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MEDL 201: Innate Immunity

Total questions: 71

Worksheet time: 37mins

Name
Class
Date
1.

Fill in the blank: The external defense system includes physical, chemical, and ________ barriers.

a)

biological

b)

mechanical

c)

thermal

d)

magnetic

2.

Which of the following is NOT a component of the internal defense system?

a)

Pattern-recognition receptors

b)

Acute-phase reactants

c)

Physical barriers

d)

Inflammation

3.

Fill in the blank: ________ is a process in which a cell eats another cell.

a)

Phagocytosis

b)

Osmosis

c)

Photosynthesis

d)

Transpiration

4.

Fill in the blank: Innate lymphoid cells are a component of the ________ defense system.

a)

internal

b)

external

c)

adaptive

d)

chemical

5.

Fill in the blank: The innate immune system consists of defenses that act immediately when a host is attacked by a ________.

a)

pathogen

b)

vitamin

c)

hormone

d)

enzyme

6.

Which of the following best describes the innate immune system?

a)

Specific

b)

Nonspecific

c)

Adaptive

d)

Delayed response

7.

Which of the following is a function of the internal defense system in the innate immune system?

a)

Producing antibodies

b)

Cellular responses that recognize specific molecular components of pathogens

c)

Memory cell formation

d)

Hormone production

8.

What are the three types of barriers that prevent infectious agents from entering the body according to the External Defense System?

a)

Physical, chemical, and biological barriers

b)

Mechanical, enzymatic, and hormonal barriers

c)

Thermal, electrical, and magnetic barriers

d)

Genetic, metabolic, and sensory barriers

9.
Question Image

Match the following body parts or substances with their defense mechanisms:

a)

Lysozyme

1.

Lacrimal glands/Salivary glands

b)

Mucus and Cilia

2.

Airways

c)

Keratinocytes, lactic acid, fatty acids

3.

Skin

d)

Gastric acid

4.

Stomach

10.

What is the main function of the skin in the external defense system?

a)

Absorb nutrients

b)

Physical barrier to pathogen entry

c)

Produce hormones

d)

Store fat

11.

Which layer of the skin is made up of tightly packed epithelial cells coated in keratin?

a)

Epidermis

b)

Dermis

c)

Hypodermis

d)

Subcutaneous layer

12.

Which of the following is NOT found in the dermis?

a)

A) Blood vessels

b)

B) Hair follicles

c)

C) Sweat glands

d)

D) Keratin-coated epithelial cells

13.

Lactic acid and fatty acids maintain the skin at a pH of approximately _____?

a)

5.6

b)

7.0

c)

4.0

d)

6.5

14.

Proteins with antibacterial effects in the skin include ________.

a)

psoriasin

b)

melanin

c)

collagen

d)

elastin

15.

Mucous membranes line which tracts in the body?

a)

Respiratory, digestive, and genitourinary tracts

b)

Circulatory and nervous tracts

c)

Muscular and skeletal tracts

d)

Endocrine and lymphatic tracts

16.

Mucous secretions contain surfactants that block bacteria from adhering to ______ cells.

a)

epithelial

b)

muscle

c)

nerve

d)

connective

17.

Fill in the blank: The stomach's hydrochloric acid keeps the pH as low as ____, prohibiting microorganism growth.

a)

1

b)

4

c)

7

d)

9

18.

Which enzyme in tears and saliva attacks cell walls of gram-positive bacteria?

a)

Amylase

b)

Lysozyme

c)

Pepsin

d)

Lipase

19.

What keeps the vagina pH at approximately 5?

a)

Hydrochloric acid

b)

Lactic acid

c)

Lysozyme

d)

Bile

20.

Normal microbiota in the body play a role in protecting against the colonization of ________.

a)

pathogens

b)

vitamins

c)

enzymes

d)

antigens

21.

Which of the following is a component of the Internal Defense System?

a)

Pattern-recognition receptors

b)

Red blood cells

c)

Platelets

d)

Antibodies

22.

Pattern Recognition Receptors (PRRs) recognize molecules unique to infectious organisms called _________

a)

pathogen-associated molecular patterns (PAMPs)

b)

major histocompatibility complexes (MHCs)

c)

antigen-presenting cells (APCs)

d)

complement proteins

23.

What happens when Pattern Recognition Receptors (PRRs) bind to a pathogen?

a)

They activate phagocytic cells.

b)

They produce antibodies directly.

c)

They destroy the pathogen immediately.

d)

They cause the pathogen to mutate.

24.

Which of the following are examples of Pattern Recognition Receptors (PRRs)?

a)

TLRs

b)

CLRs

c)

RLRs

d)

NLRs

e)

All of the above

25.

