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Red Blood Cell Quiz

Total questions: 110

Worksheet time: 3hrs 57mins

Name
Class
Date
1.

What is the composition of the RBC membrane?

a)

58% proteins, 40% lipids, 8% carbohydrates

b)

40% proteins, 58% lipids, 8% carbohydrates

c)

58% lipids, 40% proteins, 8% carbohydrates

d)

40% lipids, 58% proteins, 8% carbohydrates

2.

Which component of the RBC membrane provides tensile strength?

a)

Phospholipids

b)

Cholesterol

c)

Proteins

d)

Carbohydrates

3.

What property of RBCs allows them to stretch undamaged through narrow capillaries?

a)

Deformability

b)

Viscosity

c)

Elasticity

d)

Hemolysis

4.

Which phospholipid predominates in the outer layer of the RBC membrane?

a)

Phosphatidylcholine

b)

Phosphatidylserine

c)

Phosphatidylethanolamine

d)

Sphingomyelin

5.

What happens to the distribution of phosphatidylserine (PS) in the RBC membrane during aging or in certain diseases?

a)

It redistributes to the inner layer

b)

It redistributes to the outer layer

c)

It remains evenly distributed

d)

It is completely removed from the membrane

6.

Which proteins are part of the ankyrin complex in the RBC membrane?

a)

Band 3 and protein 4.2

b)

Protein 4.1 and actin

c)

Adducin and dematin

d)

Glut-1 and protein 4.1

7.

What is the function of aquaporin 1 in the RBC membrane?

a)

Regulates Na and K concentrations

b)

Maintains low intracellular calcium levels

c)

Forms pores for water flow

d)

Controls membrane deformability

8.

Which cation pumps maintain osmotic balance in the RBC?

a)

Na-ATPase and K-ATPase

b)

Ca-ATPase and Na-ATPase

c)

K-ATPase and Ca-ATPase

d)

Na-ATPase and Ca-ATPase

9.

What happens when there is a defect in the horizontal interaction of spectrin in the RBC membrane?

a)

The RBC becomes spheroid

b)

The RBC swells and ruptures

c)

The RBC loses deformability

d)

The RBC forms small blebs

10.

Which condition is associated with an increased plasma bile salt concentration and a target cell appearance of RBCs?

a)

Sickle cell anemia

b)

Thalassemia

c)

Overhydrated stomatocytosis

d)

Liver disease

11.

Cytoskeletal or Peripheral proteins has a principle of

a)

alpha and beta spectrin

b)

ankyrin and actin complexes

c)

band 3

12.

the process in which cell swells, becomes spheroid, and ruptures

a)

hemolysis

b)

cell hemolysis

c)

colloid osmotic hemolysis

d)

RBC hemolysis

13.

Defect in ion channels causes

a)

Overdehydrated stomatocytosis (hereditary hydrocytosis)

b)

sickle cell anemia

c)

hereditary elliptocytosis

d)

dehydrated stomatocytosis (hereditary xerocytosis)

14.

calmodulin is responsible for

a)

medication for calcium

b)

Ca-ATPase

c)

Na-ATPase

d)

K-ATPase

15.

Ratio for intracellular:extracellular

a)

50:50

Na:K

b)

1:12

Na:K

c)

25:1

Na:K

d)

60:40

Na:K

16.

decreased aquapohorin 1 result in

a)

IDA

b)

hereditary stomtocytosis

c)

hereditary spherocytosis

d)

hereditary elliptocytosis

17.

PPL that predominates the OUTER LAYER

4 lines
18.

PPL that predominates the INNER LAYER

4 lines
19.

a type of PPL that is negatively charged

a)

Phosphatidylcholine

b)

Phosphatidylserine

c)

Phosphatidylethanolamine

20.

RBC is _ and _

(a)  

21.

Function/s of Transmembrane protein or Integral protein

a)

transport site

b)

adhesion site

c)

surface receptors

d)

provides vertical membrane structure

22.

also called as Protein 4.2

a)

ankyrin and actin

b)

Na and K

c)

Ca and K

d)

Na, Ca, and K

23.

this dye is used to stain GLYCOPHORINS

a)

periodic-acid schiff

b)

coomasie blue dye

c)

methylene blue

d)

wright stain

24.

