It begins around the 19th day of embryonic development after fertilization

(a)  

They are found in the yolk sac arise from mesodermal cell

(a)  

They are important in early embryogenesis to produce hemoglobin

(a)  

It is needed for oxygen delivery for those developing tissues

(a)  

It is the 1st blood cell to be recognize in the mesoblastic phase

(a)  

It has a globin combination of 2 epsilon and 2 zeta

(a)  

It begisn at 5 to 7 gestational weeks

(a)  

What is the chief site of the mesoblastic phase?

(a)  

What is the chief site of hepatic phase

(a)  

What is the first fully developed organ in the fetus?

(a)  

It is the 4th or 5th month of fetal development, hematopoiesis begins in the bone marrow activity

(a)  

What is the chief site of the medullary phase

(a)  

What is the myeloid to erythroid ratio in the myeloid phase?

(a)  

It is a hormone that stimulates the production of RBC and helps to enhance the production of RBC

(a)  

What are the location of the hematopoietic tissue in adults?

(a)  

It contains the developing erythroid, myeloid, megakaryocytic and lymphoid cells

(a)  

It occurs in primary and secondary lymphoid tissue

(a)  

Its major function is the proliferation and production of blood cells

(a)  

haematopoietically active marrow consisting of developing blood cells and their progenitors

(a)  

Red marrow is found in the? (8)

(a)  

these are undifferentiated immature hematopoietic cells that is committed to a cell line but not identified

(a)  

haematopoietically inactive marrow composed primarily of adipocytes (fat cells), with undifferentiated mesenchymal cells and macrophages

(a)  

At what age is the yellow marrow abundant?

(a)  

process of replacing the active marrow by the yellow marrow. This occurs when there is profuse bleeding. Yellow marrow acts in cases of trauma

(a)  

Plays an important role in stem cell differentiation and proliferation

(a)  

It is responsible for supplying semifluid matrix (stroma) that serves as an anchor for the developing hematopoietic cells

(a)  

What is the composition of trauma/ stroma cells? (6)

(a)  

regulates the flow of particles entering and leaving hematopoietic spaces

(a)  

secrete various steroids that influence erythropoiesis and maintain bone integrity and regulates the volume of marrow

(a)  

function in phagocytosis and secretion of various cytokines that regulate hematopoiesis

(a)  

bone forming cells

(a)  

bone reabsorbing cells or destroying cells

(a)  

supports the vascular sinuses and developing hematopoietic cells

(a)  

serves as the major site of blood cell production during the second trimester of fetal development

(a)  

It is the graveyard where the senescent or dying cells goes

(a)  

Consist of scattered follicles with germinal centers containing lymphocytes, macrophages, and dendritic cells

(a)  

Composed primarily of vascular sinusoids and sinuses separated

(a)  

It surrounds the white pulp and forms a reticular meshwork containing blood vessels, macrophages, and specialized B cells

(a)  

Cells are phagocytized with subsequent degredation of cell organelles

(a)  

Splenic macrophages remove inclusions or damages surface membrane from the circulating RBCs

(a)  

It serves as a storage site for platelets

(a)  

It is the fluid portion of the blood and characterized by low protein region that escapes into the connective tissues

(a)  

it is the outer region of the lymph nodes and contains follicles of b cells

(a)  

It is the inner region of the lymph node that consist primarily of t lymphocytes and plasma cells

(a)  

It is the region between the cortex and medulla and contains predominantly T cells and numerous macrophages

(a)  

originates from the endodermal and mesenchumal tissues

(a)  

what is the source of GM-CSF? (3)

(a)  

What is the source of G-CSF? (2)

(a)  

What is the source of M-CSF? (3)

(a)  

What is the source of EPO?

(a)  

It regulates production of platelets form the MK1 to MK2 and platelets

(a)  

Refers to programmed cell death

(a)  

3 POSSIBLE ACTIVITIES OF HSCs

(a)  

It is a group of specific glycoproteins called growth factors, that regulates the proliferation differentiation, and maturation of hematopoietic precursor cells

(a)  

They work synergistically with thrombopoietin and helps in the production of platelets

(a)