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PODA III EXAM 4 FALL 2025

Total questions: 35

Worksheet time: 18mins

Name
Class
Date
1.

Which of the following is BEST classified as a mold?

a)

Candida auris

b)

Rhizomucor pussilus

c)

Torulopsis glabrata

d)

Cryptococcus neoformans

e)

Trichosporon beigelii

2.

Which of the following is a Methotrexate analog that is MOST LIKELY to be employed in the treatment of Liver cancer?

a)

Phototrexate

b)

Pemetrexed

c)

Pralatrexate

d)

Nolatrexed (Thymitaq)

e)

Edatrexate

3.

Which of the following produces its antifungal effect by inhibiting Leucyl-tRNA synthetase in the cytoplasm?

a)

Omoconazole

b)

Haloprogin

c)

Ciclopirox (Penlac)

d)

Griseofulvin (Fulvicin)

e)

Tavaborole (Kerydin)

4.

All of the following are inhibitors of fungal cell wall synthesis EXCEPT:

a)

Aculeacins

b)

Pneumocandins

c)

Nikkomycins

d)

Undecylenic acid

e)

Polyoxin-D

5.

Which of the following is a triazole antifungal drug that is used primarily for the management of onychomycosis?

a)

Miconazole

b)

Terconazole

c)

Efinaconazole

d)

Econazole

e)

Sertaconazole

6.

Which of the following is an imidazole antifungal drug that is used primarily for the management of vaginal candidiasis?

a)

Butoconazole

b)

Terconazole

c)

Voriconazole

d)

Luliconazole

e)

Sulconazole

7.

Methotrexate has been found to be useful in which of the following conditions?

a)

Procuring an abortion

b)

Rheumatoid arthritis

c)

PCP

d)

Cutaneous T-cell lymphoma

e)

Psoriasis

8.

Which of the following is the CORRECT maintenance dose of Rezzayo for the treatment of invasive candidiasis?

a)

400mg PO QD

b)

200mg PO BID

c)

200mg IV weekly

d)

200mg IV QD

e)

400mg IV twice a week

9.

Mr. Zut, who has been diagnosed with a Chlamydia infection, presents with urethritis, arthritis and conjunctivitis. Which of the following is MOST LIKELY to be used in managing his current presentation?

a)

Ancobon

b)

Adrcuil

c)

Mexate

d)

Cytoxan

e)

Platinol

10.

All of the following statements about Cyclophosphamide are true EXCEPT: The drug is:

a)

An Alkylating agent

b)

An immunosuppressive agent

c)

An antiemetic agent

d)

An anti-inflammatory agent

e)

A teratogenic agent

11.

Pulmonary fibrosis is the TLT for which of the following?

a)

Adriamycin

b)

Bleomycin

c)

Cisplatin

d)

Dactinomycin

e)

Etoposide

12.

Which of the following is employed in the prevention or the management of the TLT of Cytoxan?

a)

Soliris

b)

Hydration

c)

Ifosfamide

d)

Mesna

e)

Mucomyst

13.

For the treatment of Multiple myeloma, Dexamethasone is combined with which of the following? (SELECT ALL THAT APPLY):

a)

Velcade

b)

Kyprolis

c)

Darzalex

d)

Oncovin and Adriamycin

e)

Empliciti

14.

Which of the following is NOT contained in the M2 regimen that is used to treat Multiple myeloma?

a)

CCNU

b)

Cytoxan

c)

Melphalan

d)

Carmustine

e)

Vincristine

15.

Which of the following is an indication of 5-Fluorouracil?

a)

Superficial basal cell carcinoma

b)

Myasthenia gravis

c)

Condylomata acuminata

d)

Pancreatic cancer

e)

Acute cerebellar syndrome

16.

Which of the following is an indication of 5-Fluorocytosine?

a)

Chromoblastomycosis

b)

Sporotrichosis

c)

Coccidioidomycosis

d)

Cryptococcal meningitis

e)

Candida-induced septicemia

17.

Which of the following statements about Ibrexafungerp is FALSE?

a)

It is a substrate for CYP 3A4

b)

It inhibits CYP 2C8

c)

It is highly plasma protein bound

d)

It primarily undergoes renal excretion

e)

It has a half-life of about 20 hours

18.

Which of the following statements about Brexafemme is FALSE?

a)

It is a triterpenoid antifungal agent

b)

It is an inhibitor of cell membrane synthesis

c)

It is employed in treating a Candida infection that is resistant to Ecchinocandins and Triazole antifungals

d)

It is employed in the treatment of vulvovaginal candidiasis

e)

It is administered on a BID basis

19.

Which of the following is involved in the mechanism of action of Methotrexate in neoplasms? (SELECT ALL THAT APPLY)

a)

Alkylation of nucleic acids

b)

Inhibition of Thymidylate synthase

c)

Inhibition of de novo synthesis of nucleic acids

d)

Inhibition of Dihydrofolate reductase

e)

Inhibition of Aldehyde oxidase

20.

