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WorksheetsEndocrine
Total questions: 155
Worksheet time: 5hrs 10mins
Which statement best describes the endocrine system?
Uses electrical impulses to control short-term responses
Uses chemical messengers transported in blood to regulate distant targets
Only controls voluntary muscle activity
Functions independently of the nervous system
The endocrine system is primarily responsible for:
Rapid transmission of nerve signals
Maintaining homeostasis through hormones
Muscle contraction and reflex arcs
Digestion only
Which communication method involves signaling through gap junctions?
Paracrine signaling
Synaptic transmission
Direct cell-to-cell communication
Endocrine signaling
(Select all that apply) Which of the following are examples of paracrine signaling?
Nitric oxide causing vasodilation
Neurotransmitter release into a synapse
Histamine released from mast cell
Insulin entering the bloodstream
Endocrine glands differ from exocrine glands because endocrine glands:
Release hormones through ducts
Have no ducts and secrete hormones into the bloodstream
Secrete enzymes directly into organs
Function only in digestion
Which of the following hormones are not hydrophilic?
Peptide hormones
Monoamines
Steroid hormones
Protein hormones
A hormone that acts on the same cell that secreted it is called:
Endocrine
Paracrine
Autocrine
Exocrine
The endocrine system differs from the nervous system in that endocrine responses:
Are faster
Are slower but longer lasting
Use electrical impulses
Affect single target organs only
Which hormones are derived from cholesterol?
Steroid hormones
Peptide hormones
Amine hormones
Glycoprotein hormones
Peptide hormones are generally:
Lipid-soluble and bind inside the cell
Water-soluble and bind to surface receptors
Stored in adipose tissue
Transported by albumin only
(Select all that apply) Which of the following are examples of amine (monoamine) hormones?
Norepinephrine
Epinephrine
Dopamine
Cortisol
Which of the following best defines a hormone?
A neurotransmitter released across a synapse
A chemical messenger released into the bloodstream
A digestive enzyme secreted into the stomach
A local paracrine molecule
Steroid hormones bind to receptors located:
On the plasma membrane
In the cytoplasm or nucleus
On ribosomes
In lysosomes
Hydrophilic hormones usually activate:
Direct gene transcription
Second messenger systems
Nuclear DNA binding
Enzyme inhibition
The secondary messenger cAMP is most directly activated by:
Protein kinases
Adenylyl cyclase
G proteins
ATP synthase
Which best describes enzyme amplification?
One hormone activates many enzymes, producing a large effect
Hormones are broken down quickly
Enzymes deactivate hormones
Hormone concentration equals response strength
Hormone signals are terminated primarily by:
Renal or hepatic degradation
Storage in vesicles
Neural inhibition only
Dilution in plasma
The half-life of a hormone refers to:
The time for full activation
The time to reduce its concentration by 50 %
Its rate of synthesis
The time it binds receptors
Down-regulation of receptors results in:
Increased cell sensitivity
Decreased cell sensitivity
Hormone overproduction
Enhanced enzyme amplification
(Select all that apply) Examples of synergistic hormone effects include:
Epinephrine and glucagon increasing blood glucose
Estrogen and progesterone regulating uterine lining
Calcitonin and parathyroid hormone acting together
Insulin and glucagon acting oppositely
Permissive hormone effects occur when:
Two hormones oppose each other
One hormone enhances the effect of another
Hormones have identical targets
Both hormones inhibit receptor binding
Antagonistic effects are demonstrated by:
Cortisol and growth hormone
Insulin and glucagon
Epinephrine and norepinephrine
LH and FSH
Which hormone is transported without a binding protein in plasma?
Thyroxine
Aldosterone
Cortisol
Estradiol
(Select all that apply) Hormones that bind to transport proteins in blood include:
Cortisol
Thyroxine
Testosterone
Epinephrine
The general characteristics of endocrine signaling include:
Rapid and short-term effects
Slow onset and prolonged effects
Localized and transient actions
Electrical impulse conduction
A single hormone can influence many different tissues because:
It binds non-specifically
Receptors for that hormone are expressed in many tissues
It mutates frequently
It is electrically conductive
Which best defines the metabolic clearance rate (MCR)?
The rate of hormone synthesis
The rate of hormone removal from blood
The diffusion rate into tissues
The enzyme activation rate
(Select all that apply) Which of these can act as both hormones and neurotransmitters?
