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WorksheetsCancer MCQs
Total questions: 100
Worksheet time: 50mins
What is the hallmark of cancer cells?
Limited proliferation
Apoptosis resistance
Increased differentiation
Decreased angiogenesis
Which of the following is a tumor suppressor gene?
RAS
MYC
TP53
HER2
The Warburg effect in cancer cells refers to:
Increased oxygen consumption
Reduced glycolysis
Enhanced aerobic glycolysis
Mitochondrial hyperactivity
Which process allows cancer cells to spread from the primary tumor to distant sites?
Apoptosis
Metastasis
Autophagy
Differentiation
Which tumor marker is primarily used for prostate cancer screening?
CEA
AFP
PSA
CA-125
Elevated levels of Alpha-fetoprotein (AFP) are associated with:
Breast cancer
Liver cancer
Colon cancer
Lung cancer
CA-125 is a marker primarily used for detecting:
Ovarian cancer
Pancreatic cancer
Gastric cancer
Skin cancer
HER2 overexpression is commonly seen in:
Lung cancer
Breast cancer
Prostate cancer
Thyroid cancer
Immunohistochemistry (IHC) is primarily used to:
Detect circulating tumor cells
Identify specific proteins in tissues
Analyze DNA mutations
Measure serum tumor markers
The Philadelphia chromosome is associated with which cancer?
Chronic myeloid leukemia (CML)
Breast cancer
Lung cancer
Melanoma
Which of the following is a characteristic of benign tumors?
Invasive growth
Well-differentiated cells
High metastatic potential
Rapid, uncontrolled division
Oncogenes are genes that:
Suppress tumor formation
Promote uncontrolled cell growth
Repair damaged DNA
Induce apoptosis
Which of the following pathways is commonly activated in cancer cells?
Wnt/β-catenin
Insulin signaling
G-protein coupled receptor signaling
TCA cycle
Loss of function in which of the following genes leads to defective DNA repair mechanisms?
BRCA1
MYC
KRAS
VEGF
Tumor angiogenesis is stimulated by:
TNF-alpha
VEGF
E-cadherin
Caspase-3
CEA (Carcinoembryonic Antigen) is a tumor marker primarily used for:
Breast cancer
Colorectal cancer
Pancreatic cancer
Ovarian cancer
A high level of hCG (human chorionic gonadotropin) is associated with:
Testicular and trophoblastic tumors
Lung cancer
Thyroid cancer
Pancreatic cancer
Which tumor marker is commonly used in pancreatic cancer?
CA-19-9
CEA
PSA
CA-125
Which molecular marker is used for targeted therapy in lung cancer?
EGFR
HER2
BRCA1
CA-125
A mutation in the BRAF gene is commonly associated with:
Colorectal cancer
Melanoma
Prostate cancer
Ovarian cancer
Which of the following is NOT a hallmark of cancer?
Sustained angiogenesis
Evasion of apoptosis
Decreased cell proliferation
Ability to metastasize
Which of the following is an anti-apoptotic protein that promotes cancer cell survival?
Bax
Bcl-2
Caspase-3
P53
Which enzyme is responsible for maintaining telomere length in cancer cells?
DNA polymerase
Telomerase
Ligase
Topoisomerase
Which type of gene is involved in preventing uncontrolled cell growth?
Oncogenes
Tumor suppressor genes
Proto-oncogenes
Homeotic genes
Which protein is known as the "guardian of the genome"?
Rb
p53
Cyclin D
Akt
Loss of function of which gene leads to hereditary breast cancer?
BRCA1
HER2
KRAS
TP53
The epithelial-to-mesenchymal transition (EMT) in cancer is primarily associated with:
Angiogenesis
Metastasis
Tumor initiation
DNA repair
Inherited mutations in the APC gene are associated with which type of cancer?
Breast cancer
Colorectal cancer
Lung cancer
Pancreatic cancer
Which tumor marker is most commonly used to monitor hepatocellular carcinoma?
CEA
AFP
CA-19-9
PSA
Which molecular marker is targeted by the drug trastuzumab (Herceptin)?
EGFR
HER2
BRCA1
KRAS
Mutations in which gene are commonly found in pancreatic cancer?
BRCA2
KRAS
EGFR
TP53
Which of the following tumor markers is used for medullary thyroid carcinoma?
Thyroglobulin
CEA
Calcitonin
CA-125
Elevated CA-19-9 levels are most often associated with:
Gastric cancer
Pancreatic cancer
Breast cancer
Ovarian cancer
Lynch syndrome is associated with mutations in:
Mismatch repair genes
BRCA1
RAS
MYC
A mutation in the VHL gene is associated with:
Retinoblastoma
Von Hippel-Lindau syndrome
Multiple myeloma
Colorectal cancer
Which of the following tumor markers is used to detect choriocarcinoma?
