wayground logo

Free Printable Worksheets

Font size

S
M
L
XL
Worksheets

Biology chpt 11 DNA Replication and Cell Division

Total questions: 78

Worksheet time: 1hrs 2mins

Name
Class
Date
1.
The enzyme that unzips the DNA to prepare for replication
a)
helicase
b)
replicase
c)
polymerase
d)
synthase
2.
Which enzyme is responsible for adding nucleotides?
a)
Topoisomerase
b)
DNA Polymerase
c)
Ligase
d)
Primase
3.
Which enzyme is responsible for adding nucleotides?
a)
Topoisomerase
b)
DNA Polymerase
c)
Ligase
d)
Primase
4.
The process of DNA replication is called semi conservative because it results in
a)
none of these
b)
Two DNA molecules.  One original molecule and one with two new strands
c)
two exact copies with new strands
d)
two identical molecules, each with 1 original strand and one new.
5.
Which enzyme seals okazaki fragments together on the lagging strand?
a)
Topoisomerase
b)
Helicase
c)
Polymerase
d)
Ligase
6.
What is A?
a)
Leading strand
b)
Lagging strand
c)
Okazaki Fragments
d)
DNA plymerase
7.
Small segments of DNA made on the lagging strand are called:
a)
Okazaki Fragments
b)
ERVs
c)
Transposable Elements
d)
Telomeres
8.
If a strand reads:
3' A A A T T T C 5'
The matching strand would read...
a)
5' T T T A A A G 3'
b)
3' T T T A A A G 5'
c)
5' A A A T T T C 3'
d)
3' U U U A A A G 5'
9.
Which of the following must happen first in order for DNA replication to occur?
a)
DNA polymerase binds to the leading strand
b)
DNA is unwound
c)
Hydrogen bonds form between bases
d)
chromosomes condense
10.
Which of the following is required for DNA replication to occur?
a)
DNA helicase
b)
DNA ligase
c)
DNA polymerase
d)
all of these
11.

The separation of the two single strands of DNA creates a ‘Y’ shape?

a)

enzyme

b)

unzip

c)

A replication fork

12.

Structure C is

a)

helicase

b)

primase

c)

DNA polymerase III

d)

gyrase

13.
The enzyme that unwinds the DNA to prepare for replication
a)
helicase
b)
replicase
c)
polymerase
d)
synthase
14.

DNA is synthesized in the ... direction, and read in the ... direction.

a)

5' to 3, 5' to 3'

b)

3' to 5', 3' to 3'

c)

5' to 3', 3' to 5'

15.

Select all that are true about DNA Polymerase

a)

Synthesize 5' to 3' direction only

b)

Can synthesize RNA

c)

Synthesize 3' to 5' direction only

d)

Cannot initiate synthesis de novo

16.

Why can't DNA Polymerase initiate synthesis de novo?

a)

It actually can

b)

It needs a primer

c)

DNA strands are antiparallel

d)

mRNA is not processed

17.

Telomerase is needed to prevent the loss of essential genes in DNA replication

a)

True

b)

False

18.

The short segments of newly synthesized DNA making the lagging strand are called?

a)

ORI

b)

Okazaki fragments

c)

Lagging fragments

d)

Telomeres

19.

Types of strands in DNA replication

a)

Linear strand

b)

Leader strand

c)

Leading strand

d)

Lagging strand

20.

Okazaki Fragment is formed at the

a)

Lagging strand

b)

Leading strand

c)

Linear strand

d)

Leader strand

21.

Telomeres ____________ chromosome length.

a)

lengthen

b)

shorten

22.
After analyzing a sample of DNA, a scientist recorded the data shown in the table. What percentage of the DNA sample is cytosine?
a)
22%
b)
25%
c)
28%
d)
56%
23.

If a person suffered from a disorder where their DNA fragments were unable to fill in the missing slots in between the fragments of the lagging strand, they would most likely have a disorder that affected which enzyme?

a)

DNA Helicase

b)

DNA Ligase

c)

DNA polyermase

d)

RNA Polymerase

24.

Which letter in the picture below depicts the replication fork in DNA replication?

a)

A

b)

C

c)

B

d)

None of the above

25.

Which enzyme is responsible for forming phosphodiester bonds between the Okazaki fragments?

a)

Ligase

b)

Helicase

c)

DNA Polymerase 1

d)

DNA Polymerase 3

26.

Which of the following is TRUE of the leading strand?

a)

It contains Okasaki fragments

b)

It needs ligase

c)

It is synthesized towards the replication fork

d)

It is synthesized in the 3' to 5' direction

27.

The directionality of DNA is said to be ___________, because it is side by side by goes in opposite directions.

a)

Anti-directional

b)

Parallel

c)

Anti-parallel

d)

Anti-uniform

28.

The picture below shows an enzyme unwinding and unzipping DNA.

​

​What is the name of this enzyme?

a)

Helicase

b)

DNA Ligase

c)

DNA polymerase

d)

RNA Polymerase

29.

Which letter in the picture below depicts the leading strand in DNA replication?

a)

A

b)

C

c)

B

d)

None of the above

30.

