A characteristic morphologic feature in hemoglobin C disease is:

Thalassemias are characterized by:

Phagocytosis is a function of

Cells for the transport of 0₂ and CO₂ are:

Cells that produce antibodies and lymphokines are:

In polycythemia vera, the hemoglobin, hematocrit, red blood cell count, and red cell mass are:

In polycythemia vera, the platelet count is:

Erythropoietin acts to:

The anemia of chronic infection is characterized by:

Factors commonly involved in producing anemia in patients with chronic renal disease include:

The majority of the iron in an adult is found as a constituent of:

Which of the following is associated with Chediak-Higashi syndrome?

Which of the following is associated with Alder-Reilly inclusions?

In order for hemoglobin to combine reversibly with oxygen, the iron must be:

Heinz bodies are:

A bone marrow slide shows foam cells ranging from 20 to 100 pm in size with vacuolated cytoplasm containing sphingomyelin and is faintly PAS positive. This cell type is most characteristic of?

Patients with chronic granulomatous disease suffer from frequent pyogenic infections owing to the inability of:

Which of the following is most closely associated with iron deficiency anemia?

Which of the following is seen most often in thalassemia?

Which of the following is most likely to be seen in lead poisoning?

Auer rods are:

Morphologic variants of plasma cells do NOT include:

Pluripotent stem cells are capable of producing

The anemia found in myeloproliferative disorders is usually:

Hairy cell leukemia (leukemic reticuloendotheliosis) is:

Which of the following cell types is characteristic of Pelger Huet anomaly?

Which of the following is the formula for mean corpuscular volume (MCV)?

Which of the following is used for staining reticulocytes?

The characteristic erythrocyte found in pernicious anemia is:

The white cell feature most characteristic of pernicious anemia is

The ideal capillary blood collection site on a newborn is

In the normal adult, the spleen acts as a site for:

The term "shift to the left" refers to:

Of the following, the disease most closely associated with glucocerebrosidase deficiency is:

Of the following, the disease most closely associated with cytoplasmic granule fusion is:

The morphologic feature most characteristic of hemolytic anemia is:

The characteristic morphologic feature in lead poisoning is

The characteristic morphologic feature in folic acid deficiency is:

Which of the following characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?

Precursors of tissue macrophages of the reticuloendothelial system most likely are:

Which of the following cells are most likely identified in lesions of mycosis fungoides?

In normal adult bone marrow, the most common granulocyte is the:

Which of the following cells is the largest cell in the bone marrow:

Variation in red cell size observed on the peripheral smear is described as:

Which of the following is the preferable site for bone marrow aspiration and biopsy in an adult?

Which of the following erythrocyte inclusions can be visualized with supravital stain but cannot be detected on a Wright’s-stained blood smear?

Which of the following statistical terms reflects the best index of precision when comparing two CBC parameters

Which of the following is considered a normal hemoglobin?

Which condition will shift the oxyhemoglobin dissociation curve to the right

Which is the first stage of erythrocytic maturation in which the cytoplasm is pink due to the formation of hemoglobin?

Which of the following can shift the hemoglobin oxygen dissociation curve to the right?

Which of the following organs is responsible for the “pitting process” for RBCs?

Spherocytes differ from normal red cells in all of the following except:

Which is the major Hgb found in the RBCs of patients with sickle cell trait?

Select the amino acid substitution that is responsible for sickle cell anemia.

All of the following are usually found in Hgb C disease except:

Which of the following electrophoretic results is consistent with a diagnosis of sickle cell trait?

“Bite cells” are usually seen in patients with:

The morphological classification of anemias is based on which of the following?

Which of the following is a common finding in aplastic anemia?

Which antibiotic(s) is (are) most often implicated in the development of aplastic anemia

What red cell inclusion may be seen in the peripheral blood smear of a patient postsplenectomy?

Iron deficiency anemia is characterized by

Which anemia is characterized by a lack of intrinsic factor that prevents B12 absorption?

Which morphological classification is characteristic of megaloblastic anemia?

Which inclusions may be seen in leukocytes?

It is the process by which erythroid precursor cells differentiate to become mature RBC.

Components of quality assurance/assessment programs includes all of the following except?

Which of the following is not included in the examination/analytical phase of testing?

Which of the following is part of the preexamination/preanalytical phase of testing?

It is a sample of known quantity and are prepared from the same matrix as patient specimens and are sampled alongside patient specimens to accomplish within-run assay validation.

When controls are run, they must fall within predetermined dispersal limits, typically at ________________.

These are materials of known concentration used in developing a standard curve/for calibration of instrument.

