Font size
WorksheetsNUR 138 Pharmacology Antineoplastic Drugs
Total questions: 45
Worksheet time: 45mins
What is the primary characteristic of cancer cells that differentiates them from normal cells?
They have controlled growth and differentiation.
They lack growth control and differentiation.
They are always benign.
They do not invade other tissues.
Which type of tumor originates from epithelial tissue?
Sarcomas
Lymphomas
Carcinomas
Leukemias
What is the role of an oncogene in cancer development?
It spreads cancer from the primary site to distant organs.
It is a gene that promotes cancer development.
It is a substance that causes cancer.
It is an agent that causes DNA mutations.
Which treatment modality is primarily used to remove solid tumors?
Radiation
Chemotherapy
Surgery
Immunotherapy
What is the difference between cell cycle-specific and cell cycle-non-specific drugs?
Cell cycle-specific drugs kill cells in any phase, including resting.
Cell cycle-non-specific drugs kill cells in specific phases (S, M, G2).
Cell cycle-specific drugs kill cells in specific phases (S, M, G2).
Cell cycle-non-specific drugs only target solid tumors.
Which phase of the cell cycle do antimetabolites primarily act during?
G1 phase
S phase
G2 phase
M phase
What is a common adverse effect of methotrexate?
Peripheral neuropathy
Myelosuppression
Cardiotoxicity
Nephrotoxicity
Which of the following drugs is a pyrimidine analog?
Methotrexate
Mercaptopurine
5-FU
Vincristine
What is the primary nursing priority when administering methotrexate?
Monitor blood glucose levels
Leucovorin rescue
Administer antiemetics
Monitor heart rate
Which class of drugs acts during the M phase of the cell cycle?
Antimetabolites
Mitotic inhibitors
Alkylating agents
Topoisomerase inhibitors
Which of the following is a nursing priority when administering vincristine?
Monitor blood pressure
Never give intrathecally
Administer with food
Avoid sunlight exposure
What is the primary indication for the use of topotecan?
Breast cancer
Lung cancer
Ovarian cancer
Prostate cancer
Which adverse effect is associated with irinotecan?
Constipation
Severe diarrhea
Hypertension
Hair loss
What is the mechanism of action for antineoplastic enzymes like asparaginase?
Inhibit DNA replication
Deplete asparagine leading to cancer cell death
Block hormone receptors
Enhance immune response
What is a key nursing priority when administering alkylating agents?
Monitor blood pressure and heart rate
Monitor amylase/lipase, glucose, liver enzymes
Monitor respiratory rate and oxygen saturation
Monitor skin integrity and hydration levels
Which of the following is an example of a platinum compound used as an alkylating agent?
Cyclophosphamide
Cisplatin
Doxorubicin
Bleomycin
What adverse effect is associated with the use of busulfan?
Myelosuppression
Hemorrhagic cystitis
Nephrotoxicity
Pulmonary fibrosis
Which cytotoxic antibiotic group includes doxorubicin?
Nitrogen Mustards
Anthracyclines
Non-Anthracyclines
Platinum Compounds
What is a common use for both alkylating agents and cytotoxic antibiotics?
Treating bacterial infections
Treating viral infections
Treating solid and hematologic tumors
Treating cardiovascular diseases
Which of the following is a nursing priority when administering chemotherapy?
Monitor blood glucose levels
Monitor IV site for extravasation
Check blood pressure hourly
Administer oxygen therapy
What is a common adverse effect of doxorubicin?
Pulmonary fibrosis
Cardiotoxicity
Osteoporosis
Hot flashes
Which type of targeted therapy is Trastuzumab an example of?
Angiogenesis Inhibitors
Monoclonal Antibodies
TKIs
Hormonal Agents
What is a potential adverse effect of hormonal agents used in cancer treatment?
Myelosuppression
Thromboembolism
Vesicant injury
Hypertension
Which of the following therapies targets specific molecules in cancer cells with fewer effects on normal cells?
Chemotherapy
Targeted Therapy
Radiation Therapy
Immunotherapy
Which of the following is a priority in nursing related to patient education?
Monitoring IV site integrity
Educating on side effects and adherence
Administering cytoprotective agents
Managing nausea, mucositis, diarrhea
What is included in the assessment phase of the nursing process and safety?
