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WorksheetsUrethral Cancer 30 (1)
Total questions: 30
Worksheet time: 15mins
Which histologic type is most common in female urethral cancer?
Adenocarcinoma
Small cell carcinoma
Squamous cell carcinoma
Transitional cell carcinoma
Sarcoma
The most common site of urethral carcinoma in men is:
Prostatic urethra
Penile urethra
Bulbomembranous urethra
Navicular fossa
Bladder neck
Risk factors for urethral cancer include all EXCEPT:
Chronic urethral stricture
Chronic catheterization
HPV infection
Circumcision
Urethritis
Which of the following statements about urethral cancer staging is TRUE?
There is a single TNM staging for both sexes
Lymph node involvement is not considered
Female urethral cancer staging is based on anterior vs. entire urethra involvement
T1 means muscle invasion
T4 is confined to urethral wall
The most common histology of prostatic urethral carcinoma is:
Squamous cell carcinoma
Adenocarcinoma
Transitional cell carcinoma
Small cell carcinoma
Sarcoma
Which imaging modality is best for local staging of urethral carcinoma?
KUB X-ray
Intravenous urography
PET-CT
MRI pelvis
Cystography
In men, which lymph nodes are primarily involved in anterior urethral cancers?
Inguinal lymph nodes
Pelvic lymph nodes
Para-aortic lymph nodes
Iliac lymph nodes
Presacral lymph nodes
What is the treatment of choice for localized distal urethral cancer in men?
Radical urethrectomy
Partial penectomy
Chemotherapy
Radiation therapy
Cystoprostatectomy
Which of the following is considered an early symptom of urethral cancer?
Hematuria
Renal colic
Nocturia
Urinary retention
Flank pain
The gold standard for tissue diagnosis in suspected urethral cancer is:
Fine needle aspiration
Biopsy via urethrocystoscopy
Urine cytology
Brush cytology
Core needle biopsy
Which gender has a worse overall prognosis in urethral cancer?
Female
Male
Equal
Only based on histology
Only based on treatment
Carcinoma of the female urethra most commonly arises in the:
Distal one-third
Middle one-third
Proximal one-third
Bladder neck
Paraurethral glands
HPV-related urethral cancers are usually of what histologic type?
Squamous cell carcinoma
Adenocarcinoma
Transitional cell carcinoma
Urothelial carcinoma
Sarcoma
Which of the following statements regarding urethral diverticulum and cancer is TRUE?
It has no association with malignancy
It is associated with adenocarcinoma
It only causes infection
It is never symptomatic
It occurs in males only
T3 stage in male urethral cancer indicates:
Subepithelial invasion
Corpus spongiosum invasion
No muscle invasion
Corpus cavernosum or anterior vagina invasion
Metastatic disease
A 65-year-old woman presents with urethral bleeding and a palpable urethral mass. The most appropriate next step is:
Antibiotics
Cystoscopy and biopsy
CT abdomen
Hormonal therapy
MRI brain
Which urethral cancer subtype has the worst prognosis?
Squamous cell carcinoma
Adenocarcinoma
Urothelial carcinoma
Melanoma
None
For muscle-invasive urethral carcinoma in females, the preferred definitive treatment is:
Radiation alone
Anterior pelvic exenteration
Chemotherapy
Laser ablation
Observation
In patients with advanced urethral cancer, which chemotherapy is commonly used?
Cisplatin-based combination
Methotrexate alone
Cyclophosphamide
BCG
Docetaxel
The most important prognostic factor in urethral carcinoma is:
Age
Gender
Tumor stage
Tumor location
Lymphocyte count
Which of the following histologic types has the worst prognosis in urethral cancer?
Transitional cell carcinoma
Adenocarcinoma
Squamous cell carcinoma
Clear cell carcinoma
Small cell carcinoma
The most common location of primary urethral cancer in men is:
Prostatic urethra
Bulbomembranous urethra
Penile urethra
Navicular fossa
External meatus
Which of the following is a risk factor for developing urethral cancer?
Ureteric stent
Chronic urethral stricture
Varicocele
Ureterocele
Overactive bladder
Which diagnostic tool is best for assessing urethral wall involvement?
CT urogram
MRI pelvis
PET scan
Retrograde urethrogram
X-ray KUB
Urethral diverticula are most commonly associated with which malignant histology?
Transitional cell carcinoma
Squamous cell carcinoma
Adenocarcinoma
Melanoma
Small cell carcinoma
Which of the following is TRUE regarding HPV-related urethral carcinoma?
It is typically adenocarcinoma
It is mostly squamous cell carcinoma
It usually arises from diverticula
It is more common in older men
It is treated only with chemotherapy
In female patients, urethral cancer most commonly arises from the:
Distal one-third
Proximal urethra
Bladder neck
Skene's glands
Paraurethral ducts
A man with cancer involving the penile urethra is most likely to have which lymph node basin affected first?
Inguinal lymph nodes
External iliac lymph nodes
Internal iliac lymph nodes
Common iliac lymph nodes
Presacral nodes
What is the most appropriate initial diagnostic step for a patient with suspected urethral cancer?
Urine cytology
Urethrocystoscopy with biopsy
PET scan
MRI pelvis
CT abdomen and pelvis
Which clinical finding most strongly suggests advanced urethral cancer?
Urethral bleeding
Palpable perineal mass
Urinary urgency
Dysuria
Microscopic hematuria
