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Genetic Mutations Review

Total questions: 74

Worksheet time: 53mins

Name
Class
Date
1.
ATTTGAGCC- Original
ATTGAGCC - Mutated
The example above is an example of a 
a)
Insertion- Frameshift
b)
Deletion- Substitution
c)
Deletion -Frameshift
d)
All of the above
2.
In a point mutation, this would have the worst effect on the function of the protein 
a)
an insertion or deletion near the end of a gene
b)
an insertion or deletion at the beginning of the gene
c)
an insertion at the middle of the gene
d)
a base substitution
3.
Which of the following would result in a frameshift mutation?
a)
Insertions only
b)
Substitution only
c)
Deletion only
d)
Insertions and Deletions
4.
Why is the order of amino acids so important?
a)
The order of amino acids dictates what shape the protein will fold into.
b)
It is not important. The protein folding chamber will force the protein to fold into the correct shape.
5.
What mutation has occurred here? 
T-G-A-C-C-A
T-G-A-G-C-A
a)
Substitution
b)
Deletion
c)
Insertion
d)
Frameshift 
6.
Any change in the sequence of DNA is...
a)
transgenic shift
b)
Single Genotype
c)
Monohybrid Trait
d)
Mutation
7.
What is the three base sequence of mRNA that codes for a single amino acid?
a)
Anticodon
b)
Codon
c)
Protein
8.

Which of the following is the least likely number to represent how many amino acids are coded for by this sequence of nucleotides?

ATGGGAACTCCA

a)

4

b)

2

c)

3

d)

12

9.
How many codons are needed to specify for five amino acids?
a)
3
b)
5
c)
15
d)
30
10.
21 nucleotides will provide how many codons?
a)
3 amino acids
b)
5 amino acids
c)
7 amino acids
d)
9 amino acids
11.

What type of mutation happens to just one base.

a)

Chromosome Mutation

b)

Point Mutation

c)

DNA Mutation

d)

Deletion Mutation

12.

What point mutation changes one base?

a)

Substitution

b)

Insertion

c)

Deletion

13.

What point mutation adds one base?

a)

Substitution

b)

Deletion

c)

Insertion

14.

What point mutation removes one base?

a)

Deletion

b)

Insertion

c)

Substitution

15.

What is it called when a point mutation messes up several amino acids?

a)

Chromosomal Mutation

b)

Reading Frame Mutation

c)

Frameshift Mutation

d)

Amino Acid Mutation

16.

What is it called when a point substitution mutation has no effect?

a)

Substitution Mutation

b)

No Mutation

c)

Silent Mutation

17.

What is a mutation?

a)

A change in a chromosomal region.

b)

A negative change in the nucleotide sequence of DNA.

c)

A change in one base pair in DNA.

d)

Any change in the nucleotide sequence of DNA.

18.

Match the following Mutations

a)

Deletion

1.

Entire sequence shifts to the left

b)

Insertion

2.

Entire sequence shifts to the right

c)

Substitution

3.

One Nucleotide is swapped for another

d)

Point

4.

Only one nucleotide is affected

e)

Frameshift

5.

More than one nucleotide is affected and entire sequence shifts

19.

Match the following Mutations

a)

Missense

1.

Causes chance in amino acid sequence ; results in different protein

b)

Nonsense

2.

Causes an amino acid to change into a "STOP" codon

c)

Silent

3.

Has no effect on amino acids or proteins

20.

What type of mutation is this?

a)

Nonsense

b)

Missense

c)

Silent

21.

What type of mutation is this?

a)

Substitution

b)

Deletion

c)

Insertion

22.

