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Blood Group Terminology and Common Blood Groups Quiz

Total questions: 71

Worksheet time: 36mins

Name
Class
Date
1.

What are the two most significant blood groups in transfusion practice?

a)

ABO and Rh

b)

MNS and Duffy

c)

Kell and Kidd

d)

Lewis and P

2.

How many RBC antigens are currently recognized internationally?

a)

446

b)

146

c)

256

d)

346

3.

What is the primary component that defines blood group antigens?

a)

Nucleic acids

b)

Carbohydrates

c)

Proteins

d)

Lipids

4.

Which blood group system is known for its antibodies being naturally occurring?

a)

ABO

b)

MNS

c)

Rh

d)

Lewis

5.

What is the term for alleles that do not produce any antigen?

a)

Codominant

b)

Dominant

c)

Silent

d)

Amorphic

6.

Which blood group system has been assigned the ISBT number 007?

a)

Kell

b)

Rh

c)

Lewis

d)

Duffy

7.

What is the main function of glycosyltransferases in blood group systems?

a)

To destroy antigens

b)

To synthesize carbohydrate epitopes

c)

To transport oxygen

d)

To regulate blood pressure

8.

Which blood group system includes the antigens M and N?

a)

ABO

b)

MNS

c)

Rh

d)

Lewis

9.

What is the phenotype of an individual with the genotype Kk?

a)

K+

b)

K–

c)

K+k

d)

K+K+

10.

What is the role of the International Society of Blood Transfusion (ISBT)?

a)

To regulate blood donations

b)

To classify blood group systems

c)

To develop new blood tests

d)

To provide blood transfusions

11.

Which blood group system is associated with the presence of anti-Le antibodies?

a)

Rh

b)

ABO

c)

Lewis

d)

MNS

12.

What is the significance of the null phenotype in blood group systems?

a)

It indicates a rare blood type

b)

It helps in antibody identification

c)

It has no clinical significance

d)

It is a common blood type

13.

Which of the following is a characteristic of the Lewis blood group system?

a)

Antigens are only found in the liver

b)

Antigens are only found in saliva

c)

Antigens are absorbed from plasma

d)

Antigens are intrinsic to RBCs

14.

What is the primary genetic inheritance pattern of most blood group genes?

a)

Polygenic

b)

Mendelian

c)

Autosomal recessive

d)

X-linked

15.

Which blood group system is known for having high-prevalence antigens?

a)

ABO

b)

MNS

c)

P

d)

Lewis

16.

What is the main characteristic of antibodies in the MNS blood group system?

a)

They can be either IgG or IgM

b)

They are always IgM

c)

They are always IgG

d)

They are only found in children

17.

What is the effect of enzyme treatment on M and N antigens?

a)

Enhances their reactivity

b)

Only affects M antigens

c)

Destroys their reactivity

d)

Has no effect

18.

Which blood group system includes the antigens S and s?

a)

ABO

b)

MNS

c)

Lewis

d)

Rh

19.

What is the primary structure that carries the M and N antigens?

a)

Proteins

b)

Glycophorin B

c)

Glycophorin A

d)

Glycolipids

20.

What is the prevalence of the M+N– phenotype in whites?

a)

28%

b)

50%

c)

11%

d)

22%

21.

Which blood group system is associated with the U antigen?

a)

Rh

b)

MNS

c)

ABO

d)

Lewis

22.

What is the primary function of the ISBT numeric system?

a)

To replace traditional terminology

b)

To facilitate computer storage

c)

To classify blood types

d)

To identify blood donors

23.

What is the term for the genetic makeup of an individual regarding blood groups?

a)

Phenotype

b)

Genotype

c)

Allele

d)

Antigen

24.

Which blood group system is known for its antibodies being clinically significant?

a)

Lewis

b)

ABO

c)

Rh

d)

MNS

25.

What is the main characteristic of anti-M antibodies?

a)

They are always IgM

b)

They are always IgG

c)

They are naturally occurring

d)

They are only found in children

26.

What is the primary component of the Lewis blood group antigens?

a)

Proteins

b)

Carbohydrates

c)

Lipids

d)

Nucleic acids

27.

Which blood group system has the highest number of recognized antigens?

a)

MNS

b)

Lewis

c)

ABO

d)

Rh

28.

What percentage of whites are antigen negative for the S antigen?

a)

11%

b)

45%

c)

69%

d)

3%

29.

Which amino acid is associated with the S/s antigen?

a)

Glycine

b)

Methionine

c)

Serine

d)

Threonine

30.

What is the prevalence of S– units in blacks?

a)

3%

b)

11%

c)

69%

d)

45%

31.

What type of antibodies can cause severe HTRs and HDFN?

a)

Anti-K

b)

Anti-U

c)

Anti-S

d)

Anti-Fy

32.

What is the structure carrying the M and N antigens?

a)

Glycophorin C

b)

Glycophorin B

c)

Glycophorin A

d)

Glycophorin D

33.

How many amino acids does Glycophorin A consist of?

a)

20

b)

44

c)

131

d)

72

34.

What is the hydrophilic terminal end of GPA composed of?

a)

36 amino acids

b)

20 amino acids

c)

44 amino acids

d)

72 amino acids

35.

What is the function of NeuNAc in RBCs?

a)

Decreases sialic acid

b)

Provides positive charge

c)

Provides negative charge

d)

Increases sialic acid

36.

