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Cancer MCQs

Total questions: 100

Worksheet time: 50mins

Name
Class
Date
1.

What is the hallmark of cancer cells?

a)

Limited proliferation

b)

Apoptosis resistance

c)

Increased differentiation

d)

Decreased angiogenesis

2.

Which of the following is a tumor suppressor gene?

a)

RAS

b)

MYC

c)

TP53

d)

HER2

3.

The Warburg effect in cancer cells refers to:

a)

Increased oxygen consumption

b)

Reduced glycolysis

c)

Enhanced aerobic glycolysis

d)

Mitochondrial hyperactivity

4.

Which process allows cancer cells to spread from the primary tumor to distant sites?

a)

Apoptosis

b)

Metastasis

c)

Autophagy

d)

Differentiation

5.

Which tumor marker is primarily used for prostate cancer screening?

a)

CEA

b)

AFP

c)

PSA

d)

CA-125

6.

Elevated levels of Alpha-fetoprotein (AFP) are associated with:

a)

Breast cancer

b)

Liver cancer

c)

Colon cancer

d)

Lung cancer

7.

CA-125 is a marker primarily used for detecting:

a)

Ovarian cancer

b)

Pancreatic cancer

c)

Gastric cancer

d)

Skin cancer

8.

HER2 overexpression is commonly seen in:

a)

Lung cancer

b)

Breast cancer

c)

Prostate cancer

d)

Thyroid cancer

9.

Immunohistochemistry (IHC) is primarily used to:

a)

Detect circulating tumor cells

b)

Identify specific proteins in tissues

c)

Analyze DNA mutations

d)

Measure serum tumor markers

10.

The Philadelphia chromosome is associated with which cancer?

a)

Chronic myeloid leukemia (CML)

b)

Breast cancer

c)

Lung cancer

d)

Melanoma

11.

Which of the following is a characteristic of benign tumors?

a)

Invasive growth

b)

Well-differentiated cells

c)

High metastatic potential

d)

Rapid, uncontrolled division

12.

Oncogenes are genes that:

a)

Suppress tumor formation

b)

Promote uncontrolled cell growth

c)

Repair damaged DNA

d)

Induce apoptosis

13.

Which of the following pathways is commonly activated in cancer cells?

a)

Wnt/β-catenin

b)

Insulin signaling

c)

G-protein coupled receptor signaling

d)

TCA cycle

14.

Loss of function in which of the following genes leads to defective DNA repair mechanisms?

a)

BRCA1

b)

MYC

c)

KRAS

d)

VEGF

15.

Tumor angiogenesis is stimulated by:

a)

TNF-alpha

b)

VEGF

c)

E-cadherin

d)

Caspase-3

16.

CEA (Carcinoembryonic Antigen) is a tumor marker primarily used for:

a)

Breast cancer

b)

Colorectal cancer

c)

Pancreatic cancer

d)

Ovarian cancer

17.

A high level of hCG (human chorionic gonadotropin) is associated with:

a)

Testicular and trophoblastic tumors

b)

Lung cancer

c)

Thyroid cancer

d)

Pancreatic cancer

18.

Which tumor marker is commonly used in pancreatic cancer?

a)

CA-19-9

b)

CEA

c)

PSA

d)

CA-125

19.

Which molecular marker is used for targeted therapy in lung cancer?

a)

EGFR

b)

HER2

c)

BRCA1

d)

CA-125

20.

A mutation in the BRAF gene is commonly associated with:

a)

Colorectal cancer

b)

Melanoma

c)

Prostate cancer

d)

Ovarian cancer

21.

Which of the following is NOT a hallmark of cancer?

a)

Sustained angiogenesis

b)

Evasion of apoptosis

c)

Decreased cell proliferation

d)

Ability to metastasize

22.

Which of the following is an anti-apoptotic protein that promotes cancer cell survival?

a)

Bax

b)

Bcl-2

c)

Caspase-3

d)

P53

23.

Which enzyme is responsible for maintaining telomere length in cancer cells?

a)

DNA polymerase

b)

Telomerase

c)

Ligase

d)

Topoisomerase

24.

Which type of gene is involved in preventing uncontrolled cell growth?

a)

Oncogenes

b)

Tumor suppressor genes

c)

Proto-oncogenes

d)

Homeotic genes

25.

Which protein is known as the "guardian of the genome"?

a)

Rb

b)

p53

c)

Cyclin D

d)

Akt

26.