How many types of Toll-Like Receptors (TLRs) are found in humans?

a)

5

b)

7

c)

10

d)

12

26.

Where are some Toll-Like Receptors (TLRs) located in human cells?

a)

Only on cell surfaces

b)

Only in the nucleus

c)

Some on cell surfaces and some in cytoplasm

d)

Only in mitochondria

27.

Toll-Like Receptors (TLRs) are glycoproteins that bind to microbial substances, activating ______ and chemokine production and other processes.

a)

cytokine

b)

lipid

c)

glucose

d)

antibody

28.

Phagocytosis is enhanced and adaptive immunity is triggered by Toll-Like Receptors (TLRs), destroying pathogens before disease sets in.

a)

True

b)

False

29.

According to the diagram, which TLR is associated with recognizing viral dsRNA?

a)

TLR 3

b)

TLR 4

c)

TLR 5

d)

TLR 9

30.

According to the diagram, TLR 4 is found in which cellular location?

a)

Endosomal membrane

b)

Plasma membrane

c)

Cytoplasm

d)

Nucleus

31.

Fill in the blank: C-type lectin receptors (CLRs) bind to ______ and β-glucans in fungal cell walls to activate cytokine and chemokine.

a)

mannan

b)

lipopolysaccharide

c)

peptidoglycan

d)

chitin

32.

Which type of receptor recognizes RNA from RNA viruses and induces production of inflammatory cytokines/type I interferons?

a)

C-type lectin receptors (CLRs)

b)

Retinoic acid-inducible gene-I-like receptors (RLRs)

c)

Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs)

33.

Fill in the blank: Nucleotide-binding oligomerization domain (____)-like receptors (NLRs).

a)

NOD

b)

TIR

c)

LRR

d)

CARD

34.

Acute-phase reactants are ______ normally found in serum.

a)

soluble factors

b)

insoluble proteins

c)

cellular enzymes

d)

membrane receptors

35.

Acute-phase reactants increase rapidly in response to which of the following?

a)

Infection

b)

Injury

c)

Tissue trauma

d)

All of the above

36.

Acute-phase reactants facilitate contact between microbes and phagocytic cells by way of what process.

a)

opsonization

b)

selection

c)

normalization

d)

recognition

37.

What do acute-phase reactants limit during phagocytosis?

a)

Host tissue destruction caused by proteolytic enzyme release

b)

Bacterial replication within phagosomes

c)

Antibody production by B cells

d)

Oxygen consumption by neutrophils

38.

During inflammation, acute-phase reactants bind to, and recycle, important ______ and minerals.

a)

proteins

b)

carbohydrates

c)

lipids

d)

vitamins

39.

What is the response time (in hours) for C-reactive protein?

a)

24

b)

4-6

c)

48-72

d)

200-400

40.

What is the normal concentration (mg/dL) of Serum amyloid A?

a)

0.5

b)

5

c)

200-400

d)

40-290

41.

Alpha1-antitrypsin has a normal concentration of ______ mg/dL.

a)

200-400

b)

20-40

c)

400-600

d)

1000-1200

42.

Which protein is responsible for clot formation?

a)

C-reactive protein

b)

Fibrinogen

c)

Haptoglobin

d)

Ceruloplasmin

43.

Haptoglobin binds _______.

a)

hemoglobin

b)

albumin

c)

bilirubin

d)

fibrinogen

44.

What is the increase factor for Ceruloplasmin during the acute-phase response?

a)

1,000X

b)

2-5X

c)

2-10X

d)

2X

45.

Complement C3 is involved in which functions?

a)

Opsonization, complement activation

b)

Activates monocytes and macrophages

c)

Opsonization, lysis

d)

Binds copper and oxidizes iron

46.

What is the body's overall reaction to injury or invasion by an infectious agent called?

a)

Inflammation

b)

Digestion

c)

Respiration

d)

Osmosis

47.

Which of the following is a cardinal sign of inflammation?

a)

Redness (erythema)

b)

Numbness

c)

Itching

d)

Bruising

48.

Which of the following is a cardinal sign of inflammation?

a)

Swelling (edema)

b)

Bleeding

c)

Rash

d)

Stiffness

49.

Which of the following is a cardinal sign of inflammation?

a)

Heat

b)

Cold

c)

Tingling

d)

Weakness

50.

Major Events Involved in Acute Inflammation: Fill in the blank: Resident macrophages and mast cells at the site of infection release _______ that cause vasodilation and induce selectins.

a)

chemokines

b)

antibodies

c)

lymphocytes

d)

platelets

51.

Fill in the blank: Integrins enable the leukocytes to crawl between endothelial cells, a process called _______.

a)

diapedesis

b)

phagocytosis

c)

apoptosis

d)

chemotaxis

52.

