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WorksheetsAutoimmunity and Transplantation Quiz
Total questions: 25
Worksheet time: 13mins
What is the main genetic factor in autoimmunity?
Fc receptors
ABO blood group
Rh factor
HLA genes
Which HLA class is primarily associated with CD4 T-cell–driven autoimmunity?
HLA-I (A, B, C)
HLA-II (DR, DQ, DP)
HLA-IV
HLA-III
Which HLA type is associated with myasthenia gravis, Graves disease, and SLE?
HLA-DR4
HLA-A
HLA-DR3
HLA-DQ
What is the memory hook for HLA-DR4 in rheumatoid arthritis?
DRives diseases
4 walls in a Rheum
Gas pedal glued down
Dairy Queen → gluten gut
Which sex is more likely to develop autoimmune diseases?
Men
Children
Women
Both equally
What is the mechanism of Type II-like autoimmunity?
Antibodies against cells/ECM
Complement activation
Immune complexes
Autoreactive T cells
Which autoimmune disease is Type III-like?
Celiac disease
Rheumatoid arthritis
SLE
Myasthenia gravis
What is the main mechanism in Type IV-like autoimmunity?
Immune complexes
Complement activation
Autoreactive T cells
Antibodies against ECM
What type of autoantibodies are found in myasthenia gravis?
Neutralizing
Agonistic
Complement-binding
Antagonistic
What is the result of autoantibodies binding ACh receptors in myasthenia gravis?
Muscle weakness
Joint inflammation
Hyperthyroidism
Skin blistering
What type of autoantibodies are found in Graves disease?
Agonistic
Complement-binding
Neutralizing
Antagonistic
What is the result of autoantibodies binding TSH receptors in Graves disease?
Skin blistering
Muscle weakness
Hypothyroidism
Hyperthyroidism
What structures form in Hashimoto’s thyroiditis due to lymphocyte infiltration?
Tertiary lymphoid structures
Fibrotic nodules
Primary lymph nodes
Granulomas
What is the initial target of autoantibodies in pemphigus?
Cadherins in tight junctions
EC5 domain of desmoglein
EC1 domain of desmoglein
EC2 domain of desmoglein
What type of epitope spreading occurs in SLE?
Intramolecular and intermolecular
Intramolecular only
No epitope spreading
Intermolecular only
What is the primary mechanism of IVIG in autoimmunity?
Flooding Fc receptors
Enhancing complement activation
Blocking T-cell activation
Neutralizing cytokines
Which HLA type is primarily involved in Type I diabetes?
HLA-A
HLA-DR4
HLA-DR3
HLA-DQ
What is the main mechanism in rheumatoid arthritis?
Autoantibodies to surface antigens
Immune complexes in vessels
CD8 T cells killing β-cells
CD4 T cells in synovium
What is the main mechanism in celiac disease?
CD4 T cells vs gluten peptides
CD8 T cells vs β-cells
Immune complexes in vessels
Autoantibodies to surface antigens
What is the main problem in hyperacute rejection of transplants?
T-cell activation
Fibrosis
Pre-formed antibodies
Ischemia
What type of rejection involves donor T cells attacking recipient tissues?
Chronic rejection
Hyperacute rejection
GVHD
Acute rejection
What is the main mechanism in chronic rejection?
Direct T-cell attack on graft
Immune complexes vs graft HLA-I
Complement activation
Pre-formed antibodies
What is the role of alloreactive T cells in acute rejection?
Direct pathway
Fibrosis
Indirect pathway
Complement activation
What is the role of immunosuppressants before transplantation?
Block chronic rejection
Limit hyperacute/acute rejection
Increase T-cell activation
Enhance complement activation
What is the main mechanism of ischemia during transplantation?
Complement activation
Immune complex deposition
Hypoxia and tissue damage
T-cell activation