What type of mutation is this?

a)

Point

b)

Frameshift

23.
Which of the following would result in a frameshift mutation?
a)
Insertions only
b)
Substitution only
c)
Deletion only
d)
Insertions and Deletions
24.

chromosomal mutations cause a segment of the chromosome to repeat itself during replication.

a)

inversion

b)

duplication

c)

translocation

d)

deletion

25.
Original: ATC CAT
Mutation: ATC GCAT
What mutation occurred?
a)
deletion
b)
insertion
c)
silent
d)
transverse
26.
Original DNA: CAT GAT
New DNA: CAT AT
What mutation occurred?
a)
deletion
b)
substitution 
c)
tranverse
d)
insertion
27.
Gene: ABC
New Gene: BBC
What mutation
a)
deletion
b)
insertion
c)
substitution
d)
transversion
28.
What type of gene mutation results from the insertion or deletion of nucleotides and alters the entire amino acid sequence from that point forward?
a)
Frameshift
b)
Missense
c)
Nonsense
d)
Silent
29.
Which of the following mutations results in a non-functional protein because a stop codon appeared too early in the mRNA sequence?
a)
Frameshift
b)
Missense
c)
Nonsense
d)
Silent
30.

Mutations that involve parts of or all of

a chromosome

a)

Replication

b)

Deletion Mutation

c)

Chromosomal Mutation

d)

Transcription

31.

Part of a chromosome is reversed.

a)

Inversion Mutation

b)

Deletion Mutation

c)

Translocation

d)

Point Mutation

32.

Part of one chromosome is transported and attached

to a non-homologous chromosome

a)

Inversion Mutation

b)

Translocation Mutation

c)

Duplication Mutation

d)

Point Mutation

33.
Where do mutations occur?
a)
DNA and RNA
b)
DNA 
c)
RNA
d)
mRNA and tRNA
34.

Point mutation involves

a)

deletion

b)

insertion

c)

duplication

d)

changes in single base pair

35.

Part of a chromosome is reversed.

a)

Inversion Mutation

b)

Deletion Mutation

c)

Translocation

d)

Point Mutation

36.

Part of a chromosome is repeated

a)

Gene Mutation

b)

Point Mutation

c)

Deletion Mutation

d)

Duplication Mutation

37.

Part of one chromosome is transported and attached

to a non-homologous chromosome

a)

Inversion Mutation

b)

Translocation Mutation

c)

Duplication Mutation

d)

Point Mutation

38.
What type of gene mutation has occurred here? Normal-
AGA-TTC-ATA-GCG
Mutant-
AGA-TTC-AAT-AGC-G
a)
deletion frameshift
b)
insertion frameshift
c)
substitution
d)
nonsense
39.
Any change in the sequence of DNA is...
a)
transgenic shift
b)
Single Genotype
c)
Monohybrid Trait
d)
Mutation
40.
What type of gene mutation has occurred here? 
T-G-A-C-C-A
T-G-A-C-C-A-A
a)
Base Substitution
b)
Base Deletion
c)
Base Insertion
d)
Frameshift 
41.
Where do mutations occur?
a)
DNA and RNA
b)
DNA 
c)
RNA
d)
mRNA and tRNA
42.
A type of substitution in which no amino acids change is called 
a)
Missense
b)
Nonsense
c)
Silent
d)
Deletion
43.
What is the correct mRNA strand from this DNA?
CAC-GTG-ACA-GCG
a)
GTG-CAC-TGT-CGC
b)
CAC-GUG-ACA-GCG
c)
GUG-CAC-UGU-CGC
44.
Are all mutations bad?
a)
Yes
b)
No
c)
Maybe?
45.
What mutation has occurred here? 
T-G-A-C-C-A
T-G-A-G-C-A
a)
Substitution
b)
Deletion
c)
Insertion
d)
Frameshift 
46.

Mutations can be...

a)

Harmful

b)

Beneficial

c)

Neutral

d)

All of the Above

47.

The bottom DNA sequence in the image has been altered by this type of mutation

a)

substitution

b)

insertion

c)

deletion

d)

translocation

48.

In this type of point mutation, one extra base pair is inserted into a sequence of DNA

a)

substitution

b)

insertion

c)

deletion

d)

translocation

49.