Which letter in the picture below depicts the lagging strand in DNA replication?

a)

A

b)

C

c)

B

d)

None of the above

31.

Where does DNA replication occur in prokaryotes?

(a)  

32.

Where does DNA occur in eukaryotes?

(a)  

33.

How many sites of origin do prokaryotes have when replicating their DNA?

(a)  

34.

Prokaryotic cells have circular DNA and eukaryotic cells have linear DNA. What is the characteristic of their DNA related into this?

a)

Procaryotic cells have single origin of replication and eukaryotic cells have several origin of replication

b)

Prokaryotic cells have telomers and eukaryotic cells don't have telomers

35.

Discuss the structure of DNA in prokaryotes.

a)

The structure of DNA in prokaryotes is typically circular and organized into operons.

b)

DNA in prokaryotes is made up of histones.

c)

Prokaryotic DNA is stored in the nucleus.

d)

The structure of DNA in prokaryotes is linear and disorganized.

36.

What would happen if primase was dysfunctional?

a)

The hydrogen bonds of the double helix would reform

b)

RNA primer would not be laid down

c)

The Okasaki fragments would not be fused

d)

Twisting tension would damage the DNA

37.

What part of the cell cycle is considered interphase? Select all that apply.

a)

G1

b)

G2

c)

S

d)

M

38.

Two identical chromatids are called...

a)

Daughter Chromatids

b)

Sister Chromatids

c)

Brother Chromatids

d)

Twin Chromatids

39.

How are the centromere and telomere different?

a)

The centromere is the center of the chromosome, the telomeres are the ends

b)

The centromere is at the ends of the chromosomes, the telomere is at the center

c)

The centromere is larger than the telomere

d)

The telomere is larger than the centromere

40.

What happens to telomeres when cells divide?

a)

Telomeres get shorter.

b)

Telomeres get longer.

c)

None of these.

41.

True or False. Longer telomeres are indicative of older cells.

a)

True

b)

False

42.

The correct sequence of mitosis:

a)

metaphase, anaphase, telophase, prophase

b)

prophase, metaphase, anaphase, telophase

c)

prophase, anaphase, metaphase, telophase

d)

telophase, metaphase, prophase, anaphase

e)

None of these

43.
Identify the Cell Cycle Stage.
a)

Anaphase

b)

Cytokinesis

c)

Telophase

d)

Metaphase

e)

None of these

44.
Identify the Cell Cycle Stage.
a)

Interphase

b)

Anaphase

c)

Telophase

d)

Prophase

e)

None of these

45.
If the "2n" number is 10, how many chromosomes do gametes have?
a)
10
b)
5
c)
20
d)
15
46.
The longest phase of the cell cycle 
a)
prophase
b)
interphase
c)
metaphase
d)
mitosis
47.
Which is the correct order?
a)
C,D, B, A, F, E
b)
D,A,F,C,E,B
c)
B,E,C,F,A,D
d)
C,B,D,A E,F
48.

The structures labeled B are

a)

centrioles

b)

sister chromatids

c)

centromeres

d)

chromopheres

49.

The cell cycle consists of the G1, S, G2, and the _____ phase.

a)

G3

b)

M

c)

G4

d)

A

50.

During G1 phase,

a)

DNA synthesized

b)

organelles synthesized

c)

centrosome duplicates

d)

chromosome duplicates

51.

DNA condenses during

a)

Interpahse

b)

Prophase/prometaphase

c)

metaphase

d)

anaphase

e)

telophase

52.

The longest phase in cell cycle is

a)

G1 phase

b)

G2 phase

c)

S phase

d)

M phase

53.

Cytokinesis occurs during

a)

G1 phase

b)

S phase

c)

G2 phase

d)

M phase

54.

Sister chromatids are created during

a)

G1 phase

b)

S phase

c)

G2 phase

d)

M phase

55.

Which of the following pairs is correctly matched?

I : Anaphase I - Homologous chromosome are seperated

II : Metaphase I - synapsis and crossing over occur

III : Prophase I - Homologous chromosomes are line up at equator plane

IV : Telophase I - Chromatin starts to condense and become visible

a)

I

b)

II

c)

III

d)

IV

56.
How does cytokinesis differ in plant and animal cells?
a)
Cytokinesis only takes place in animal cells.
b)
Cytokinesis only takes place in plant cells.
c)
Plant cells form a cell plate, animal cells form a cleavage furrow.
d)
Animal cells form a cell plate, plant cells form a cleavage furrow.
57.

Which molecules act as gatekeepers for each checkpoint of the cell cycle?

a)

p53 gene

b)

cyclins and cycline-dependent kinases

c)

thyroid hormones

58.

How many cell cycle checkpoints are there?

a)

1

b)

2

c)

3

d)

4

59.
Uncontrolled cell division is stopped by...
a)
tumor suppressor genes
b)
oncogenes
60.
Which is an example of a tumor suppressor gene?
a)
apoptosis
b)
proto-oncogenes
c)
p53
d)
oncogenes
61.
This is the cell cycle checkpoint that makes sure DNA has been replicated correctly during S phase.
a)
G1 Checkpoint
b)
G2 Checkpoint
c)
M Checkpoint
d)
I Checkpoint
62.

