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dna 3

Total questions: 96

Worksheet time: 1hrs 12mins

Name
Class
Date
1.
This scientist(s) found a "transforming principle" that changed harmless bacteria into harmful bacteria
a)
Mendel
b)
Avery
c)
Chargraff
d)
Griffith
2.
In the early 1900s, most scientists thought it was _____________ that carried traits form parent to offspring. 
a)
Carbohydrates
b)
Lipids
c)
Proteins
d)
DNA
3.
This scientist(s) conducted experiments that involved injecting mice with S bacteria and R bacteria.
a)
Avery
b)
Griffith
c)
Watson & Crick
d)
Hershey & Chase
4.
From his work with mice and pneumonia-causing bacteria, Frederick Griffin coined the term
a)
Replication
b)
Transcription
c)
Transformation
d)
Translation
5.
By using radioactive isotopes, Hershey and Chase were able to conclude that __ is/are the carrier(s) of genetic information.
a)
nucleic acid
b)
Proteins
c)
Carbohydrates
d)
Lipids
6.
The work of scientists including Griffin, Avery, Hershey & Chase and Franklin helped us to determine the __ are responsible for carrying genetic material.
a)
Amino Acids
b)
Proteins
c)
Nucleic Acids
d)
Carbohydrates
7.
Griffith discovered that
a)
DNA is different than RNA.
b)
adenine = thymine.
c)
bacteria can transfer DNA.
d)
DNA is the genetic molecule.
8.
What organism was Griffith using when he discovered that a harmless strain of bacteria could transform into a lethal strain of bacteria?
a)
pea plants
b)
fruit flies
c)
bacteriophages
d)
mice
9.

Who FIRST showed that DNA was the transforming factor?

a)

Griffith

b)

Avery

c)

Chargaff

d)

Franklin

10.
What did Avery use to destroy proteins, lipids, and carbohydrates to show that DNA was the transforming factor?
a)
Bacteriophages
b)
X-ray diffraction
c)
Enzymes
d)
Radioactive isotopes
11.
Which scientists used viruses and radioactive isotopes to definitively prove that DNA, and not protein, was the molecule of heredity?
a)
Griffith and Avery
b)
Chargaff and Franklin
c)
Watson and Crick
d)
Hershey and Chase
12.
Which two radioactive isotopes were used to label the DNA and protein components of viruses called bacteriophages?
a)
Nitrogen and Phosphorus
b)
Phosphorus and Sulfur
c)
Nitrogen and Sulfur
13.

What is a virus that infects bacteria called?

a)

bacteriophage

b)

infectious virus

c)

transformation

d)

gene change

14.

Alone, R-bacteria caused pneumonia.

a)

true

b)

false

15.

Bacteria can steal genes from other bacteria.

a)

true

b)

false

16.
Adenine bonds with ______________.
a)
Guanine
b)
Thymine
c)
Cytosine
d)
Adenine
17.

What type(s) of bacteria did Frederick Griffith work with?

a)

Heat-killed smooth pneumonia

b)

Smooth pneumonia

c)

Heat-killed rough pneumonia

d)

Rough pneumonia

18.

What occurred when Griffith injected a mouse with the rough pneumonia?

a)

The mouse lived

b)

The mouse died

19.

What occurred when Griffith injected a mouse with the smooth pneumonia?

a)

The mouse lived

b)

The mouse died

20.

What occurred when Griffith injected a mouse with heat-killed smooth pneumonia?

a)

The mouse lived

b)

The mouse died

21.

What occurred when Griffith injected a mouse with heat-killed smooth pneumonia mixed with rough pneumonia?

a)

The mouse lived

b)