Loss of function of which gene leads to hereditary breast cancer?

a)

BRCA1

b)

HER2

c)

KRAS

d)

TP53

27.

The epithelial-to-mesenchymal transition (EMT) in cancer is primarily associated with:

a)

Angiogenesis

b)

Metastasis

c)

Tumor initiation

d)

DNA repair

28.

Inherited mutations in the APC gene are associated with which type of cancer?

a)

Breast cancer

b)

Colorectal cancer

c)

Lung cancer

d)

Pancreatic cancer

29.

Which tumor marker is most commonly used to monitor hepatocellular carcinoma?

a)

CEA

b)

AFP

c)

CA-19-9

d)

PSA

30.

Which molecular marker is targeted by the drug trastuzumab (Herceptin)?

a)

EGFR

b)

HER2

c)

BRCA1

d)

KRAS

31.

Mutations in which gene are commonly found in pancreatic cancer?

a)

BRCA2

b)

KRAS

c)

EGFR

d)

TP53

32.

Which of the following tumor markers is used for medullary thyroid carcinoma?

a)

Thyroglobulin

b)

CEA

c)

Calcitonin

d)

CA-125

33.

Elevated CA-19-9 levels are most often associated with:

a)

Gastric cancer

b)

Pancreatic cancer

c)

Breast cancer

d)

Ovarian cancer

34.

Lynch syndrome is associated with mutations in:

a)

Mismatch repair genes

b)

BRCA1

c)

RAS

d)

MYC

35.

A mutation in the VHL gene is associated with:

a)

Retinoblastoma

b)

Von Hippel-Lindau syndrome

c)

Multiple myeloma

d)

Colorectal cancer

36.

Which of the following tumor markers is used to detect choriocarcinoma?

a)

AFP

b)

β-hCG

c)

CA-125

d)

CEA

37.

The presence of BCR-ABL fusion protein is a hallmark of:

a)

Acute lymphoblastic leukemia (ALL)

b)

Chronic myeloid leukemia (CML)

c)

Lung cancer

d)

Breast cancer

38.

Which of the following is a major risk factor for hepatocellular carcinoma?

a)

HPV infection

b)

Hepatitis B and C infection

c)

Smoking

d)

Helicobacter pylori infection

39.

The presence of microsatellite instability (MSI) is a hallmark of:

a)

Lynch syndrome

b)

Retinoblastoma

c)

Small cell lung cancer

d)

Gastric adenocarcinoma

40.

A mutation in the NF1 gene is associated with:

a)

Neurofibromatosis type 1

b)

Melanoma

c)

Colon cancer

d)

Lung cancer

41.

Which of the following is a key feature of cancer cells?

a)

Contact inhibition

b)

Uncontrolled proliferation

c)

Shortened lifespan

d)

Decreased telomerase activity

42.

The two-hit hypothesis is associated with which tumor suppressor gene?

a)

p53

b)

BRCA1

c)

RB1

d)

APC

43.

Which gene mutation is most frequently associated with human cancers?

a)

MYC

b)

KRAS

c)

TP53

d)

EGFR

44.

Which type of cancer is most commonly caused by HPV infection?

a)

Liver cancer

b)

Cervical cancer

c)

Lung cancer

d)

Pancreatic cancer

45.

Tumor cells that undergo epithelial-to-mesenchymal transition (EMT) show:

a)

Reduced motility

b)

Decreased metastatic potential

c)

Loss of cell-cell adhesion

d)

Increased differentiation

46.

Which of the following is NOT a tumor suppressor gene?

a)

RB1

b)

p53

c)

KRAS

d)

APC

47.

The activation of which enzyme allows cancer cells to maintain telomere length?

a)

Telomerase

b)

DNA ligase

c)

Caspase-9

d)

Reverse transcriptase

48.

The Knudson Hypothesis explains the development of:

a)

Lung cancer

b)

Retinoblastoma

c)

Prostate cancer

d)

Leukemia

49.

Mutations in mismatch repair (MMR) genes lead to:

a)

Hereditary non-polyposis colorectal cancer (HNPCC)

b)

Breast cancer

c)

Lung cancer

d)

Melanoma

50.

Which of the following viruses is associated with Burkitt’s lymphoma?

a)

HPV

b)

Epstein-Barr virus (EBV)

c)

Hepatitis B virus (HBV)

d)

Human immunodeficiency virus (HIV)

51.