AFP
β-hCG
CA-125
CEA
The presence of BCR-ABL fusion protein is a hallmark of:
Acute lymphoblastic leukemia (ALL)
Chronic myeloid leukemia (CML)
Lung cancer
Breast cancer
Which of the following is a major risk factor for hepatocellular carcinoma?
HPV infection
Hepatitis B and C infection
Smoking
Helicobacter pylori infection
The presence of microsatellite instability (MSI) is a hallmark of:
Lynch syndrome
Retinoblastoma
Small cell lung cancer
Gastric adenocarcinoma
A mutation in the NF1 gene is associated with:
Neurofibromatosis type 1
Melanoma
Colon cancer
Lung cancer
Which of the following is a key feature of cancer cells?
Contact inhibition
Uncontrolled proliferation
Shortened lifespan
Decreased telomerase activity
The two-hit hypothesis is associated with which tumor suppressor gene?
p53
BRCA1
RB1
APC
Which gene mutation is most frequently associated with human cancers?
MYC
KRAS
TP53
EGFR
Which type of cancer is most commonly caused by HPV infection?
Liver cancer
Cervical cancer
Lung cancer
Pancreatic cancer
Tumor cells that undergo epithelial-to-mesenchymal transition (EMT) show:
Reduced motility
Decreased metastatic potential
Loss of cell-cell adhesion
Increased differentiation
Which of the following is NOT a tumor suppressor gene?
RB1
p53
KRAS
APC
The activation of which enzyme allows cancer cells to maintain telomere length?
Telomerase
DNA ligase
Caspase-9
Reverse transcriptase
The Knudson Hypothesis explains the development of:
Lung cancer
Retinoblastoma
Prostate cancer
Leukemia
Mutations in mismatch repair (MMR) genes lead to:
Hereditary non-polyposis colorectal cancer (HNPCC)
Breast cancer
Lung cancer
Melanoma
Which of the following viruses is associated with Burkitt’s lymphoma?
HPV
Epstein-Barr virus (EBV)
Hepatitis B virus (HBV)
Human immunodeficiency virus (HIV)
Which tumor marker is commonly used for testicular cancer?
PSA
β-hCG
CA-19-9
CEA
BRCA1 and BRCA2 mutations are associated with an increased risk of:
Lung cancer
Breast and ovarian cancer
Colorectal cancer
Liver cancer
The presence of Philadelphia chromosome (t[9;22]) is associated with:
Hodgkin’s lymphoma
Chronic myeloid leukemia (CML)
Lung cancer
Multiple myeloma
A tumor marker used for monitoring colorectal cancer is:
CA-125
CEA
AFP
β-hCG
Which tumor marker is used to diagnose hepatocellular carcinoma?
CA-19-9
AFP
PSA
LDH
Which cancer is associated with an elevated calcitonin level?
Prostate cancer
Medullary thyroid carcinoma
Pancreatic cancer
Ovarian cancer
Elevated serum CA-125 is most indicative of:
Liver cancer
Ovarian cancer
Colon cancer
Prostate cancer
Which of the following markers is commonly used in the diagnosis of multiple myeloma?
Beta-2 microglobulin
PSA
HER2
AFP
A mutation in the RET proto-oncogene is associated with:
Medullary thyroid carcinoma
Breast cancer
Colorectal cancer
Pancreatic cancer
Which genetic mutation is associated with melanoma?
BRAF V600E
ALK rearrangement
APC mutation
JAK2 mutation
Which of the following is a common characteristic of malignant tumors?
Encapsulation
Slow growth
Invasion and metastasis
Well-differentiated cells
Which oncogene is most frequently mutated in human cancers?
MYC
KRAS
HER2
TP53
Angiogenesis in tumors is primarily driven by:
E-cadherin
Caspase-9
VEGF
Cyclin D
The mutator phenotype hypothesis suggests that cancer arises due to:
Increased apoptosis
Loss of DNA repair mechanisms
Suppression of oncogenes
Overexpression of tumor suppressor genes
The main function of RB1 in normal cells is to:
Promote cell cycle progression
Prevent excessive cell division
Induce apoptosis
Activate oncogenes
Which of the following viruses is linked to hepatocellular carcinoma?
HPV
Hepatitis B and C viruses
Epstein-Barr virus
HIV
The P53 tumor suppressor gene regulates:
DNA replication
Cell cycle arrest and apoptosis
Protein synthesis
Tumor angiogenesis
Which metabolic alteration is commonly observed in cancer cells?