The mouse died

22.
This scientist(s) found a "transforming principle" that changed harmless bacteria into harmful bacteria
a)
Mendel
b)
Avery
c)
Chargraff
d)
Griffith
23.
The scientist(s) who finally figured out the structure of DNA
a)
Avery
b)
Griffith
c)
Hershey & Chase
d)
Watson & Crick
24.
The scientist(s) who settled the debate about whether it was proteins or DNA that was the genetic material of the cell
a)
Avery
b)
Hershey & Chase
c)
Watson & Crick
d)
Griffith
25.
The scientist(s) who discovered dominant and recessive traits
a)
Mendel
b)
Avery
c)
Griffith
d)
Watson & Crick
26.
Scientist(s) who used chemical analysis to show that the genetic material in bacteria was DNA
a)
Griffith
b)
Hershey & Chase
c)
Mendel
d)
Avery
27.
In the early 1900s, most scientists thought it was _____________ that carried traits form parent to offspring. 
a)
Carbohydrates
b)
Lipids
c)
Proteins
d)
DNA
28.
This scientist(s) conducted experiments that involved injecting mice with S bacteria and R bacteria.
a)
Avery
b)
Griffith
c)
Watson & Crick
d)
Hershey & Chase
29.
The first scientist to perform multiple tests on the transforming principle, to determine if it was DNA or protein
a)
Griffith
b)
Chargraff
c)
Avery
d)
Hershey
30.
Avery added an enzyme known to break down proteins to his extract, and saw that the bacteria were ____________________
a)
still transformed
b)
not transformed
c)
all killed
d)
all sick
31.
Avery added an enzyme known to break down DNA to his extract, and saw that the bacteria were __________________
a)
still transformed 
b)
not transformed
c)
all sick
d)
all killed
32.
From his work with mice and pneumonia-causing bacteria, Frederick Griffin coined the term
a)
Replication
b)
Transcription
c)
Transformation
d)
Translation
33.
By using radioactive isotopes, Hershey and Chase were able to conclude that __ is/are the carrier(s) of genetic information.
a)
nucleic acid
b)
Proteins
c)
Carbohydrates
d)
Lipids
34.
The work of scientists including Griffin, Avery, Hershey & Chase and Franklin helped us to determine the __ are responsible for carrying genetic material.
a)
Amino Acids
b)
Proteins
c)
Nucleic Acids
d)
Carbohydrates
35.
Griffith discovered that
a)
DNA is different than RNA.
b)
adenine = thymine.
c)
bacteria can transfer DNA.
d)
DNA is the genetic molecule.
36.
What organism was Griffith using when he discovered that a harmless strain of bacteria could transform into a lethal strain of bacteria?
a)
pea plants
b)
fruit flies
c)
bacteriophages
d)
mice
37.
Who discovered the process of transformation while trying to create a vaccine against bacterial pneumonia?
a)
Griffith
b)
Avery
c)
Hershey and Chase
d)
Watson and Crick
38.

Who FIRST showed that DNA was the transforming factor?

a)

Griffith

b)

Avery

c)

Chargaff

d)

Franklin

39.
What did Avery use to destroy proteins, lipids, and carbohydrates to show that DNA was the transforming factor?
a)
Bacteriophages
b)
X-ray diffraction
c)
Enzymes
d)
Radioactive isotopes
40.
Which scientists used viruses and radioactive isotopes to definitively prove that DNA, and not protein, was the molecule of heredity?
a)
Griffith and Avery
b)
Chargaff and Franklin
c)
Watson and Crick
d)
Hershey and Chase
41.
Which two radioactive isotopes were used to label the DNA and protein components of viruses called bacteriophages?
a)
Nitrogen and Phosphorus
b)
Phosphorus and Sulfur
c)
Nitrogen and Sulfur
42.
Which scientists used viruses and radioactive isotopes to definitively prove that DNA, and not protein, was the molecule of heredity?
a)
Griffith and Avery
b)
Chargaff and Franklin
c)
Watson and Crick
d)
Hershey and Chase
43.
Who discovered the process of transformation while trying to create a vaccine against bacterial pneumonia?
a)
Griffith
b)
Avery
c)
Hershey and Chase
d)
Watson and Crick
44.
Griffith discovered that
a)
DNA is different than RNA.
b)
adenine = thymine.
c)
bacteria can transfer DNA.
d)
DNA is the genetic molecule.
45.

By using radioactive isotopes, Hershey and Chase were able to conclude that __ is/are the carrier(s) of genetic information.

a)

Nucleic Acid/DNA

b)

Proteins

c)

Carbohydrates

d)

Lipids

46.
From his work with mice and pneumonia-causing bacteria, Frederick Griffin coined the term
a)
Replication
b)
Transcription
c)
Transformation
d)
Translation
47.

Avery added an enzyme known to break down DNA to his extract, and saw that the bacteria were __________________

a)

still transformed even without DNA present

b)

not transformed because DNA carries genetic info

c)

still transformed because protein carries genetic info too

d)

all killed

48.

Avery added an enzyme known to break down PROTEINS to his extract, and saw that the bacteria were ____________________

a)

still transformed because DNA was the genetic material not protein

b)

not transformed because lipids are the genetic material

c)

all killed

d)

all of these

49.

This scientist conducted experiments that involved injecting mice with heat killed harmful bacteria and harmless bacteria and concluding that TRANSFORMATION of the harmful genes to the living harmless bacteria killed the mice.

a)

Avery

b)

Griffith

c)

Watson & Crick

d)

Hershey & Chase

50.

Hershey and Chase settled the debate about what makes up genetic material in the cell by only finding radioactive tracers on this macromolecule that were injected into bacteria by a bacteriophage.

a)

Protein

b)

DNA

c)

Carbohydrates

d)

All of These

51.

