WorksheetsChapter 25 Pharm Final Review
Total questions: 70
Worksheet time: 35mins
What is the definition of a parasite?
A developmental form of a host
A living organism that survives at the expense of another organism, called the host
A type of bacteria that infects the skin
A virus that causes respiratory infections
Which type of parasite mainly affects the digestive tract and other tissues?
Helminths
Ectoparasites
Protozoa
Bacteria
What are the symptoms of untreated giardiasis?
Fever and chills
Anorexia, nausea, malaise, weight loss, foul-smelling stools
Skin rashes and itching
Severe headaches and dizziness
What is a possible consequence of untreated Plasmodium falciparum malaria?
Skin irritation
Severe illness or death
Mild headaches
Temporary blindness
Which of the following is a symptom of amebiasis?
Skin rash
Nausea, vomiting, diarrhea, abdominal cramps, weakness
Joint pain
Blurred vision
What is the main symptom of pediculosis (lice infestation)?
Intense pruritus (itching)
Intestinal obstruction
Pulmonary symptoms
Vaginal burning
Which drug is primarily used to treat both intestinal and extraintestinal amebiasis?
Metronidazole
Chloroquine
Tetracycline
Doxycycline
What is the absorption rate of Metronidazole in the GI tract?
80%
60%
50%
90%
Which of the following can cause anemia by blood feeding from intestinal mucosa?
Hookworms
Pinworms
Fish tapeworms
Scabies
What is the half-life of Metronidazole?
6 to 8 hours
3 to 5 hours
10 to 12 hours
1 to 3 hours
What is the primary action of metronidazole on microorganisms?
It enhances cell membrane synthesis.
It diffuses across cell membranes causing cell death.
It inhibits protein synthesis.
It increases cell wall permeability.
Which of the following conditions is metronidazole NOT FDA-approved for prophylaxis?
Intestinal amebiasis
Amebic liver abscess
Trichomoniasis
Amebiasis prophylaxis
What is a significant warning associated with metronidazole and tinidazole?
They can cause severe allergic reactions.
They have produced carcinogenicity in rats.
They are ineffective against viral infections.
They cause severe liver damage.
Why should metronidazole be used cautiously in patients with abnormal kidney or hepatic function?
It may cause increased metabolism.
It can lead to drug accumulation.
It enhances liver enzyme activity.
It decreases kidney filtration rate.
Which adverse effect is NOT associated with metronidazole?
Headache
Dizziness
Increased appetite
Darkening of urine
What adverse effects may occur when alcohol or alcohol-containing medications are taken with metronidazole?
Increased appetite and energy
Tachycardia, flushing, tingling, nausea, and vomiting
Improved digestion and hydration
Enhanced absorption of nutrients
How should metronidazole be administered to improve absorption?
On an empty stomach
With food
With alcohol
With herbal supplements
What should be monitored to assess the therapeutic effects of metronidazole in intestinal amebiasis?
Increased appetite
Decreased abdominal pain and diarrhea
Enhanced energy levels
Improved skin condition
Which of the following is a common adverse effect of tinidazole?
Increased appetite
Bitter metallic taste and nausea
Enhanced energy levels
Improved skin condition
What is the function of nitazoxanide in treating parasitic infections?
Enhances the immune system
Inhibits growth of Cryptosporidium parvum and Giardia duodenalis
Increases nutrient absorption
Reduces inflammation
What is the prototype drug for antimalarials mentioned in the document?
Primaquine
Quinine
Chloroquine phosphate
Mefloquine
Which of the following is a pharmacokinetic property of chloroquine?
Rapidly absorbed in the GI tract
Excreted primarily by the lungs
Peak action in 5 to 7 hours
Not protein bound
Chloroquine is less effective against which resistant strain of malaria?
Plasmodium malariae
Plasmodium ovale
Plasmodium falciparum
Plasmodium vivax
What is one of the actions of chloroquine in treating malaria?
Enhances DNA polymerase activity
Inhibits DNA and RNA polymerase
Decreases internal pH within parasitic acid vesicles
Promotes prostaglandin effects
Which of the following is NOT a use of chloroquine?
Suppresses and prevents malaria
Treats acute malaria caused by Plasmodium vivax
Treats extrainestinal amebiasis
Treats acute malaria caused by Plasmodium ovale
Which of the following is true about the use of chloroquine during pregnancy?
It should not be used during pregnancy.
It increases the risk of adverse fetal effects.
Dosing is different for pregnant and nonpregnant adults.
Dosing is the same for pregnant and nonpregnant adults.
What are some adverse effects of chloroquine?
Increased appetite and weight gain
Visual disturbances and retinal damage
Improved focus and concentration
Enhanced muscle strength
Which condition is a contraindication for chloroquine use?
Hypertension
Diabetes
Porphyria
Asthma
What should patients taking chloroquine avoid to prevent decreased drug effectiveness?
Foods that alkalize urine
Foods that acidify urine
Foods high in sugar
Foods low in protein
How can patients improve adherence to chloroquine prophylaxis for malaria?
Taking it at different times each week
Using a calendar to take it on the same day each week
Taking it only when symptoms appear
Doubling the dose every other week
What is a recommended practice when taking chloroquine for malaria treatment?
Take the drug on an empty stomach.
Take the drug at different times each day.
Take the drug with food to reduce stomach upset.
Take the drug only when symptoms appear.
Which drug may increase the plasma concentration of chloroquine?
Magnesium trisilicate
Vitamin C
Cimetidine
Quinine
What should be monitored to assess the therapeutic effects of chloroquine in malaria treatment?
Increase in appetite
Reduction in malaria symptoms
Increase in energy levels
Improvement in sleep patterns
What is the first-line therapy to treat severe malaria according to the analysis by Daly, Minuti, and Khan?