Increased oxidative phosphorylation
Decreased glycolysis
Aerobic glycolysis (Warburg effect)
Increased fatty acid oxidation
The BCL-2 gene plays a major role in:
Tumor suppression
Apoptosis inhibition
DNA repair
Cell cycle regulation
The E-cadherin protein is important in:
Promoting metastasis
Cell-cell adhesion
Stimulating angiogenesis
Activating oncogenes
Beta-2 microglobulin is a useful tumor marker for:
Multiple myeloma
Lung cancer
Prostate cancer
Breast cancer
Which genetic abnormality is commonly found in acute promyelocytic leukemia (APL)?
BCR-ABL translocation
PML-RARA fusion gene
MYC amplification
TP53 mutation
HER2/neu overexpression is commonly associated with:
Prostate cancer
Breast cancer
Colon cancer
Ovarian cancer
CD20 is a marker commonly found in:
T-cell lymphoma
B-cell lymphomas
Multiple myeloma
Melanoma
LDH (Lactate dehydrogenase) is used as a tumor marker for:
Testicular cancer
Ovarian cancer
Lymphomas and leukemias
Colon cancer
ALP (Alkaline Phosphatase) elevation may indicate:
Liver metastases and bone disease
Breast cancer
Gastric carcinoma
Lung cancer
S-100 protein is a tumor marker associated with:
Leukemia
Melanoma
Lung cancer
Breast cancer
hCG (human chorionic gonadotropin) is elevated in:
Testicular cancer and trophoblastic tumors
Liver cancer
Lung cancer
Pancreatic cancer
Neuroendocrine tumors can be detected using which marker?
Chromogranin A
AFP
CA-19-9
PSA
N-MYC amplification is commonly seen in:
Neuroblastoma
Colorectal cancer
Breast cancer
Thyroid carcinoma
Which of the following is a feature of oncogenes?
They suppress tumor growth
They encode proteins that promote cell division
They repair DNA damage
They induce apoptosis
Which of the following genes is a proto-oncogene?
TP53
RB1
KRAS
BRCA2
Li-Fraumeni syndrome is caused by mutations in:
RB1
TP53
APC
BRCA1
Which of the following mechanisms allows cancer cells to evade immune surveillance?
Upregulation of MHC class I
Increased apoptosis
Expression of PD-L1
Increased antigen presentation
The Warburg effect in cancer cells is characterized by:
Increased oxidative phosphorylation
Increased glycolysis even in the presence of oxygen
Decreased glucose uptake
Increased fatty acid oxidation
The BCR-ABL fusion gene results from a translocation between:
Chromosomes 9 and 22
Chromosomes 8 and 14
Chromosomes 11 and 22
Chromosomes 17 and 22
Which of the following cancers is associated with Helicobacter pylori infection?
Colon cancer
Gastric cancer
Pancreatic cancer
Esophageal cancer
APC gene mutations are associated with which hereditary cancer syndrome?
Hereditary breast cancer
Lynch syndrome
Familial adenomatous polyposis (FAP)
Retinoblastoma
Epithelial-to-mesenchymal transition (EMT) plays a key role in:
Apoptosis
Tumor invasion and metastasis
DNA repair
Angiogenesis
Which type of DNA repair defect is responsible for xeroderma pigmentosum?
Nucleotide excision repair defect
Mismatch repair defect
Homologous recombination defect
Base excision repair defect
CA-19-9 is most commonly elevated in:
Prostate cancer
Pancreatic cancer
Testicular cancer
Lung cancer
Which tumor marker is primarily used for prostate cancer?
AFP
PSA
CEA
β-hCG
Elevated AFP levels are seen in:
Ovarian cancer
Prostate cancer
Hepatocellular carcinoma
Lung cancer
Chromogranin A is a marker for:
Neuroendocrine tumors
Leukemia
Breast cancer
Sarcomas
S-100 protein is a diagnostic marker for:
Colon cancer
Melanoma
Breast cancer
Ovarian cancer
Elevated CEA levels are commonly associated with:
Breast cancer
Colorectal cancer
Brain tumors
Leukemia
BRCA1 and BRCA2 mutations are associated with:
Stomach cancer
Breast and ovarian cancer
Prostate cancer
Liver cancer
hCG is elevated in which of the following conditions?
Breast cancer
Testicular cancer
Colon cancer
Leukemia
Which tumor marker is most commonly associated with ovarian cancer?
PSA
CA-125
LDH
CA-19-9
Which genetic mutation is associated with retinoblastoma?
TP53
RB1
BRCA2
KRAS