The scientist(s) who labeled viruses with radioactive tags and settled the debate about whether it was proteins or DNA that was the genetic material of the cell

a)

Avery

b)

Hershey & Chase

c)

Watson & Crick

d)

Griffith

52.

This scientist(s) destroyed the Protein, RNA and DNA of S-strain pneumonia cells to determine the "transforming principle" was DNA by process of elimination

a)

Avery

b)

Griffith

c)

Franklin & Wilkins

d)

Watson & Crick

53.

In the early 1900s, most scientists thought it was _____________ that carried traits form parent to offspring.

a)

Carbohydrates

b)

Lipids

c)

Proteins

d)

DNA

54.

Which scientist discovered transformation?

a)

Frederick Griffith

b)

Oswald Avery

c)

Alfred Hershey

d)

Martha Chase

55.

Which strain of bacteria caused pneumonia in Griffith's experiments?

a)

S-strain

b)

R-strain

c)

T-strain

d)

B-strain

56.

Which strain of bacteria was harmless in Griffith's experiments?

a)

S-strain

b)

R-strain

c)

T-strain

d)

B-strain

57.

When the mixture of heat-killed S-strain and R-strain bacteria was injected into the mice, what happened?

a)

The mice died

b)

The mice remained healthy

c)

The mice changed colors

d)

The mice got mean

58.

What is transformation?

a)

The process in which one strain of bacteria is changed by a gene or genes from another strain of bacteria

b)

The process in which one strain of bacteria is changed by a carbohydrate or carbohydrates from another strain of bacteria

c)

The process in which one strain of bacteria is changed by a protein or proteins from another strain of bacteria

d)

The process in which one strain of bacteria is changed by a lipid or lipids from another strain of bacteria

59.

Who determined that DNA was the transforming factor in Griffith's experiments?

a)

Frederick Griffith

b)

Rosalind Franklin

c)

Alfred Chase

d)

Oswald Avery

60.

What is a virus?

a)

A tiny, living particle that can infect living cells

b)

A large, living particle that can infect living cells

c)

A tiny, nonliving particle that can infect living cells

d)

A large, nonliving particle that can infect living cells

61.

What is the type of virus that infects bacteria?

a)

Invader virus

b)

Virobacteria

c)

Bacteriovirus

d)

Bacteriophage

62.

What part of the virus enters inside the bacteria?

a)

Carbohydrates

b)

Lipids

c)

Proteins

d)

DNA

63.

What is the function of bacteriophage genes?

a)

Produce more proteins

b)

Produce new bacteriophages

c)

Produce more healthy bacteria

d)

Cause pneumonia

64.

Which scientists concluded that the genetic material inside of the bacteriophage was DNA and not protein.

a)

James Watson and Francis Crick

b)

Frederick Griffith and Oswald Avery

c)

Alfred Hershey and Martha Chase

d)

Rosalind Franklin and Erwin Chargaff

65.

What are the main functions of DNA? Select all that apply.

a)

Store information

b)

Copy information

c)

Transmit information

d)

Create information

66.

Bacteriophages are

a)

a form of bacteria

b)

enzymes

c)

coils of DNA

d)

viruses

67.

Before DNA could definitively be shown to be the genetic material in cells, scientists had to show that it could

a)

tolerate high temperatures

b)

carry and make copies of information

c)

be modified in response to environmental conditions

d)

be broken down in response to environmental conditions

68.

The final proof as DNA as genetic material came from the experiment of

a)

Griffith

b)

Hershey and chase

c)

Avery, Mcleod, & McCarty

d)

Hargovind khorana

69.

Bacteriophages are

a)

Viruses

b)

Bacteria

c)

Prions

d)

Viroids

70.

Who discovered Bacteriophages

a)

Watson& Crick

b)

Felix d Herelle

c)

Laderberg

d)

Harshey & Chase

71.

Transformation is

a)

Formation of DNA from DNA

b)

Formation of mRNA from DNA

c)

Foreign DNA entryby Virus

d)

Genetic alteration of a cell

72.

Transduction is

a)

Formation of DNA from DNA

b)

Formation of mRNA from DNA

c)

Formation of Protiens from mRNA

d)

foreign DNA entry by Virus

73.

T2 bacteriophage contains-

a)

50%DNA+50%protein

b)

60%DNA+40%protein

c)

25%DNA +75%Protein

d)

75% DNA+25% Protein

74.

In Hershey Chase exp.,Protein tagging was done by-

a)

Radioactive Phosphorus P37

b)

Radioactive sulphur S 34

c)

radioactive sulphur 35 S

d)

radioactive Phosphorus 32 P

75.

In Blender exp.,DNA tagging was done by-

a)

Radioactive phosphorus P 37

b)

Radioactive sulphur S 34

c)

Radioactive sulphur S 35

d)

Radioactive Phosphorus 32 P

76.