Bands migrate through the gel, with their velocity a property of  their molecular weight and net charge, and are identified

a)

coomasie blue dye

b)

SDS-PAGE

c)

Periodic - acid schiff

d)

wright stain

25.

dye that is used to distinguish membrane proteins or for protein identification

a)

Methylene blue

b)

Periodic Acid Schiff

c)

coomasie blue dye

d)

SDS-PAGE

26.

lifespan of RBC

a)

60 days

b)

120 days

c)

365 days

d)

30 days

27.

responsible for the red pigment of RBC

a)

heme

b)

hemoglobin

c)

iron

d)

protein

28.

average volume of RBC

a)

150fL

b)

90fL

c)

120fL

d)

60fL

29.

average size of RBC (diameter)

a)

3.5

b)

7.2

c)

10.5

d)

5.8

30.

enumerate the 4 METABOLIC PATHWAYS

4 lines
31.

embden-meyerhof pathway is a/an

a)

aerobic pathway

b)

anaerobic pathway

32.

hexose monophosphate shunt is a/an

a)

aerobic pathway

b)

anaerobic pathway

33.

where 90% of glycolytic reaction happens

a)

Methemoglobin reductase pathway (MRP)

b)

embden meyerhof pathway (EMP)

c)

Hexose Monophosphate pathway (HMP)

d)

Rapoport luebering pathway (RLP)

34.

1 glucose is coverted into

a)

lactate and pyruvate

b)

glycogen and atp

c)

atp

35.

with a series of biochemical reactions, 2 atps are produced

1 ATP is used for _

and 1 ATP is used for _

a)

energy

strength

b)

Na and K pump

Flexibility

c)

energy

deformability

d)

Ca, K, and Na pump

energy

36.

cation that is kept INTRACELLULARY

or found INSIDE the RBC

a)

protein

b)

Na

c)

K

d)

Ca

37.

cation that is kept EXTRACELLULARY

or found OUTSIDE the RBC

a)

protein

b)

Na

c)

K

d)

Ca

38.

young RBC

a)

increased glucose, ATP, glycophorin, cholesterol

decreased Ca

b)

decreased glucose, ATP, glycophorin, cholesterol

increased Ca

39.

mature RBC / old RBC

a)

increased glucose, ATP, glycophorin, cholesterol

decreased Ca

b)

decreased glucose, ATP, glycophorin, cholesterol

increased Ca

40.

glucose enters the RBC via

a)

transferrin

b)

transmembrane protein-glut 1

c)

Na-ATPase, K-ATPase, and Ca-ATPase

d)

pyruvate and lactate

41.

RBC is negatively charged because of

a)

glycophorin

b)

protein

c)

lipid

d)

cholesterol

42.

the ability of the RBC to disperse and not to agglutinate is because of

a)

carbohydrate

b)

glycophorin

c)

protein

d)

zeta potential

43.

where 10% of glucose is used

a)

MRP

b)

EMP

c)

RLP

d)

HMS

44.

NADP reduced = NADPH

NADPH oxidizes glutathione to its reduced form = GSH

in the process called

a)

glutathione reductase

b)

glutathione peroxidase

45.

reduced glutathione becomes oxidized and reduce peroxide in the process called

a)

glutathione reductase

b)

glutathione peroxidase

46.

heinz bodies are REVERSIBLE

a)

false

b)

true

c)

maybe

47.

macrophage engulfs heinz bodies in the young RBC

a)

target cells

b)

splenic pitting

c)

splenic culling

d)

bite cells

48.

engulfs heinz bodies or other inclusion bodies

a)

bite cells

b)

splenic pitting

c)

splenic culling

d)

spherocyte

49.

maintains iron in the ferrous state by the process called

4 lines
50.

ferrous (2+)

4 lines
51.

ferric (3+)

4 lines
52.

a pathway that produces 2-3 DPG and 2-3 BPG

a)

RLP

b)

MRP

c)

EMP

d)

PPP

53.

2-3 BPG binds to the heme portion

a)

true

b)

false

54.