Norepinephrine
Dopamine
ADH
Aldosterone
Endocrine cells release their products:
Through ducts to epithelial surfaces
Into extracellular fluid and blood
Only during neural stimulation
Into cerebrospinal fluid
Endocrine glands typically have:
Sparse blood supply
Dense capillary networks
No vascularization
Duct openings
Which class of hormones is derived from amino acids?
Steroid
Peptide
Amine
Lipid
Hydrophobic hormones must bind transport proteins mainly because:
They are degraded by plasma enzymes
They are insoluble in water
They lack receptors
They act too rapidly otherwise
A bound hormone is one that:
Is stored in vesicles
Is attached to a transport protein
Has bound to its receptor
Is degraded
The specificity of hormone action depends on:
Hormone concentration only
Target cell receptors
Electrical charge
Organ location
(Select all that apply) Hydrophobic hormones include:
Cortisol
Aldosterone
Thyroxine (T₄)
Epinephrine
Up-regulation refers to:
Loss of receptors
Increased receptor number on target cells
Reduced hormone affinity
Hormone degradation
The endocrine system regulates which of the following?
Muscle contraction only
Growth, metabolism, and reproduction
Reflex arcs
Neuron firing
(Select all that apply) Common second messenger systems include:
cAMP
IP₃
DAG
ATP synthase
The most common mechanism for regulating hormone secretion is:
Positive feedback
Negative feedback
Feed-forward activation
Osmotic regulation
In a negative feedback loop controlling thyroid hormone levels, elevated T₃/T₄ will:
Stimulate the hypothalamus
Inhibit TRH and TSH secretion
Activate the pituitary
Promote more thyroglobulin synthesis
The hypothalamus is anatomically located:
In the cerebral cortex
Forming the floor of the third ventricle
Within the cerebellum
Above the corpus callosum
The hypothalamus primarily controls the endocrine system through its influence on the:
Thyroid gland
Adrenal medulla
Pituitary gland
Pineal gland
The stalk connecting the pituitary gland to the hypothalamus is called the:
Sella turcica
Infundibulum
Median eminence
Hypophyseal portal vein
(Select all that apply) The pituitary gland is composed of:
Adenohypophysis
Neurohypophysis
Intermediate lobe/rudimentary
Medullary lobe
The anterior pituitary develops embryologically from:
An outgrowth of the pharynx (Rathke’s pouch)
The diencephalon
Neural ectoderm of the brain
The notochord
The posterior pituitary is derived from:
The hypothalamic neural tissue
Oral ectoderm
Mesoderm
Endoderm
The posterior pituitary stores and releases which two hormones?
FSH and LH
GH and PRL
ADH and oxytocin
TSH and ACTH
The hormone that causes uterine contractions and milk ejection is:
Prolactin
Oxytocin
ADH
LH
ADH acts primarily on the:
Liver
Kidneys
Heart
Pancreas
The main effect of ADH is to:
Increase urine output
Promote water retention
Lower blood pressure
Increase sodium loss
(Select all that apply) Tropic hormones from the anterior pituitary include:
FSH
GH
ACTH
LH
Which anterior pituitary hormone stimulates milk production after childbirth?
LH
Prolactin
Oxytocin
ACTH
Growth hormone stimulates the liver to release:
IGF-1 and IGF-2
T₃ and T₄
Cortisol
Aldosterone
Which anterior pituitary hormone triggers ovulation?
FSH
LH
ACTH
TSH
Follicle-stimulating hormone (FSH) in males acts on:
Interstitial (Leydig) cells
Sertoli (sustentacular) cells
The prostate
Adrenal cortex
The target organ of thyroid-stimulating hormone (TSH) is the:
Hypothalamus
Thyroid gland
Adrenal cortex
Parathyroid gland
ACTH primarily stimulates the:
Adrenal cortex
Adrenal medulla
Thyroid
Pancreas
Excess secretion of GH before epiphyseal plate closure results in:
Dwarfism
Gigantism
Acromegaly
Cretinism
After epiphyseal closure, GH hypersecretion causes:
Gigantism
Acromegaly
Osteoporosis
Pituitary dwarfism
Which hormone acts to increase the metabolic rate in nearly all tissues?