Hershey-Chase exp.confirms that-

a)

DNA is always formed from DNA in semiconservative manner.

b)

Sulphur and Protein both enter in bacterial cell progeny.

c)

DNA is genetic material,not protein.

d)

Radioactive Phosphorus was only found in surrounding.

77.

The Bacteria used for confirmation of DNA was-

a)

Staphylococci

b)

E.coli

c)

Salmonella typhimurium

d)

Clostridium tetani

78.
By using radioactive isotopes, Hershey and Chase were able to conclude that _____ is the carrier of genetic information.
a)
DNA
b)
Protein
c)
Carbohydrate
d)
Lipid
79.

All cells contain 4 classes of macromolecules: carbohydrates, lipids, proteins, and nucleic acid's. Whose experiment showed that nucleic acids are the kind of macromolecule that codes genetic traits?

a)

griffith

b)

oswald & avery

c)

both experiments

d)

neither experiment

80.

What was the independent variable in Oswald & Avery's experiment?

a)

whether the mice were injected with living R cells or living S cells

b)

Whether the mice died of pneumonia or whether they lived

c)

Whether the molecules from killed S bacteria were treated to destroy DNA, RNA, or protein.

d)

Whether or not the R bacteria were transformed into S bacteria

81.

What was the dependent variable in Chargaff's top experiment?

a)

How the identities and percentages of different purine & pyrimidine nucleotides compared in DNA of different species

b)

Which species contributed the DNA that was analyzed

c)

Which tissue of the same organism contributed the DNA being analyzed

d)

The analysis of DNA's purine and pyrimidine content

82.

Who conducted this experiment showing that some chemical in S bacteria can control and change--transform--other bacteria to give them different genetic & hereditary characteristics?

a)

avery and his lab members

b)

griffith

c)

Franklin

d)

Chargaff

83.
Who was responsible for the experiment depicted by the image/data table?
a)
Oswald Avery, et. al.
b)
Watson and Crick
c)
Erwin Chargaff
d)
Frederick Griffith
84.
Who was responsible for the experiment depicted by the image?
a)
Friedrich (Fritz) Miescher 
b)
Hershey & Chase
c)
Frederick Griffith
d)
Oswald Avery, et. al.
85.
Scientist Griffith mixed dead, virulent,  pneumonia-causing bacteria with living, harm-less bacteria.  The harmless bacteria than infected mice with pneumonia.  This experiment showed the process of....
a)
replication
b)
transcription
c)
transformation
d)
virulination
86.
Hershey and Chase used _____ as tracers of the DNA and protein
a)
Chemiluminescence
b)
Radioactive isotopes
c)
Ions
d)
None of these are correct
87.

Who utilized the "blender experiment" in their research?

a)

Erwin Chargaff

b)

Alfred Hershey & Martha Chase

c)

Francis Crick

d)

Rosalind Franklin

88.

The final proof as DNA as genetic material came from the experiment of

a)

Griffith

b)

Hershey and chase

c)

Avery, Mcleod, & McCarty

d)

Hargovind khorana

89.

Bacteriophages are

a)

Viruses

b)

Bacteria

c)

Prions

d)

Viroids

90.

Transformation is

a)

Formation of DNA from DNA

b)

Formation of mRNA from DNA

c)

Foreign DNA entryby Virus

d)

Genetic alteration of a cell

91.

In Blender exp.,DNA tagging was done by-

a)

Radioactive phosphorus P 37

b)

Radioactive sulphur S 34

c)

Radioactive sulphur S 35

d)

Radioactive Phosphorus 32 P

92.

In Hershey Chase exp.,Protein tagging was done by-

a)

Radioactive Phosphorus P37

b)

Radioactive sulphur S 34

c)

radioactive sulphur 35 S

d)

radioactive Phosphorus 32 P

93.

Hershey-Chase exp.confirms that-

a)

DNA is always formed from DNA in semiconservative manner.

b)

Sulphur and Protein both enter in bacterial cell progeny.

c)

DNA is genetic material,not protein.

d)

Radioactive Phosphorus was only found in surrounding.

94.
Avery added an enzyme known to break down proteins to his extract, and saw that the bacteria were ____________________
a)
still transformed
b)
not transformed
c)
all killed
d)
all sick
95.
This scientist(s) conducted experiments that involved injecting mice with S bacteria and R bacteria.
a)
Avery
b)
Griffith
c)
Watson & Crick
d)
Hershey & Chase
96.
In the early 1900s, most scientists thought it was _____________ that carried traits form parent to offspring. 
a)
Carbohydrates
b)
Lipids
c)
Proteins
d)
DNA