Leukocytes then follow the chemokine concentration gradient to the site of infection, a process called _______.

a)

chemotaxis

b)

phagocytosis

c)

apoptosis

d)

osmosis

53.

Which of the following is a type of phagocytic cell attracted to the site of inflammation?

a)

Neutrophils

b)

Erythrocytes

c)

Platelets

d)

Basophils

54.

Which of the following is NOT a phagocytic cell attracted to the site of inflammation?

a)

Monocytes

b)

Macrophages

c)

Dendritic cells

d)

Lymphocytes

55.

Fill in the blank: The process of phagocytosis is enhanced by opsonins like _____

a)

CRP

b)

Albumin

c)

Fibrinogen

d)

Transferrin

56.

Which step in the process of phagocytosis involves the outflowing of cytoplasm to surround the microorganism?

a)

Adherence

b)

Engulfment

c)

Digestion

d)

Excretion

57.
Question Image

Match the step number with the correct description from the process of phagocytosis:

a)

Physical contact between the phagocytic cell and the microorganism

1.

Adherence

b)

Outflowing of cytoplasm to surround the microorganism

2.

Engulfment

c)

Microorganism is completely surrounded by a part of the cell membrane

3.

Formation of phagosome

d)

Lysosomal granules contact and fuse with the phagosome

4.

Granule contact

e)

Contents of the lysosome are emptied into the phagosome

5.

Formation of the phagolysosome

58.

What is the role of the HMP shunt in the oxidative burst during the killing of pathogens?

a)

Converts NADP to NADPH

b)

Converts O2 to H2O2

c)

Activates lytic enzymes

d)

Alters pH of the cell

59.

In the O2 independent pathway, what change leads to the activation of lytic enzymes such as defensins?

a)

Increase in NADPH

b)

Alteration of cell pH

c)

Conversion of O2 to H2O2

d)

Production of OH-

60.

Fill in the blank: During the oxidative burst, O2 is converted to O2- ; O2- to _______ and OH-.

a)

O2-

b)

H2O2

c)

CO2

d)

H2O

61.

Which enzyme is involved in the conversion of H2O2 and Cl- to OCl- and H2O in the phagolysosome?

a)

MPO (Myeloperoxidase)

b)

Catalase

c)

Superoxide dismutase

d)

Glutathione peroxidase

62.

Natural Killer (NK) cells are the first line of defense against cells that are ______ infected, cells infected with other intracellular pathogens, and tumor cells.

a)

virally

b)

bacterially

c)

mechanically

d)

chemically

63.

Natural Killer (NK) cells recognize altered structures on damaged cells and can eliminate them without prior ______.

a)

exposure

b)

activation

c)

division

d)

migration

64.

NK activity is enhanced by certain ______.

a)

cytokines

b)

antibodies

c)

hormones

d)

enzymes

65.

NK cells produce other cytokines that recruit T cells and aid in development of ______ and macrophages.

a)

granulocytes

b)

erythrocytes

c)

neurons

d)

hepatocytes

66.

Based on the diagram, what is the result when inhibition occurs between an NK cell and a target cell?

a)

No killing of the target cell occurs.

b)

The target cell is immediately destroyed.

c)

The NK cell releases cytokines to activate the target cell.

d)

The target cell undergoes apoptosis due to NK cell action.

67.

NK cells can induce apoptosis in which of the following types of target cells?

a)

Bacterial cells

b)

Virally infected cells

c)

Antibody-coated target cells

d)

Both Bacterial cells & Virally infected cells

68.
Mary feels sick for a week and decides to go to the doctor. The doctor tells her that she has a viral infection and does not prescribe antibiotics to treat her illness. Within a couple of days Mary is feeling better. Which statement best describes Mary's path to recovery?
a)
Mary was already feeling better and didn't need to go to the doctor's office.
b)
Antibiotics produced by Mary's body stimulated her immune system to produce enough antibodies against the virus and destroy the viral infection.
c)
The nonspecific immune response destroyed the virus through inflammation two weeks after Mary went to the doctor's office
d)
The specific immune response produced antibodies that rid her body of the viral infection after it learned the properties of the viral molecule.
69.
All foreign materials that cause a response from the immune system are called _____________________.
a)
Antigens
b)
Active Immunity
c)
Antibodies
d)
Antibiotics
70.
All of these are part of the innate immune response except: 
a)
B cells
b)
mast cells
c)
natural killer cells
d)
macrophages
71.

What is the main purpose of a vaccine?

a)

To cure diseases

b)

To diagnose diseases

c)

To prevent diseases

d)

To treat symptoms