GH
Thyroid hormone (T₃/T₄)
Cortisol
Epinephrine
(Select all that apply) Hypothalamic releasing hormones include:
TRH
CRH
GnRH
Somatostatin
The hypothalamo-hypophyseal portal system connects the:
Posterior pituitary to thyroid
Adrenal medulla to cortex
Pineal gland to hypothalamus
Hypothalamus to anterior pituitary
Neurosecretory cells send their axons through which tract to the posterior pituitary?
Corticospinal tract
Hypothalamo-hypophyseal tract
Optic tract
Reticulospinal tract
In the milk-ejection reflex, the sensory signal from a suckling infant ultimately causes release of:
Prolactin
Oxytocin
GH
ACTH
The hypothalamus controls the anterior pituitary primarily via:
Neural impulses
Direct axonal synapses
Electrical gap junctions
Releasing and inhibiting hormones
Which feedback mechanism regulates most pituitary-target hormone systems?
Positive feedback
Feed-forward activation
Negative feedback
Autonomic feedback
The hormone that stimulates adrenal cortex cortisol release is:
ACTH
TSH
GH
CRH
Low ADH secretion causes:
Diabetes mellitus
Diabetes insipidus
Cushing disease
Addison disease
The pituitary sits in a bony depression of the sphenoid bone called the:Foramen ovale
Foramen ovale
Foramen ovale
Sella turcica
Cribriform plate
(Select all that apply) Direct effects of growth hormone include:
Increased lipid breakdown
Increased water reabsorption by kidneys
Decreased glucose utilization
Increased protein synthesis
Which factor most strongly increases GH secretion?
High blood glucose
Chronic stress
Deep sleep
Low protein intake
Prolonged stress causes elevated levels of which anterior pituitary hormone?
TSH
ACTH
LH
PRL
Which of the following is a non-tropic hormone of the anterior pituitary?
ACTH
TSH
LH
GH
Excess prolactin in males may result in:
Decreased LH sensitivity
Increased testosterone
Hyperthyroidism
Elevated GH
(Select all that apply) The anterior pituitary secretes:
ADH
ACTH
PRL
GH
Which hypothalamic hormone inhibits GH and TSH release?
CRH
TRH
GnRH
Somatostatin
The hypophyseal portal veins carry hormones:
From anterior pituitary to hypothalamus
From hypothalamus to anterior pituitary
From posterior pituitary to thyroid
From adrenal gland to hypothalamus
What is the principal cell type of the posterior pituitary?
Chromophobes
Somatotropes
Pituicytes
Thyrotropes
The small mass of tissue connecting the hypothalamus to the pituitary is called the:
Paraventricular nucleus
Pineal recess
Tectum
Median eminence
The hypothalamic nuclei that produce ADH and oxytocin are the:
Arcuate and ventromedial nuclei
Mammillary nuclei
Supraoptic and paraventricular nuclei
Preoptic and lateral nuclei
The thyroid gland is located:
Behind the sternum
Around the trachea just below the larynx
Above the pituitary
Adjacent to the kidneys
The structural and functional units of the thyroid are called:
Follicles
Lobules
Acini
Cilia
The hormones produced by follicular cells of the thyroid are:
Calcitonin
ACTH and TSH
Aldosterone and Cortisol
T₃ (triiodothyronine) and T₄ (thyroxine)
The parafollicular (C) cells of the thyroid secrete:
T₃ and T₄
Calcitonin
Parathyroid hormone
Cortisol
Thyroid hormone synthesis requires which mineral?
Sodium
Iodine
Iron
Zinc
(Select all that apply) Thyroid hormones increase:
Mitochondrial enzyme activity
Blood calcium levels
Basal metabolic rate
Heat production
The hormone that raises blood Ca²⁺ levels is:
Calcitonin
Oxytocin
Parathyroid hormone (PTH)
Aldosterone
The parathyroid glands are found:
Inside the thyroid follicles
On the adrenal cortex
In the pancreas
Embedded on the posterior surface of the thyroid
Parathyroid hormone (PTH) stimulates:
Decreased bone resorption
Increased bone resorption
Decreased Ca²⁺ absorption in the gut
Decreased kidney Ca²⁺ reabsorption
Hypocalcemia would trigger release of:
Calcitonin
Aldosterone
PTH
Insulin
(Select all that apply) The adrenal glands consist of:
An outer cortex
An inner medulla
A fibrous capsule
A parathyroid zone
The adrenal cortex produces:
Catecholamines
Corticosteroids
Neurotransmitters
Peptide hormones
The adrenal medulla acts as part of the:
Parasympathetic division
Somatic system
Sympathetic nervous system
Endocardium
The zona glomerulosa of the adrenal cortex secretes:
Glucocorticoids
Catecholamines
Sex steroids
Mineralocorticoids
The zona fasciculata primarily produces:
Cortisol
Aldosterone
Testosterone
Epinephrine
The zona reticularis secretes:
Estrogen and progesterone
Androgens (e.g., DHEA)
Cortisol
Aldosterone
Long-term use of glucocorticoids can cause:
Increased immune function
Hypercalcemia
Hypoglycemia
Immune suppression
The adrenal medulla releases:
Cortisol and aldosterone
Epinephrine and norepinephrine
Estrogen and testosterone
PTH and calcitonin
Epinephrine promotes which metabolic effect?