Chloroquine
Quinine
Intravenous artesunate
Vitamin C
What condition should healthcare providers screen for before prescribing primaquine?
Vitamin C deficiency
G-6-DP deficiency
Magnesium deficiency
Iron deficiency
What is the primary use of Artemisinin-based Combination Therapies (ACTs)?
To treat bacterial infections
To prevent drug resistance in uncomplicated malaria
To cure viral infections
To relieve pain
Which of the following is the only ACT approved by WHO in the US?
Hydroxychloroquine
Atovaquone
Artemether/lumefantrine (Coartem)
Mefloquine
What is a notable side effect of Atovaquone–Proguanil (Malarone)?
Increased appetite
Vomiting and diarrhea
Hair loss
Skin rash
Which medication is a derivative of chloroquine with fewer side effects?
Mefloquine
Hydroxychloroquine
Primaquine
Artemether
What is the BLACK BOX WARNING associated with Mefloquine?
Risk of severe allergic reactions
Possible persistent neuropsychiatric effects
Liver damage
Heart failure
What is the primary function of anthelmintics?
To treat bacterial infections
To kill or expel parasitic worms
To reduce inflammation
To lower blood pressure
What is the prototype drug mentioned for treating worm infestations?
Albendazole
Mebendazole
Ivermectin
Praziquantel
How is Mebendazole primarily excreted from the body?
Through urine
Through sweat
Through feces
Through saliva
Which of the following infections is NOT treated by Mebendazole?
Pinworm
Whipworm
Malaria
Roundworm
What is a significant adverse effect of Mebendazole?
Hypertension
Dizziness
Weight gain
Insomnia
Why should caution be advised when using Mebendazole during lactation?
It causes high blood pressure
It passes into breast milk
It increases appetite
It causes dehydration
Which condition is a contraindication for the use of mebendazole?
Liver enzyme increases
Hypersensitivity
Anemia
Neutropenia
What should be done to improve the absorption of mebendazole?
Take it on an empty stomach
Take it with food
Avoid taking it with liquids
Take it with dairy products
Which drug increases the effects of mebendazole?
Aspirin
Metronidazole
Ibuprofen
Acetaminophen
What should be monitored to assess for adverse effects of mebendazole?
Blood pressure
Liver enzymes (AST, ALT)
Heart rate
Blood sugar levels
How long after treatment should stool samples be obtained to assess for therapeutic effects?
1 week
2 weeks
3 weeks
4 weeks
Which drug is recommended to be taken with a high-fat meal to improve absorption for the treatment of ascariasis?
Triclabendazole
Albendazole
Ivermectin
Aminoquinolines
What is the primary action of permethrin in treating lice or scabies?
Inhibiting protein synthesis in parasites
Blocking sodium ion channels in parasites' nerve cells
Increasing calcium ion concentration in parasites
Disrupting DNA replication in parasites
Which of the following is true about the use of permethrin during pregnancy?
It is not recommended by the CDC.
It is recommended as a treatment of choice for pubic lice and scabies.
It should be avoided due to high systemic absorption.
It is ineffective against lice epidemics.
What is the effect of carbamazepine on mebendazole serum concentration?
Increases concentration
Decreases concentration
No effect
Doubles concentration
What is a contraindication for using permethrin?
Hypersensitivity to chrysanthemums
Age over 2 months
Presence of lice
Scalp numbness
What should be done after applying permethrin for head lice treatment?
Leave on for 10 minutes, then rinse thoroughly with water
Leave on for 8-14 hours, then wash off
Apply only to the face
Reapply immediately if itching occurs
What precaution should be taken when administering permethrin for head lice or scabies?
Wear gloves to prevent spreading the infection
Apply to the face and eyes
Use only on children under 2 months
Leave on for 24 hours
How should cream be applied for scabies treatment?
Apply from head to toe and leave on for 8-14 hours
Apply only to the scalp and leave on for 10 minutes
Apply behind ears and at the base of the neck
Apply only to affected areas and wash off immediately
What is a nursing implication when using permethrin?
Inspect skin areas for signs of inflammation
Apply cream only to the face
Leave cream on for 24 hours
Avoid washing the treated area
What is a second-line treatment for scabies and lice?
Malathion
Pyrethrin
Spinosad
Black Box Warning
What is a significant risk associated with the use of certain antiparasitic drugs, even with correct use?
Skin irritation
Neurologic toxicities
Allergic reactions
Gastrointestinal issues
Which antiparasitic drug is over-the-counter for pediculosis and may require a second application in 7 to 9 days?
Malathion
Pyrethrin
Spinosad
Black Box Warning
What is a general consideration for preventing parasitic infections when traveling to tropical areas?
Avoiding dairy products
Consulting local health departments
Using sunscreen
Drinking bottled water only
Which antiparasitic drug is pediculicidal and ovicidal for head lice and causes paralysis by exciting the parasite CNS?
Malathion
Pyrethrin
Spinosad
Black Box Warning
What should be avoided while taking metronidazole or tinidazole and for 3 days after?
Dairy products
Alcohol
Caffeine
Spicy foods
What is recommended for malaria prophylaxis with chloroquine?
Take medication daily
Take medication at the same time weekly
Take medication only when symptoms appear
Take medication every other day
What should be done if diarrhea occurs while taking medication?
Fast for 24 hours
Eat large meals
Eat small frequent meals and stay well hydrated
Avoid all liquids
How often should bed linens be washed in the case of a pinworm infection?
Weekly
Every other day
Daily
Monthly
What should be done after applying permethrin cream, lotion, or rinse?
Avoid washing the area for a week
Report any stinging, tingling, numbness, rash, or itching to your prescriber
Cover the area with a bandage
Expose the area to sunlight