Which tumor marker is commonly used for testicular cancer?

a)

PSA

b)

β-hCG

c)

CA-19-9

d)

CEA

52.

BRCA1 and BRCA2 mutations are associated with an increased risk of:

a)

Lung cancer

b)

Breast and ovarian cancer

c)

Colorectal cancer

d)

Liver cancer

53.

The presence of Philadelphia chromosome (t[9;22]) is associated with:

a)

Hodgkin’s lymphoma

b)

Chronic myeloid leukemia (CML)

c)

Lung cancer

d)

Multiple myeloma

54.

A tumor marker used for monitoring colorectal cancer is:

a)

CA-125

b)

CEA

c)

AFP

d)

β-hCG

55.

Which tumor marker is used to diagnose hepatocellular carcinoma?

a)

CA-19-9

b)

AFP

c)

PSA

d)

LDH

56.

Which cancer is associated with an elevated calcitonin level?

a)

Prostate cancer

b)

Medullary thyroid carcinoma

c)

Pancreatic cancer

d)

Ovarian cancer

57.

Elevated serum CA-125 is most indicative of:

a)

Liver cancer

b)

Ovarian cancer

c)

Colon cancer

d)

Prostate cancer

58.

Which of the following markers is commonly used in the diagnosis of multiple myeloma?

a)

Beta-2 microglobulin

b)

PSA

c)

HER2

d)

AFP

59.

A mutation in the RET proto-oncogene is associated with:

a)

Medullary thyroid carcinoma

b)

Breast cancer

c)

Colorectal cancer

d)

Pancreatic cancer

60.

Which genetic mutation is associated with melanoma?

a)

BRAF V600E

b)

ALK rearrangement

c)

APC mutation

d)

JAK2 mutation

61.

Which of the following is a common characteristic of malignant tumors?

a)

Encapsulation

b)

Slow growth

c)

Invasion and metastasis

d)

Well-differentiated cells

62.

Which oncogene is most frequently mutated in human cancers?

a)

MYC

b)

KRAS

c)

HER2

d)

TP53

63.

Angiogenesis in tumors is primarily driven by:

a)

E-cadherin

b)

Caspase-9

c)

VEGF

d)

Cyclin D

64.

The mutator phenotype hypothesis suggests that cancer arises due to:

a)

Increased apoptosis

b)

Loss of DNA repair mechanisms

c)

Suppression of oncogenes

d)

Overexpression of tumor suppressor genes

65.

The main function of RB1 in normal cells is to:

a)

Promote cell cycle progression

b)

Prevent excessive cell division

c)

Induce apoptosis

d)

Activate oncogenes

66.

Which of the following viruses is linked to hepatocellular carcinoma?

a)

HPV

b)

Hepatitis B and C viruses

c)

Epstein-Barr virus

d)

HIV

67.

The P53 tumor suppressor gene regulates:

a)

DNA replication

b)

Cell cycle arrest and apoptosis

c)

Protein synthesis

d)

Tumor angiogenesis

68.

Which metabolic alteration is commonly observed in cancer cells?

a)

Increased oxidative phosphorylation

b)

Decreased glycolysis

c)

Aerobic glycolysis (Warburg effect)

d)

Increased fatty acid oxidation

69.

The BCL-2 gene plays a major role in:

a)

Tumor suppression

b)

Apoptosis inhibition

c)

DNA repair

d)

Cell cycle regulation

70.

The E-cadherin protein is important in:

a)

Promoting metastasis

b)

Cell-cell adhesion

c)

Stimulating angiogenesis

d)

Activating oncogenes

71.

Beta-2 microglobulin is a useful tumor marker for:

a)

Multiple myeloma

b)

Lung cancer

c)

Prostate cancer

d)

Breast cancer

72.

Which genetic abnormality is commonly found in acute promyelocytic leukemia (APL)?

a)

BCR-ABL translocation

b)

PML-RARA fusion gene

c)

MYC amplification

d)

TP53 mutation

73.

HER2/neu overexpression is commonly associated with:

a)

Prostate cancer

b)

Breast cancer

c)

Colon cancer

d)

Ovarian cancer

74.

CD20 is a marker commonly found in:

a)

T-cell lymphoma

b)

B-cell lymphomas

c)

Multiple myeloma

d)

Melanoma

75.

LDH (Lactate dehydrogenase) is used as a tumor marker for:

a)

Testicular cancer

b)

Ovarian cancer

c)

Lymphomas and leukemias

d)

Colon cancer

76.