2-3 BPG has oxygen attached to it

a)

true

b)

false

55.

meaning of 2,3 DPG

4 lines
56.

meaning of 2,3 BPG

4 lines
57.

describe the dynamics of RBC production and destruction

a)

erythropoiesis

b)

hematopoiesis

c)

erythrokinetics

d)

RBC

58.

it is the movement of water from low and high gradient

a)

hypotonic

b)

osmosis

c)

osmotic lysis

d)

hypertonic

59.

a process where the water in the plasma enters the RBC

a)

hemolysis

b)

osmotic lysis

c)

osmosis

60.

hypotonic = <0.85 NaCl (higher concentration OUTSIDE)

a)

true

b)

false

61.

hypertonic = >0.85 NaCl (higher concentration INSIDE)

a)

true

b)

false

62.

happens when the RBC produce heinz bodies: due to weak HMP

a)

hemoglobin denaturation

b)

intravascular lysis

c)

extravascular lysis

d)

NADP

63.

lysis with the circulation is called

4 lines
64.

10-20% of old RBC undergo INTRAVASCULAR LYSIS

a)

true

b)

false

65.

90% of old RBC undergo MACROPHAGE-MEDIATED HEMOLYSIS

a)

false

b)

true

66.

if haptoglobin is depleted, alpha and beta dimers will become

a)

free hb

b)

converted into hemosiderin

c)

oxidized into methemoglobin

d)

NOTHING WILL HAPPEN

67.

normal RBC count in men

4 lines
68.

normal RBC count in women

4 lines
69.

normal RBC count in during late pregnancy

4 lines
70.

normal RBC count at birth

4 lines
71.

normal RBC count in infants

4 lines
72.

<1/3 central pallor

a)

hyperhemoglobin

b)

hypohemoglobin

73.

>1/3 central pallor

a)

hyperhemoglobin

b)

hypohemoglobin

74.

MCHCs < 36% compromise deformability and shorten the RBC life span

a)

true

b)

false

75.

variation in hb content

4 lines
76.

variation in staining property

4 lines
77.

variation in cell size

4 lines
78.

variation in cell shape

4 lines
79.

What is the morphology of cells which are Fe deficient?

a)

normochromic

b)

Hypochromic microcytic

c)

Hypochromic macrocytic

d)

Hyperchromic microcytic

80.

faulty Fe metabolism due to enzyme error

a)

spherocyte

b)

IDA

c)

sideroblastic anemia

d)

thalassemia

81.

give at least 3 disease under hypochromia

4 lines
82.

give at least 2 disease under ANISOCHROMIA

4 lines
83.

give at least 3 disease under POLYCHROMASIA

4 lines
84.

give at least 3 disease under BASOPHILIC STIPPLING

4 lines
85.

give at least 3 disease under HYPOCHROMASIA

4 lines
86.

give at least 3 disease under HYPERCHROMASIA

4 lines
87.

give at least 3 disease under MACROCYTE

4 lines
88.

give at least 3 disease under MICROCYTE

4 lines
89.

give at least 3 disease under MEGALOCYTE

4 lines
90.

give at least 3 disease under target cell

4 lines
91.

give at least 3 disease under ELLIPTOCYTE

4 lines
92.

give at least 3 disease under SPHEROCYTE

4 lines
93.

give at least 3 disease under SCHISTOCYTE

4 lines
94.

give at least 3 disease under DACRYOCYTE

4 lines
95.

give at least 3 disease under SICKLE CELL

4 lines
96.

give at least 3 disease under ECHINOCYTE

4 lines
97.

give at least 3 disease under ACANTHOCYTE

4 lines
98.

schuffner's dots is seen in what type of plasmodium

4 lines
99.

jame's dots is seen in what type of plasmodium

4 lines
100.

ziemman's dots is seen in what type of plasmodium

4 lines
101.

maurer's dots is seen in what type of plasmodium

4 lines
102.

comma-shaped inclusion bodies

intravital stain

4 lines
103.

maltese cross inclusion bodies

wright stain

4 lines
104.

stain used in siderocytes

4 lines
105.

DNA remnants

romanowsky stain

4 lines
106.

staining for heinz bodies

4 lines
107.

stain used for pappenheimer bodies

4 lines
108.

stain used for Hemoglobin H

4 lines
109.

characteristics of RBC thoma pipette

4 lines
110.

enumerate 7 diluting fluids used in RBC counting

4 lines

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