Which one of these is characteristic of cancer cells?

a)

They undergo apoptosis.

b)

They do not respond to growth inhibitors

c)

They respond to growth inhibitors.

63.

Which is a function of cyclins?

a)

Cyclins are carbohydrates that regulate DNA replication during the mitosis phase of the cell cycle.

b)

Cyclins are glycoproteins that repair DNA in the beginning of cell cycle.

c)

Cyclins are proteins that regulate when and how often a cell divides.

64.

What is checked at the G1 checkpoint in the cell cycle?

a)
Cell shape, oxygen levels, cell division, and protein synthesis
b)

Chromosome number, cell volume, enzyme activity, and cell membrane

c)
Cell polarity, pH levels, organelle function, and cell signaling
d)
Cell size, nutrients, growth factors, and DNA damage
65.

Which checkpoint ensures that DNA replication is complete and the replicated DNA is not damaged?

a)
G1 checkpoint
b)
G2 checkpoint
c)
S checkpoint
d)
M checkpoint
66.

What happens if a cell receives a go-ahead signal at the G1 checkpoint?

a)
It will enter a state of dormancy.
b)
It will skip the S phase and proceed directly to mitosis.
c)
It will proceed to the S phase of the cell cycle.
d)
It will self-destruct.
67.

Which checkpoint ensures that all chromosomes are attached to spindle fibers before proceeding to anaphase?

a)

G1 checkpoint

b)

G2 checkpoint

c)

S checkpoint

d)

M checkpoint

68.

Which molecule acts as a go-ahead signal at cell cycle checkpoints?

a)
Cellular division kinase (Cdk)
b)
Cyclin-dependent kinase (Cdk)
c)
Cyclin-dependent receptor (Cdr)
d)
Cycle-regulating protein (Crp)
69.

What will happen if any chromosomes are not attached to spindle fibers during mitosis?

a)
Spindle fibers will detach from centromeres
b)
Cells will undergo apoptosis
c)

The cell will receive a stop signal

d)
Chromosomes will replicate
70.

What gene is activated in response to DNA damage or cell cycle abnormalities?

a)

p21

b)
BRCA1
c)
RB1
d)
p53
71.

What is the primary role of the p53 gene when activated?

a)

Encode a protein activator that activates other genes

b)
Induction of apoptosis
c)
Inhibition of DNA repair
d)
Promotion of cell growth
72.

Which gene is activated by the protein produced by the p53 gene?

a)
p73
b)
p53R2
c)
p63
d)
p21
73.

What does the p21 gene encode for?

a)

Cyclin-dependent kinase inhibitor

b)

DNA repair enzyme

c)

Spindle fiber

d)
Cyclin-dependent kinase inhibitor 2A (CDKN2A)
74.

What is the consequence of the Cdk inhibitor binding to Cdks?

a)
It prevents the activation of Cdks and halts the cell cycle progression.
b)
It leads to the degradation of Cdks and promotes cell division.
c)
It has no effect on Cdks and allows the cell cycle to continue normally.
d)
It enhances the activation of Cdks and speeds up the cell cycle progression.
75.

Why is it important to arrest the cell cycle when DNA damage is detected?

a)
To enhance DNA damage spread
b)
To increase cell division rate
c)

To allow time for DNA repair

d)
To speed up the repair process
76.

What might happen if the p53 gene is mutated and non-functional?

a)
Decreased risk of cancer development and enhanced ability to repair damaged DNA
b)
No impact on cancer risk or DNA repair capabilities
c)
Increased risk of cancer development and inability to repair damaged DNA
d)
Increased risk of heart disease and improved immune function
77.

What is the main function of the p53 protein in the cell cycle?

a)

To initiate DNA replication

b)

To promote cell growth

c)

To act as a tumor suppressor by regulating the cell cycle

d)

To assist in chromosome separation during mitosis

78.

What is the result of a functional p53 gene in the presence of DNA damage?

a)

The cell cycle progresses without interruption

b)

DNA replication is halted and repair mechanisms are activated

c)

  • The cell immediately enters mitosis

d)

Spindle fibers are detached from chromosomes

Similar Resources on Wayground

Final Review

80 questions

Final Review

quiz

Worksheet

•

KG - University

Cardiac Anatomy & Physiology

75 questions

Cardiac Anatomy & Physiology

quiz

Worksheet

•

University

Photosynthesis Exam 2 review

75 questions

Photosynthesis Exam 2 review

quiz

Worksheet

•

University

Microbiological Culture and Testing

80 questions

Microbiological Culture and Testing

quiz

Worksheet

•

11th Grade - University

BIOLOGY PRACTICE EXAM

81 questions

BIOLOGY PRACTICE EXAM

quiz

Worksheet

•

University

Biology 10 FINAL 1

80 questions

Biology 10 FINAL 1

quiz

Worksheet

•

10th Grade - University

Anatomy and Physiology Cardiovascular System

75 questions

Anatomy and Physiology Cardiovascular System

quiz

Worksheet

•

University

Dhole

80 questions

Dhole

quiz

Worksheet

•

University - Professi...