The bottom DNA sequence in the image has been altered by this type of mutation

a)

substitution

b)

insertion

c)

deletion

d)

translocation

50.

Original: ATC CAT

Mutation: ATC GCAT

What mutation occurred?

a)

deletion

b)

insertion

c)

silent

d)

transverse

51.
What are the three types of mutation? 
a)
Insertion, Deletion, Subsitution
b)
Deletion, Newstion, Subsitution 
c)
Newstion, Deletion, Insertion 
d)
Insertion, Newstion, Substitution 
52.
Are all mutations bad?
a)
Yes
b)
No
53.

Mutations are__________

a)

Harmful

b)

Harmful or beneficial

c)

Neutral

d)

Harmful, neutral, or beneficial

54.

What are the three types of gene mutation?

a)

Insertion, Deletion, Subsitution

b)

Aberration, Deletion, Substitution

c)

Inversion, Duplication, Insertion

d)

Insertion, Duplication, Substitution

55.

A substitution mutation that has no effect

on an amino acid's sequence would be best categorized as:

a)

Insertion Mutation

b)

Translocation

c)

Silent Mutation

d)

Deletion Mutation

56.

The image shown depicts a point mutation. Which of the following categories best describes this mutation?

a)

Missense

b)

Nonsense

c)

Silent

d)

Neutral

57.

How many nucleotides are involved in a point mutation?

a)

1

b)

2

c)

3

d)

4

58.

What type of mutation happens to just one base.

a)

Chromosome Mutation

b)

Point Mutation

c)

DNA Mutation

d)

Deletion Mutation

59.

What point mutation changes one base?

a)

Substitution

b)

Insertion

c)

Deletion

60.

What point mutation adds one base?

a)

Substitution

b)

Deletion

c)

Insertion

61.

What point mutation removes one base?

a)

Deletion

b)

Insertion

c)

Substitution

62.

What is it called when a point mutation messes up several amino acids?

a)

Chromosomal Mutation

b)

Reading Frame Mutation

c)

Frameshift Mutation

d)

Amino Acid Mutation

63.

Which types of point mutations mess up several amino acids?

a)

Insertion

b)

Substitution

c)

Deletion

d)

Silent

64.

What is it called when a point substitution mutation has no effect?

a)

Substitution Mutation

b)

No Mutation

c)

Silent Mutation

65.

What is a mutation?

a)

A change in a chromosomal region.

b)

A negative change in the nucleotide sequence of DNA.

c)

A change in one base pair in DNA.

d)

Any change in the nucleotide sequence of DNA.

66.

What is mutagenesis?

a)

Multiple mutations.

b)

The production of mutations.

c)

Mutations that are gene specific.

d)

The study of mutations.

67.

When do mutations occur?

a)

During DNA replication.

b)

During protein synthesis.

c)

A mutation can occur any time.

68.

What type of mutation changes the structure of chromosomes?

a)

Multiple Point Mutations

b)

Chromosomal Mutation

c)

Structural Mutation

69.

What type of chromosomal mutation loses genes?

a)

Duplication

b)

Inversion

c)

Deletion

d)

Translocation

70.

What type of chromosomal mutation gains a copy of the same genes it already has?

a)

Duplication

b)

Inversion

c)

Deletion

d)

Translocation

71.

What type of chromosomal mutation removes genes and then re-attaches the genes backwards?

a)

Duplication

b)

Inversion

c)

Deletion

d)

Translocation

72.

What type of chromosomal mutation gains extra genes that it did not have before?

a)

Duplication

b)

Inversion

c)

Deletion

d)

Translocation

73.

What does a nonsense mutation do?

a)

Change one amino acid to a stop codon.

b)

Change one amino acid to a different amino acid.

c)

Change one amino acid to a start codon.

74.

What does a missense mutation do?

a)

Change one amino acid to a stop codon.

b)

Change one amino acid to a different amino acid.

c)

Change one amino acid to a start codon.

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