What is the genetic location of the GYPA and GYPB genes?

a)

Chromosome 4

b)

Chromosome 19

c)

Chromosome 7

d)

Chromosome 1

37.

What is the prevalence of the U antigen in African Americans?

a)

45%

b)

11%

c)

3%

d)

1%

38.

What type of antibodies are typically produced by U– individuals?

a)

Anti-Jk

b)

Anti-U

c)

Anti-S

d)

Anti-K

39.

What is the primary cause of the En(a–) phenotype?

a)

Chromosomal inversion

b)

Point mutation

c)

Gene duplication

d)

Gene deletion

40.

What is the prevalence of the M phenotype in whites?

a)

20%

b)

99%

c)

50%

d)

80%

41.

What is the primary function of the Kell glycoprotein?

a)

Transport amino acids

b)

Transport oxygen

c)

Transport urea

d)

Transport glucose

42.

What is the prevalence of the K antigen in whites?

a)

9%

b)

45%

c)

69%

d)

3%

43.

What is the most common antibody seen in the blood bank outside of ABO and Rh?

a)

Anti-K

b)

Anti-S

c)

Anti-U

d)

Anti-Jk

44.

What is the prevalence of the Fy(a–b–) phenotype in African Americans?

a)

80%

b)

50%

c)

20%

d)

Very rare

45.

What is the primary antigen associated with the Duffy blood group system?

a)

Fy5

b)

Fy3

c)

Fy(b)

d)

Fy(a)

46.

What is the Kidd blood group system designated by?

a)

Jk

b)

JKD

c)

JK

d)

Jk3

47.

What is the prevalence of Jk(a+) in blacks?

a)

77%

b)

28%

c)

57%

d)

91%

48.

What is the most common antibody in the Kidd blood group system?

a)

Anti-K

b)

Anti-Jk(b)

c)

Anti-Jk(a)

d)

Anti-Jk3

49.

What is the prevalence of the Lu(a+b+) phenotype in whites?

a)

2%

b)

7.5%

c)

8%

d)

5%

50.

What is the primary function of the Lutheran glycoprotein?

a)

Signal transduction

b)

Nutrient transport

c)

Cell adhesion

d)

Oxygen transport

51.

What is the prevalence of the Lu(a–b–) phenotype?

a)

99%

b)

50%

c)

Common

d)

Very rare

52.

What is the primary cause of anti-Ku antibodies?

a)

Kell null phenotype

b)

Duffy null phenotype

c)

Kidd null phenotype

d)

Lutheran null phenotype

53.

What is the primary antigen associated with the Lutheran blood group system?

a)

Lu(a)

b)

Lu4

c)

Lu(b)

d)

Lu3

54.

What is the prevalence of the Jk(a–b–) phenotype in Polynesians?

a)

Exceedingly rare

b)

Common

c)

50%

d)

99%

55.

What is the primary antibody associated with the Duffy blood group system?

a)

Anti-Fy3

b)

Anti-Fy5

c)

Anti-Fy(b)

d)

Anti-Fy(a)

56.

What is the prevalence of the Fy(a+) phenotype in whites?

a)

17%

b)

34%

c)

50%

d)

80%

57.

What is the primary function of the Kidd glycoprotein?

a)

Oxygen transport

b)

Urea transport

c)

Signal transduction

d)

Nutrient transport

58.

What is the prevalence of the Jk(a+b+) phenotype in whites?

a)

49%

b)

91%

c)

28%

d)

77%

59.

What is the primary antigen associated with the Kell blood group system?

a)

Kp(a)

b)

K

c)

Kp(b)

d)

k

60.

What is the prevalence of the Kp(a+) phenotype in whites?

a)

2.3%

b)

0.2%

c)

8.8%

d)

99%

61.

What is the primary antibody associated with the Kell blood group system?

a)

Anti-Kp(a)

b)

Anti-k

c)

Anti-K

d)

Anti-Kp(b)

62.

What is the prevalence of the Js(a+) phenotype in blacks?

a)

99%

b)

80%

c)

50%

d)

20%

63.

What is the primary function of the Duffy glycoprotein?

a)

Chemokine receptor

b)

Signal transduction

c)

Oxygen transport

d)

Nutrient transport

64.

What is the prevalence of the Fy(b+) phenotype in whites?

a)

80%

b)

50%

c)

34%

d)

17%

65.

What is the primary antigen associated with the Kidd blood group system?

a)

Jk4

b)

Jk3

c)

Jk(b)

d)

Jk(a)

66.

What is the prevalence of the Jk(a+b+) phenotype in blacks?

a)

91%

b)

28%

c)

77%

d)

49%

67.

What is the primary function of the Kell glycoprotein?

a)

Transport urea

b)

Transport oxygen

c)

Transport glucose

d)

Transport amino acids

68.

What is the prevalence of the K antigen in blacks?

a)

9%

b)

45%

c)

69%

d)

3%

69.

What is the primary antibody associated with the Duffy blood group system?

a)

Anti-Fy(a)

b)

Anti-Fy(b)

c)

Anti-Fy5

d)

Anti-Fy3

70.

What is the prevalence of the Jk(a–b–) phenotype in whites?

a)

Very rare

b)

Common

c)

50%

d)

99%

71.

What is the primary function of the Kidd glycoprotein?

a)

Urea transport

b)

Oxygen transport

c)

Nutrient transport

d)

Signal transduction

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