Infection precautions
Administering cytoprotective agents
Baseline labs: CBC, renal, liver, cardiac, pulmonary
Managing nausea, mucositis, diarrhea
Which of the following is an implementation strategy in nursing care?
Monitoring bone density, clotting signs
Preventing extravasation
Oral care, hydration
Avoiding pregnancy during treatment
In the education phase, what precaution is advised during treatment?
Monitoring IV site integrity
Administering cytoprotective agents
Avoiding pregnancy
Managing nausea, mucositis, diarrhea
The nurse would anticipate administering what medication to patients receiving high-dose methotrexate?
Dactinomycin
Bleomycin
Leucovorin
Cisplatin
Nausea and vomiting are frequent adverse effects associated with antineoplastic therapy. What would the nurse advise patients to experience these unpleasant adverse effects?
Consider relaxation techniques because these symptoms should improve over time.
Increase intake of dry or high-fiber foods and foods with a rough texture.
Try to maintain hydration and nutrition, which are very important during treatment.
Administering antacids may alleviate gastric irritation, thereby reducing symptoms of nausea.
Current research has led to the discovery of cancer-causing viruses in humans. What virus is linked to cancer and can be prevented in humans?
Shope papillomavirus
Rous sarcoma virus
Human papillomavirus
Leukemia viruses
When teaching a patient to receive an antineoplastic drug, the nurse would instruct the patient about what common adverse effect? (Select all that apply.)
Weight gain
Joint pain
Hypertension
Heartburn
Vertigo
Combinations of antineoplastic drugs are frequently used for what purpose? (Select all that apply.)
Lower cost of treatment
Decrease drug tolerance
Decrease the severity of adverse effects
Prevent drug resistance
Provide a synergistic action
What is considered a significant dose-limiting adverse effect of doxorubicin?
Nephrotoxicity
Hepatoxicity
Cardiomyopathy
Hemorrhagic cystitis
When a patient is receiving tamoxifen, the nurse would suspect what type of cancer diagnosis?
Colon
Renal
Breast
Lung
The nurse should advise a patient receiving cyclophosphamide to drink plenty of fluids to prevent what condition?
Liver dysfunction
Neutropenia
Hemorrhagic cystitis
Respiratory failure
A patient is taking tamoxifen [Nolvadex] for the treatment of breast cancer with metastatic bone cancer. The nurse needs to assess the patient for the development of what?
Hyperphosphatemia
Hypercalcemia
Hypokalemia
Hyponatremia
A patient is receiving intravenous rituximab [Rituxan] for the treatment of B-cell non-Hodgkin’s lymphoma. During the administration of this medication, the nurse needs to assess the patient for the development of what?
Bone marrow suppression
Diarrhea, nausea, and abdominal pain
Hypotension, bronchospasm, and angioedema
Altered mental status and pulmonary congestion
The most critical concern for patients receiving tamoxifen therapy is the development of what?
Ovarian cancer
Endometrial cancer
Hodgkin’s disease
Leukemia
A patient is receiving androgen deprivation therapy for the treatment of prostate cancer. The nurse identifies all as adverse effects of androgen deprivation therapy except which?
Increased muscle mass
Gynecomastia
Hot flashes
Erectile dysfunction
A patient is receiving chemotherapy. Which laboratory result will most likely require chemotherapy to be withheld?
Platelet count of 157,000/mm3
Neutrophil count of 375/mm3
Hemoglobin of 12.2 g/dL
Partial thromboplastin time of 35 seconds
The nurse knows that severe nausea and vomiting from chemotherapy are caused by what?
Stimulation of the chemoreceptor trigger zone
Anxiety and anticipatory grieving
Increased peristalsis of the gastrointestinal tract
Injury of the epithelial lining of the esophagus and stomach
A patient receiving chemotherapy is anemic. Which medication does the nurse anticipate administering to this patient?
Filgrastim
Pegfilgrastim
Neumega
Erythropoietin
A patient with non-Hodgkin’s lymphoma is prescribed cyclophosphamide [Cytoxan]. What is essential for the nurse to teach the patient?
To observe for hepatotoxicity
That alopecia is a rare side effect of this medication
To take the medication on an empty stomach to reduce nausea
To increase fluid intake to prevent kidney damage
Vincristine [Oncovin] is prescribed for a patient with bladder cancer. The nurse will teach the patient that a common adverse effect of the medication is what?
Peripheral neuropathies
Hair loss
Nausea and vomiting
Bone marrow suppression