Which of the following is absent from the Hyper-CVAD A regimen when it is employed in managing Acute Lymphocytic Leukemia?

a)

Adriamycin

b)

Cytarabine

c)

Cyclophosphamide

d)

Dactinomycin

e)

Dexamethasone

21.

Which of the following statements about Hyper-CVAD B is FALSE?

a)

It is employed in managing Acute Lymphocytic Leukemia

b)

It contains Methotrexate

c)

It consists of ara-A

d)

It is given for 21 days in each cycle

e)

Its administration commences after giving the Hyper-CVAD A regimen for 21 days

22.

With concurrent administration, Fluconazole will elevate the AUC of which of the following?

a)

Antidepressants

b)

Antiepileptics

c)

Plavix

d)

Proton Pump Inhibitors

e)

Oral Hypoglycemics

23.

Which of the following statements about Terbinafine is INCORRECT?

a)

It decreases the metabolism of SSRIs

b)

It accentuates the hepatotoxicity of Alcohol

c)

It decreases the duration of action of Caffeine

d)

It decreases the metabolism of Tricyclic antidepressants

e)

Its absorption is impaired by acidic food

24.

Which of the following statements about Amphotericin B is FALSE? (SELECT ALL THAT APPLY)

a)

Its Lipid Complex formulation consists of a 7:3 ratio of Dimyristoylphosphatidyl glycerol to Dimyristoylphosphatidyl choline

b)

Its deoxycholate preparation can be administered with Intralipid

c)

It can be administered intravitreally, subconjunctivally and intra-articularly

d)

It is well distributed into the pleural, peritoneal and synovial compartments

e)

Its terminal half-life is 15 hours

25.

Itraconazole is effective in the treatment of which of the following conditions? (SELECT ALL THAT APPLY)

a)

Pseudallescheriasis

b)

Protothecosis

c)

Leishmaniasis

d)

Sporotrichosis

e)

Amoebic meningoencephalitis caused by Naegleria fowleri

26.

Which of the following statements about Vfend is FALSE?

a)

It is a strong inhibitor of CYP 3A4

b)

It is a substrate for CYP 2C9 and 2C19

c)

Its initial dosing regimen, when given IV for Aspergillosis treatment, is 6mg/kg Q 12hr X 2 doses

d)

It can impair night vision and also cause chromatopsia

e)

It is effective against the sexual form of Pseudallescheria boydii

27.

Which of the following is consistent with a long-term adverse effect of Amphotericin B?

a)

A serum creatinine of 2.0 mg/dL

b)

Hypomagnesemia, Hypokalemia, Hypercalcemia

c)

Hemoptysis, Epistaxis, Melena

d)

A BUN of 27mg/dL

e)

Bradycardia and Normocytic, normochromic anemia

28.

Which of the following is NOT present in the EMA-CO combination anticancer regimen?

a)

Vincristine

b)

Adriamycin

c)

Methotrexate

d)

Etoposide

e)

Cyclophosphamide

29.

Select the INCORRECT statement about the EP-EMA combination anticancer regimen: (SELECT ALL THAT APPLY)

a)

It consists of a Topoisomerase inhibitor

b)

It is used to treat Hydatidiform mole

c)

It is used to treat Choriocarcinoma

d)

It consists of an Anthracycline antibiotic

e)

It consists of a Taxane

30.

Which of the following is LEAST LIKELY to be an indication of Edatrexate?

a)

Breast cancer

b)

Head and Neck cancer

c)

Non-Hodgkin’s lymphoma

d)

Non-Small Cell Lung Cancer

e)

Pancreatic cancer

31.

Which of the following combination anticancer regimens is NOT matched with the correct type of cancer that it is used to treat?

a)

CYVADIC Osteosarcoma

b)

OFF Pancreatic cancer

c)

MBC Colorectal cancer

d)

ELF Stomach cancer

e)

MACOA Burkitt’s lymphoma

32.

Which of the following combination anticancer regimens that are employed in managing Breast cancer consists of an Anabolic steroid and an Ethylenimine Alkylating agent?

a)

FECD

b)

VATH

c)

TCHP

d)

ACTH

e)

IMF

33.

Since Ms. Rul is severely allergic to Cisplatin, which of the following should be employed in treating her Ovarian cancer?

a)

CHAD

b)

Olaparib

c)

Irinotecan

d)

CISCA

e)

CAP

34.

Which of the following combination regimens that are being used to treat Mrs. Luq’s breast cancer accurately suggests that Mrs. Luq is receiving two Human Epidermal Growth Factor Receptor inhibitors?

a)

NFL

b)

TCP

c)

TDP

d)

ACD

e)

ACTH

35.

Which of the following is used to treat Colorectal cancer? (SELECT ALL THAT APPLY)

a)

CAPOX

b)

FOLFIRI + Cetuximab

c)

XELOX

d)

Dostarlumab

e)

CMV

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