiting transcription factors
b)
it decreases biosynthesis of LDL by inhibiting transcription factors
c)
it increases biosynthesis of HDL by increasing transcription factors
25.
What vitamins are emulsified by bile salts to help their absorption
a)
vitamin A
b)
vitamin D
c)
vitamin E
d)
vitamin K
e)
vitamin C
26.
Triglycerides are present on the surface of lipoproteins<br />
a)
true
b)
false (found in the core)
27.
Which apoprotein is present on LDL
a)
ApoB 100
b)
ApoB 48
c)
Apo B11
28.
In familial hypercholesterolemia, where is the mutation
a)
ApoB 100
b)
ApoB 48
c)
Apo B11
d)
Apo A1
29.
In familial hypercholesterolemia, what is occuring
a)
LDL-R is defective
b)
PCSK9 is overactive
c)
LDL-R is missing
d)
PCSK9 is underactive
30.
What type of lipoprotein is Apo A1 present on
a)
chylomicrons
b)
VLDL
c)
IDL
d)
LDL
e)
HDL
31.
Mipomersen is a phosphorothioate oligonucleotide useful for HoFH
a)
true
b)
false (it should not be used for HoFH)
32.
Lomitapide targets which of the following enzymes essential for VLDL assembly and secretion in the liver
a)
MTTP
b)
NPC1L1
c)
cholesterol transport enzymes
d)
HMG-CoA reductase
33.
Injection site reactions are common with which drug
a)
Ezetimibe
b)
Mipomersen
c)
Lomitapide
d)
Alirocumab
e)
Evolocumab
34.
What are the categories of antihyperlipoproteinemics
a)
cholesterol absorption
b)
endogenous cholesterol biosynthesis
c)
endogenous lipoprotein and cholesterol metabolism
35.
Which HMG-CoA reductase inhibitors are prodrugs
a)
lovastatin
b)
simvastatin
c)
pravastatin
d)
atorvastatin
36.
Which HMG-CoA reductase inhibitors are active drugs
a)
lovastatin
b)
simvastatin
c)
pravastatin
d)
atorvastatin
37.
Which HMG-CoA reductase inhibitors are acidic drugs
a)
pravastatin
b)
atorvastatin
c)
fluvastatin
d)
pitavastatin
38.
Which HMG-CoA reductase inhibitors are neutral drugs
a)
lovastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
39.
Which HMG-CoA reductase inhibitors are amphoteric drugs
a)
lovastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
40.
The duration of action for statins is typically 1-4 hours except
a)
lovastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
e)
pitavastatin
41.
Which statin can be given any time of the day
a)
pravastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
e)
pitavastatin
42.
Which statins are lactones (lactone ring = prodrug)
a)
lovastatin
b)
simvastatin
c)
pravastatin
d)
atorvastatin
43.
Which statin may be a better option for geriatric patients
a)
pravastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
e)
pitavastatin
44.
Generally, all statins undergo extensive hepatic first pass metabolism except
a)
pravastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
e)
pitavastatin
45.
Which statin is called a super-statin
a)
pravastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
e)
pitavastatin
46.
Which statin can produce equipotent hydroxy metabolites
a)
pravastatin
b)
simvastatin
c)
rosuvastatin
d)
atorvastatin
e)
pitavastatin
47.
Resins are known to have an unpleasant taste
a)
true
b)
false (it has a pleasant taste)
48.
Which drug is a prodrug
a)
gemfibrozil
b)
fenofibrate
c)
fenofibric acid
49.
Which drug has the shortest DOA
a)
gemfibrozil
b)
fenofibrate
c)
fenofibric acid
50.
Which drug has significant interactions with most statins
a)
gemfibrozil
b)
fenofibrate
c)
fenofibric acid
51.
Which drug is available as a choline salt
a)
gemfibrozil
b)
fenofibrate
c)
fenofibric acid
52.
Which drug needs activation
a)
gemfibrozil
b)
fenofibrate
c)
fenofibric acid
53.
What is nicotinic acid also known as
a)
vitamin A
b)
vitamin D
c)
vitamin B
d)
omega 3
54.
Lovaza has
a)
DHA
b)
EPA
c)
Both
d)
Neither
55.
Which of the following class of drugs interfere with cholesterol absorption
a)
peroxisome proliferator-activated receptors activator
b)
cholesterol transport inhibitor
c)
HMG-CoA reductase inhibitors
d)
bile acid sequestrants
e)
omega-3 fatty acids
100 %