Fat storage
Glycogen synthesis
Glycogen synthesis
Protein anabolism
(Select all that apply) Short-term stress responses include:
↑ Heart rate
↑ Blood pressure
↑ Blood glucose
↓ Respiratory rate
Aldosterone acts primarily on which organ?
Heart
Kidney
Liver
Thyroid
The renin–angiotensin–aldosterone system (RAAS) is activated by:
High blood pressure
Hyperkalemia only
Low blood pressure or Na⁺
Increased blood volume
Renin converts ________ to ________.
Angiotensin I → Angiotensin II
Angiotensin II → Aldosterone
Cortisol → Cortisone
Angiotensinogen → Angiotensin I
The enzyme converting angiotensin I to angiotensin II is:
Renin
Angiotensin-converting enzyme (ACE)
Aldosterone synthase
Pepsin
Angiotensin II causes:
Vasodilation
Vasoconstriction
Decreased ADH
Decreased thirst
(Select all that apply) Aldosterone increases:
Ca²⁺ secretion
Na⁺ reabsorption
K⁺ excretion
Water retention
The alarm reaction of the general adaptation syndrome (GAS)** involves elevation of:**
Cortisol and ACTH
Insulin and glucagon
Epinephrine and norepinephrine
GH and IGF
The resistance stage of GAS** is dominated by:**
Catecholamines
Cortisol
Insulin
Oxytocin
The exhaustion stage of GAS is characterized by:
Fat reserve depletion
Enhanced immunity
Elevated glucose homeostasis
Increased strength
Chronic cortisol excess may produce:
Addison disease
Hypoglycemia
Gigantism
Cushing syndrome
Adrenal insufficiency with low cortisol and aldosterone is known as:
Cushing syndrome
Acromegaly
Addison disease
Diabetes insipidus
(Select all that apply) Cortisol promotes:
Gluconeogenesis
Anti-inflammatory effects
Increased protein synthesis
Fat and protein catabolism
Excess aldosterone secretion causes:
Hyponatremia
Hypernatremia and hypokalemia
Acidosis
Hypotension
The hormone that directly stimulates thirst during RAAS activation is:
Cortisol
Angiotensin II
ADH
ACTH
ACE inhibitors are used clinically to:
Increase renin secretion
Stimulate aldosterone release
Increase BP
Lower BP by blocking angiotensin II formation
The pancreas has both ________ and ________ functions.