ALP (Alkaline Phosphatase) elevation may indicate:

a)

Liver metastases and bone disease

b)

Breast cancer

c)

Gastric carcinoma

d)

Lung cancer

77.

S-100 protein is a tumor marker associated with:

a)

Leukemia

b)

Melanoma

c)

Lung cancer

d)

Breast cancer

78.

hCG (human chorionic gonadotropin) is elevated in:

a)

Testicular cancer and trophoblastic tumors

b)

Liver cancer

c)

Lung cancer

d)

Pancreatic cancer

79.

Neuroendocrine tumors can be detected using which marker?

a)

Chromogranin A

b)

AFP

c)

CA-19-9

d)

PSA

80.

N-MYC amplification is commonly seen in:

a)

Neuroblastoma

b)

Colorectal cancer

c)

Breast cancer

d)

Thyroid carcinoma

81.

Which of the following is a feature of oncogenes?

a)

They suppress tumor growth

b)

They encode proteins that promote cell division

c)

They repair DNA damage

d)

They induce apoptosis

82.

Which of the following genes is a proto-oncogene?

a)

TP53

b)

RB1

c)

KRAS

d)

BRCA2

83.

Li-Fraumeni syndrome is caused by mutations in:

a)

RB1

b)

TP53

c)

APC

d)

BRCA1

84.

Which of the following mechanisms allows cancer cells to evade immune surveillance?

a)

Upregulation of MHC class I

b)

Increased apoptosis

c)

Expression of PD-L1

d)

Increased antigen presentation

85.

The Warburg effect in cancer cells is characterized by:

a)

Increased oxidative phosphorylation

b)

Increased glycolysis even in the presence of oxygen

c)

Decreased glucose uptake

d)

Increased fatty acid oxidation

86.

The BCR-ABL fusion gene results from a translocation between:

a)

Chromosomes 9 and 22

b)

Chromosomes 8 and 14

c)

Chromosomes 11 and 22

d)

Chromosomes 17 and 22

87.

Which of the following cancers is associated with Helicobacter pylori infection?

a)

Colon cancer

b)

Gastric cancer

c)

Pancreatic cancer

d)

Esophageal cancer

88.

APC gene mutations are associated with which hereditary cancer syndrome?

a)

Hereditary breast cancer

b)

Lynch syndrome

c)

Familial adenomatous polyposis (FAP)

d)

Retinoblastoma

89.

Epithelial-to-mesenchymal transition (EMT) plays a key role in:

a)

Apoptosis

b)

Tumor invasion and metastasis

c)

DNA repair

d)

Angiogenesis

90.

Which type of DNA repair defect is responsible for xeroderma pigmentosum?

a)

Nucleotide excision repair defect

b)

Mismatch repair defect

c)

Homologous recombination defect

d)

Base excision repair defect

91.

CA-19-9 is most commonly elevated in:

a)

Prostate cancer

b)

Pancreatic cancer

c)

Testicular cancer

d)

Lung cancer

92.

Which tumor marker is primarily used for prostate cancer?

a)

AFP

b)

PSA

c)

CEA

d)

β-hCG

93.

Elevated AFP levels are seen in:

a)

Ovarian cancer

b)

Prostate cancer

c)

Hepatocellular carcinoma

d)

Lung cancer

94.

Chromogranin A is a marker for:

a)

Neuroendocrine tumors

b)

Leukemia

c)

Breast cancer

d)

Sarcomas

95.

S-100 protein is a diagnostic marker for:

a)

Colon cancer

b)

Melanoma

c)

Breast cancer

d)

Ovarian cancer

96.

Elevated CEA levels are commonly associated with:

a)

Breast cancer

b)

Colorectal cancer

c)

Brain tumors

d)

Leukemia

97.

BRCA1 and BRCA2 mutations are associated with:

a)

Stomach cancer

b)

Breast and ovarian cancer

c)

Prostate cancer

d)

Liver cancer

98.

hCG is elevated in which of the following conditions?

a)

Breast cancer

b)

Testicular cancer

c)

Colon cancer

d)

Leukemia

99.

Which tumor marker is most commonly associated with ovarian cancer?

a)

PSA

b)

CA-125

c)

LDH

d)

CA-19-9

100.

Which genetic mutation is associated with retinoblastoma?

a)

TP53

b)

RB1

c)

BRCA2

d)

KRAS