These are materials used to adjust instrument accuracy by configuring an instrument to provide a result for a sample within an acceptable range.

The main cause of the error is due to improper calibration of the instrument causing an abrupt change in the mean.

The main cause of the error is due to deterioration of reagent causing 6 or more control values continue to either increase or decrease

It refers to the closeness of a measured value to a standard or known value.

It is a measure of the smallest increment/amount of the analyte that can be distinguished by the assay.

This error occurs when 4 consecutive control values exceeds +1s .

Primary site of hematopoiesis in Mesoblastic stage.

Primary site of hematopoiesis in Hepatic stage.

Cells that is produced as early as mesoblastic stage of hematopoiesis.

At what hematopoietic stage does Hgb F produced?

Which hemoglobin contains 2 alpha chains and 2 delta chains.

The bone marrow has two forms, which one is normally active in the production of most types of leukocytes, erythrocytes, and thrombocytes.

This is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells since the spleen becomes overactive and removes the blood cells too early and too quickly.

This is considered the first human hematopoietic growth factor to be identified.

Which of the following statement is incorrect as RBC matures?

Which of the following is incorrectly paired:

Which of the following RBC maturation stage does hemoglobin first appear?

Which of the following RBC maturation stage is not anymore capable of mitosis as well as the last nucleated stage.

Which protein maintains the biconcavity of the RBCs?

The loss of this important RBC component leads to loss of membrane deformability due to a decrease in phosphorylation of spectrin.

The RBC membrane is freely permeable to:

This pathway of RBC metabolism is the aerobic pathway.

It is the reference method for hemoglobin assay that is performed manually but has been adapted to automated instruments.

Which of the following is incorrect regarding anemia?

A type of anemia that is usually associated with traumatic conditions such as an accident or severe injury and an anemia that may occur during or after surgery.

A type of anemia that is frequently associated with disorders of the gastrointestinal (GI) tract, although chronic blood loss may be related to heavy menstruation in women or urinary tract abnormalities.

Which iatrogenic agents causes aplastic anemia when patients are exposed to burning gasoline for a long time.

It is considered the congenital form of aplastic anemia.

It is a compulsive ingestion of nonnutritive substances has association with iron deficiency.

A full manifestation of iron deficiency anemia will exhibit ___________________ red cell pattern.

It is considered an effective early indicator of iron deficiency.

This type of anemia is usually due to common complication in patients with disorders as diverse as inflammation, infection, malignancy.

This type of anemia is usually caused by an altered immune response resulting in production of antibody against the patient’s own erythrocytes, with subsequent hemolysis.

A type of autoimmune hemolytic anemia that is due to immunoglobulin G (IgG) coating of erythrocytes with or without complement fixation.

A type of autoimmune hemolytic anemia that is due to IgM antibody that coats the erythrocytes causing extra-vascular hemolysis.

Macrocytes are usually seen in all of the following except?

Which RBC shape is seen in abetalipoproteinemia and alcoholic cirrhosis.

This are erythrocytes containing one or more vacuoles that resemble a blister on the skin as a result from the traumatic interaction of blood vessels and circulating blood such as fibrin deposits.

When central pallor area exceeds 1/3 of the diameter of the cell, this is termed?

This RBC inclusion appears round, solid- staining, dark-blue to purple inclusions, 1 to 2 mm in size formed as nuclear remnants of DNA.

Which stage of thrombopoiesis shows a horseshoe shape nucleus.

Dense granules of platelets includes all of the following except?

2/3 of the circulating platelets are located in the _____.

Which granulocyte maturation stage has a kidney shaped nucleus?

Which granulocyte maturation stage does secondary granules occurs?

Which granulocyte maturation stage does primary granules occurs?

Which WBC type has pink to rose-violet specific granules.

Charcott-leyden crystals are formed from the disintegration of which WBC type?

Responds to parasitic and allergic reaction and its concentration is normally high at night.

The nucleus of this cell is eccentric and exhibits cartwheel like pattern and has well-defined hof/perinuclear halo in the cytoplasm

It refers to the inability of phagocytes to kill ingested

microorganisms.

It is a monocyte with ingested lymphocyte.

It is a plasma cell with red to pink cytoplasm that is found in multiple myeloma.

This lipid storage disease is mainly due to deficiency in Glucocerebrosidase or Beta-glucosidase.

This lipid storage disease is mainly due to deficiency in Sphingomyelinase.

It formed from degenerated /disintegrated nucleus of a ruptured white blood cell usually found in Chronic Lymphocytic

Leukemia (CLL).