Nervous; endocrine
Endocrine; exocrine
Somatic; sympathetic
Renal; digestive
The endocrine portions of the pancreas are called:
Canaliculi
Ducts of Santorini
Acini
Islets of Langerhans
The β (beta) cells of the pancreas secrete:
Glucagon
Somatostatin
Insulin
Cortisol
The α (alpha) cells of the pancreas secrete:
Insulin
Glucagon
Amylase
Somatostatin
Somatostatin from δ (delta) cells acts to:
Increase glucagon secretion
Inhibit both insulin and glucagon secretion
Stimulate growth hormone release
Promote digestion
(Select all that apply) Insulin functions to:
Raise blood glucose
Promote glucose uptake by cells
Promote protein and fat storage
Stimulate glycogen synthesis
Glucagon’s primary target organ is the:
Liver
Stomach
Heart
Brain
Insulin secretion increases in response to:
Fasting
Low blood amino acids
Elevated blood glucose
Stress hormones
Low blood glucose triggers secretion of:
ADH
Insulin
Glucagon
Thyroxine
(Select all that apply) Prolonged diabetes mellitus results in:
Polyuria
Polydipsia
Polyphagia
Hypocalcemia
Type 1 diabetes mellitus is due to:
Insulin receptor defects
Autoimmune destruction of beta cells
Overproduction of glucagon
Dietary sugar excess
Type 2 diabetes mellitus is primarily caused by:
Insulin resistance
Viral infection
Autoimmunity
Lack of glucagon
In diabetes mellitus, glycosuria occurs because:
Kidneys over-secrete glucose
Insulin suppresses reabsorption
Renal glucose transporters are saturated
Glucagon binds to nephrons
The primary function of estrogen in females is to:
Stimulate milk ejection
Promote development of reproductive organs and secondary sex characteristics
Increase glycogen breakdown
Promote bone resorption
The corpus luteum secretes:
Estrogen and progesterone
FSH and LH
Cortisol
Oxytocin
Progesterone’s role includes:
Stimulating follicle growth
Triggering ovulation
Increasing uterine contractions
Sustaining pregnancy and preparing mammary glands
(Select all that apply) Inhibin secreted by gonads:
Suppresses FSH secretion
Provides negative feedback to pituitary
Increases GnRH release
Stimulates testosterone secretion
Testosterone is produced by:
Sertoli cells
Interstitial (Leydig) cells
Spermatogonia
Adrenal medulla
Testosterone functions to:
Promote male secondary sex characteristics
Inhibit sperm production
Reduce bone density
Stimulate lactation
The pineal gland produces:
ADH
Prolactin
Cortisol
Melatonin
Melatonin synthesis is greatest:
During daylight
During exercise
At night
After meals
(Select all that apply) Melatonin may influence:
Sleep cycles
Seasonal affective disorder (SAD)
Puberty timing
Appetite suppression
The hormone secreted by the heart in response to high blood pressure is:
Renin
Atrial natriuretic peptide (ANP)
Erythropoietin
Aldosterone
The kidneys produce:
Angiotensinogen
Melatonin
Erythropoietin
ACTH
The skin participates in endocrine function by:
Releasing insulin
Producing aldosterone
Secreting androgens
Converting cholesterol to vitamin D₃
The liver contributes to endocrine function by producing:
Angiotensinogen
Erythropoietin
Calcitonin
IGF-1
The placenta secretes which hormones during pregnancy?
Estrogen and progesterone
Cortisol and aldosterone
Insulin and glucagon
Melatonin and ANP
Calcitriol (active vitamin D₃) increases:
Calcium excretion
Calcium deposition into bone only
Calcium absorption from the intestine
Sodium reabsorption
(Select all that apply) Paracrine secretions differ from hormones in that they:
Have systemic effects
Are not secreted by neurons
Do not travel through the bloodstream
Act locally on nearby cells
Histamine functions as a paracrine by:
Causing vasoconstriction
Causing vasodilation and capillary permeability
Inhibiting smooth muscle contraction
Stimulating insulin release
Nitric oxide (NO) acts as a:
Hormone
Digestive enzyme
Neurotransmitter and paracrine vasodilator
Growth factor
Eicosanoids are derived from:
Arachidonic acid
Cholesterol
Tyrosine
Iodine
Leukotrienes are involved primarily in:
Lipid digestion
Glucose storage
Protein synthesis
Inflammatory and allergic responses
Prostaglandins function to:
Prevent smooth muscle contraction
Regulate diverse local processes
Replace damaged hormones
Promote gene transcription
Prostacyclin differs from thromboxane because prostacyclin:
Promotes clotting
Inhibits clotting and causes vasodilation
Stimulates platelet aggregation
Causes bronchoconstriction
Thromboxanes are produced by:
Neurons
Adipose cells
Blood platelets
Skeletal muscle
(Select all that apply) Chronic stress can lead to:
Suppressed immunity
Muscle wasting
Hypertension
Hypoglycemia
The stage of the stress response when glycogen reserves are depleted and cortisol dominates is:
Alarm reaction
Stage of resistance
Stage of exhaustion
Homeostasis
The hormone primarily responsible for long-term stress adaptation is:
Aldosterone
Epinephrine
Cortisol
Insulin
During the exhaustion stage of stress, death can result from:
Hypokalemia and alkalosis
Hyperglycemia and euphoria
High insulin levels
Bone overgrowth
